3,5-dimethyl-1-prop-2-enylpyrazole/1-ALLYL-3,5-DIMETHYLPYRAZOLE/1-ALLYL-3 5-DIMETHYLPYRAZOLE 96
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provides coniferyl ferulate(CAS#:13369-74-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Hepatocytes are functionally heterogeneous and are divided into two distinct populations based on their metabolic zonation: the periportal and pericentral hepatocytes. During liver injury and regeneration, the cellular dynamics of these two distinct populations remain largely elusive. Here we show that major facilitator super family domain containing 2a (Mfsd2a), previously known to maintain blood-brain barrier function, is a periportal zonation marker. By genetic lineage tracing of Mfsd2a+ periportal hepatocytes, we show that Mfsd2a+ population decreases during liver homeostasis. Nevertheless, liver regeneration induced by partial hepatectomy significantly stimulates expansion of the Mfsd2a+ periportal hepatocytes. Similarly, during chronic liver injury, the Mfsd2a+ hepatocyte population expands and completely replaces the pericentral hepatocyte population throughout the whole liver. After injury recovery, the adult liver re-establishes the metabolic zonation by reprogramming the Mfsd2a+-derived hepatocytes into pericentral hepatocytes. The evidence of entire zonation replacement during injury increases our understanding of liver biology and disease.
Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration
Wenjuan Pu,1,2 Hui Zhang,1,2 Xiuzhen Huang,1,2 Xueying Tian,1,2 Lingjuan He,1,2 Yue Wang,1,2 Libo Zhang,1,2 Qiaozhen Liu,1,2 Yan Li,1,2 Yi Li,1,2 Huan Zhao,1,2 Kuo Liu,1 Jie Lu,3 Yingqun Zhou,3 Pengyu Huang,4 Yu Nie,5 Yan Yan,6 Lijian Hui,2,4 Kathy O. Lui,7 and Bin Zhoua,1,2,4,8,9
Drosophila mojavensis adults, which breed and feed on necrotic cacti, show an increase in longevity when exposed to atmospheric ethanol. The increase in longevity is accompanied by retention of mature ovarioles and is independent of diet. Differences in longevity among strains from different localities were detected for females. Strains from Arizona and Sonora, Mexico, showed the greatest increase in longevity, while strains from Baja California, Mexico, showed the least increase. These differences may be controlled by the alcohol dehydrogenase locus, the octanol dehydrogenase locus, and modifier genes, because the aduld response is correlated with the frequency of alcohol dehydrogenase alleles, as well as second chromosomal inversions containing the octanol dehydrogenase locus. The longevity response is also consistent with the more uneven distribution and availability of the host plant in Arizona and Sonora, Mexico. Strains from Arizona and Sonora, Mexico, have a high frequency of Adh-S, the allele whose product is heat and pH tolerant. The host plant, organpipe cactus, exhibits extremes in temperature and pH in the same geographic region. Strains from Baja California, Mexico, possess a high frequency of Adh-F, whose product is heat and pH sensitive. The substrate in this region, agria cactus, has moderate temperature and pH extremes and contains relatively high concentrations of isopropanol. Isopropanol is presumable a selective agen favorable to Adh-F. The environmental heterogeneity that is proposed for maintaining the alleles at the alcohol dehydrogenase locus is the interaction of substrate alcohol content with temperature and pH. Substrates that do not contain appreciable amounts of isopropanol and are exposed to high temperatures and exhibit variable pH favor Adh-S, while substrates containing isopropanol and having moderate temperatures and pH favor Adh-F.
Extension of longevity in Drosophila mojavensis by environmental ethanol: differences between subraces.
W T Starmer, W B Heed, and E S Rockwood-Sluss
Stereoselective [2,3]-Wittig rearrangement of E- and Z-allylic stannyl ethers derived from an isopropylidene L-threitol derivative has been investigated. The E-isomer exhibited best diastereoselectivity and the resulting rearrangement product has been converted to protected polyoxamic acid, an amino acid component of many bioactive polyoxins.
amino acids and derivatives, carbamates rearrangement, stereoselection, tin and compounds
Stereoselective Synthesis of 5-O-Carbamoylpolyoxamic Acid by [2,3]-Wittig-Still Rearrangement
Arun K. Ghosh and Yong Wang
2018 Nov 5.