Catalogue Number
BD-D1247
Analysis Method
HPLC,NMR,MS
Specification
90%(HPLC)
Storage
-20℃
Molecular Weight
204.36
Appearance
Oil
Botanical Source
Structure Type
Sesquiterpenoids
Category
SMILES
CC1=CCCC(=C)C2CC(C2CC1)(C)C
Synonyms
IUPAC Name
Density
0.9±0.1 g/cm3
Solubility
Ethanol : ≥ 176.67 mg/mL (864.55 mM)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 0.1 mg/mL (insoluble)
*"≥" means soluble, but saturation unknown.
Flash Point
104.9±13.8 °C
Boiling Point
268.4±10.0 °C at 760 mmHg
Melting Point
InChl
InChI=1S/C15H24/c1-11-6-5-7-12(2)13-10-15(3,4)14(13)9-8-11/h6,13-14H,2,5,7-10H2,1,3-4H3/b11-6+/t13-,14-/m1/s1
InChl Key
NPNUFJAVOOONJE-GFUGXAQUSA-N
WGK Germany
RID/ADR
HS Code Reference
2902190000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:87-44-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
32343912
Response to Chen et al. re: " β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice"
P Chavez-Hurtado 1, R E Gonzalez-CastaNeda 2, C Beas-Zarate 3, M E Flores-Soto 4, J M Viveros-Paredes 1
2020 Jun;
32176567
Re: " β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice" by Chavez-Hurtado et al
Peng Chen 1, Jiexin Lei 2, Benhong Zhou 1
2020 Jun;
31892132
Neuropathic pain associated with nucleoside reverse transcriptase inhibitors (NRTIs), therapeutic agents for human immunodeficiency virus (HIV), responds poorly to available drugs. Smoked cannabis was reported to relieve HIV-associated neuropathic pain in clinical trials. Some constituents of cannabis (Cannabis sativa) activate cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors. However, activation of the CB1 receptor is associated with side effects such as psychosis and physical dependence. Therefore, we investigated the effect of β-caryophyllene (BCP), a CB2-selective phytocannabinoid, in a model of NRTI-induced neuropathic pain. Female BALB/c mice treated with 2′-3′-dideoxycytidine (ddC, zalcitabine), a NRTI, for 5 days developed mechanical allodynia, which was prevented by cotreatment with BCP, minocycline or pentoxifylline. A CB2 receptor antagonist (AM 630), but not a CB1 receptor antagonist (AM 251), antagonized BCP attenuation of established ddC-induced mechanical allodynia. β-Caryophyllene prevented the ddC-induced increase in cytokine (interleukin 1 beta, tumor necrosis factor alpha and interferon gamma) transcripts in the paw skin and brain, as well as the phosphorylation level of Erk1/2 in the brain. In conclusion, BCP prevents NRTI-induced mechanical allodynia, possibly via reducing the inflammatory response, and attenuates mechanical allodynia through CB2 receptor activation. Therefore, BCP could be useful for prevention and treatment of antiretroviral-induced neuropathic pain.
CB2 receptor; antiretroviral; cytokines; ddC; mechanical allodynia; neuropathic pain; nucleoside reverse transcriptase inhibitor; phytocannabinoid; β-caryophyllene.
β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain
Esraa Aly 1, Maitham A Khajah 1, Willias Masocha 1
2019 Dec 27
