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β-Caryophyllene

$45

  • Brand : BIOFRON

  • Catalogue Number : AV-P11176

  • Specification : 90%

  • CAS number : 87-44-5

  • Formula : C15H24

  • Molecular Weight : 204.36

  • Volume : 0.5ml

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Catalogue Number

AV-P11176

Analysis Method

HPLC,NMR,MS

Specification

90%

Storage

-20℃

Molecular Weight

204.36

Appearance

Oil

Botanical Source

Structure Type

Sesquiterpenoids

Category

SMILES

CC1=CCCC(=C)C2CC(C2CC1)(C)C

Synonyms

IUPAC Name

Applications

Density

0.9±0.1 g/cm3

Solubility

Ethanol : ≥ 176.67 mg/mL (864.55 mM)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 0.1 mg/mL (insoluble)
*"≥" means soluble, but saturation unknown.

Flash Point

104.9±13.8 °C

Boiling Point

268.4±10.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C15H24/c1-11-6-5-7-12(2)13-10-15(3,4)14(13)9-8-11/h6,13-14H,2,5,7-10H2,1,3-4H3/b11-6+/t13-,14-/m1/s1

InChl Key

NPNUFJAVOOONJE-GFUGXAQUSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:87-44-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32343912

Title

Response to Chen et al. re: " β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice"

Author

P Chavez-Hurtado 1, R E Gonzalez-CastaNeda 2, C Beas-Zarate 3, M E Flores-Soto 4, J M Viveros-Paredes 1

Publish date

2020 Jun;

PMID

32176567

Title

Re: " β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice" by Chavez-Hurtado et al

Author

Peng Chen 1, Jiexin Lei 2, Benhong Zhou 1

Publish date

2020 Jun;

PMID

31892132

Abstract

Neuropathic pain associated with nucleoside reverse transcriptase inhibitors (NRTIs), therapeutic agents for human immunodeficiency virus (HIV), responds poorly to available drugs. Smoked cannabis was reported to relieve HIV-associated neuropathic pain in clinical trials. Some constituents of cannabis (Cannabis sativa) activate cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2) receptors. However, activation of the CB1 receptor is associated with side effects such as psychosis and physical dependence. Therefore, we investigated the effect of β-caryophyllene (BCP), a CB2-selective phytocannabinoid, in a model of NRTI-induced neuropathic pain. Female BALB/c mice treated with 2′-3′-dideoxycytidine (ddC, zalcitabine), a NRTI, for 5 days developed mechanical allodynia, which was prevented by cotreatment with BCP, minocycline or pentoxifylline. A CB2 receptor antagonist (AM 630), but not a CB1 receptor antagonist (AM 251), antagonized BCP attenuation of established ddC-induced mechanical allodynia. β-Caryophyllene prevented the ddC-induced increase in cytokine (interleukin 1 beta, tumor necrosis factor alpha and interferon gamma) transcripts in the paw skin and brain, as well as the phosphorylation level of Erk1/2 in the brain. In conclusion, BCP prevents NRTI-induced mechanical allodynia, possibly via reducing the inflammatory response, and attenuates mechanical allodynia through CB2 receptor activation. Therefore, BCP could be useful for prevention and treatment of antiretroviral-induced neuropathic pain.

KEYWORDS

CB2 receptor; antiretroviral; cytokines; ddC; mechanical allodynia; neuropathic pain; nucleoside reverse transcriptase inhibitor; phytocannabinoid; β-caryophyllene.

Title

β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain

Author

Esraa Aly 1, Maitham A Khajah 1, Willias Masocha 1

Publish date

2019 Dec 27