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γ-Asarone

$896

  • Brand : BIOFRON

  • Catalogue Number : BD-P0536

  • Specification : 90.0%(HPLC)

  • CAS number : 5353-15-1

  • Formula : C12H16O3

  • Molecular Weight : 208.25

  • PUBCHEM ID : 636750

  • Volume : 0.05ml

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Catalogue Number

BD-P0536

Analysis Method

HPLC,NMR,MS

Specification

90.0%(HPLC)

Storage

-20℃

Molecular Weight

208.25

Appearance

Botanical Source

Structure Type

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC(=C(C=C1CC=C)OC)OC

Synonyms

(2,4,5-trimethoxyphenyl)prop-1-ene/1,2,4-TRIMETHOXY-5-ALLYLBENZENE/Benzene,1,2,4-trimethoxy-5-(2-propenyl)/2,4,5-Trimethoxyallylbenzene/1-Allyl-2,4,5-trimethoxy-benzol/1-allyl-2,4,5-trimethoxybenzene

IUPAC Name

1,2,4-trimethoxy-5-prop-2-enylbenzene

Applications

Density

1.011g/cm3

Solubility

Flash Point

95.4ºC

Boiling Point

287.7ºC at 760 mmHg

Melting Point

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2909300000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:5353-15-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

18641286

Abstract

Purpose
There are distinctive areas of colocalization of matrix metalloproteinase (MMP)-2 and -14 on trabecular meshwork (TM) cells that resemble podosomes or invadopodia. Studies were conducted to determine whether TM cells exhibit podosome- or invadopodia-like structures (PILS) and whether they produce focal extracellular matrix (ECM) turnover.

Methods
Porcine and human TM cells and perfused anterior segment organ cultures were studied. Localization of PILS components on TM cells and in sections from anterior segments was determined by immunohistochemistry and confocal microscopy. Cells were grown on type I collagen labeled with fluorescein isothiocyanate (FITC) for degradation analysis. Confocal time lapse images were taken of labeled TM cells on FITC-collagen.

Results
Immunostaining for MMP-2, MMP-14, and the typical PILS components cortactin, caldesmon, α-actinin, N-WASP, Arp-3, and cdc42 colocalized on these distinctive structures. Integrin-αV and -β1, fibronectin, and versican colocalized with PILS components. TM cells on FITC-conjugated collagen developed focal regions of degradation. Time-lapse imaging showed dramatic and controlled movement of TM cell processes during this ECM degradation and fragment internalization. MMP-2, MMP-14, and cortactin colocalized at regions that appear to be PILS on cells within the outflow pathway in sections of human anterior segments.

Conclusions
TM cells exhibit areas where PILS components colocalize with MMP-2 and -14. Similar structures are found in sections, suggesting that PILS occur in situ in the outflow pathway. The collagen degradation suggests that PILS may serve as focal sites for targeted ECM turnover, an event linked to modifications of aqueous outflow resistance and intraocular pressure homeostasis.

Title

Specialized Podosome- or Invadopodia-like Structures (PILS) for Focal Trabecular Meshwork Extracellular Matrix Turnover

Author

Mini Aga, John M. Bradley, Kate E. Keller, Mary J. Kelley, and Ted S. Acott

Publish date

2009 Dec 1.

PMID

3601674

Abstract

Coupling efficiencies for the covalent attachment of oligonucleotides (17-29 bases in length) to solid supports derivatized with alkyl-amino and -carboxylic functionalities have been determined. Attachment efficiencies of 60-80% were obtained for coated long-chain alkylamino controlled pore glass (CPG) supports. Similar efficiencies of immobilization were observed for carboxyl-bearing supports, which additionally exhibited lower levels of non-covalent binding. The extent of terminally linked oligonucleotide was determined to be 50-55% of the overall attachment in the carbodiimide-mediated coupling reaction of a 5′-aminohexyl phosphoramidate derivative of a 29-mer to Sephacryl carboxyl support. While lower overall efficiencies of attachment were obtained in the reaction with Sephacryl N-hydroxysuccinimide-activated carboxyl support, greater than 80% of this coupling results in end-attached oligonucleotides.

Title

Covalent attachment of oligonucleotides to solid supports.

Author

S S Ghosh and G F Musso

Publish date

1987 Jul 10;

PMID

10739025

Abstract

Pancreata of fetal, neonatal and adult cattle were studied immunohistochemically for galanin. The results revealed galanin-like immunoreactivity both in the endocrine cells and in the neural elements. The galanin-like immunoreactive endocrine cells (Gal-LIEC) were confined to the large islets, and were not observed in the islets of Langerhans and exocrine pancreas. They were first detected at the third prenatal month. Their developmental profile showed an increase from fetal to early neonatal stage with a subsequent decrease towards adulthood. The considerable number of Gal-LIEC from late prepartum to early postpartum stage may imply functional significance of galanin during the perinatal development of cattle. Coexistence of galanin and insulin was also observed which may suggest autocrine interaction between the 2 hormones.

KEYWORDS

Immunohistochemistry, insulin, large islets, cattle

Title

Galanin-like immunoreactive endocrine cells in bovine pancreas

Author

EMMANUEL T. BALTAZAR,1 NOBUO KITAMURA,1 EIICHI HONDO,1 ERLINDA C. NARRETO,2 and JUNZO YAMADA1

Publish date

2000 Feb;