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Admin - October 12, 2020


Allicin | Organosulfur Compound And Defensive Molecule | Biofron

Allicin is an organosulfur compound and a defensive molecule obtained from garlic when it is crushed, chewed or chopped, an enzyme called allinase, is released from garlic and it interacts with alliin to form allicin. This compound has several health related benefits and allicin is the main biologically active compound of garlic. Allicin is an oily liquid in yellow color giving garlic a exclusive odor.

Chemical Structural Formula of Allicin

CAS no: 539-86-6

  • Molecular formula: C6H10OS2
  • Molar mass: 162.28 g/mol
  • Density: 1.11 g/cm3
  • Melting point: ˂ 25 °C
  • Boiling point: 248.6 °C
  • Synonym
    539-86-6 Diallyl thiosulfinate . Diallyldisulfid-S-oxidSTRUCTURAL COMPOSITION
    Garlic is when crushed or chopped releases an enzyme allinase which plays a catalytic role in formation of allicin from S-allyl-L-cysteine sulfoxide (allin). This further break down to form allicin and other organosulfur compounds. Biosynthesis of allicin commences with the exchange of cysteine into S-allyl-L-cysteine, and its oxidation gives the sulfoxide (Allin). The enzyme allinase containing pyridoxal phosphate, cleaves allin, producing allylsulfenic acid (CH2=CHCH2SOH), pyruvate, and ammonium ions. Then two molecule of allylsulfenic acid condense to form allicin at room temperature.
    Garlic was being used thousands years ago to gain its health benefits and modern medical research proved the health beneficial properties of garlic. Garlic derived compound mainly allicin was discovered and showed its properties to fight against different disease such as cardiovascular disease, to lower blood pressure, cholesterol, and fatty acid in the blood. Its anti tumor properties established, providing for a potential use in cancer therapy. Moreover its antimicrobial activity pragmatic in raw garlic forms. In addition bacteria, its more capturing effects have been analyzed against different viruses, fungi and protozoa. Distinct other conventional antibiotics, allicin found more impulsive and can destroy bacteria via the gas phase.
    Allicin supplements are very efficient for boosting the immune system functionality. A study was carried out in order to check its efficiency the symptom of cold and flu were reduced to 70% in few days.
    The world’s deadly diseases are cardiovascular disease and heart stroke. These diseases take place due to the factor of hypertension or high blood pressure. A research on allicin supplements was taken and resultantly it found to have a significant impact on lowering blood pressure. Moreover allicin is helpful for reducing the LDL cholesterol levels. A study found that high cholesterol patient can lower his cholesterol level by 15-20% by taking garlic’s supplements. Another cause of heart disease is high triglyceride but allicin was not found that much efficient for lowering the high triglyceride levels.

    ■ According to many researches, allicin has been found to be an effective compound for lowering cholesterol levels.
    ■ It is proved by research that allicin may help regulate blood pressure and is more effective than any medicine for treatment of hypertension.
    ■ Garlic or allicin have excellent anti oxidant properties that protects aging process caused due to oxidative damage from free radicals. Antioxidants in allicin are very supportive to the body’s protective mechanism against oxidative damage.
    ■ The multiple effects of allicin on reducing the blood pressure and LDL cholesterol along with its antioxidant properties may reduce the risk of brain diseases such as Alzheimer’s disease and dementia.
    ■ It is helpful for reducing inflammation due to its antioxidant properties.
    ■ Garlic is known to be a performance enhancer for people related to sports. Even it was anciently used to reduce stress/fatigue and to enhance the working capacity of labors. In earliest time it was given to Olympic athletes in Greece.
    ■ The patients of cardiovascular disease who took allicin oil for 4 to 6 weeks had 12% reduction in their peak heart rate and enhanced exercise capacity.
    Hence Allicin has many therapeutic properties.

    Below are the following highlights of its benefits.
    Antioxidant, performance enhancer, lower cholesterol levels, lower blood pressure, fight cardiovascular disease and cancer, enhance stamina, anti-inflammatory.

    Allicin may also increase the risk of bleeding, if you are taking medicine of thinning blood then avoid this medicine before going to surgery.
    Allicin supplements may have possible side effects of diarrhea, gas, heart burn and nausea.
    Allicin medicine should not be taken along with other hypertension medicine; it may lower the blood pressure.
    It should be not be taken along with anti diabetic drug, as it can lower blood sugar levels.