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  • Brand : BIOFRON

  • Catalogue Number : BF-D3012

  • Specification : 98%

  • CAS number : 19130-96-2

  • Formula : C6H13NO4

  • Molecular Weight : 163.17

  • PUBCHEM ID : 29435

  • Volume : 25mg

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Catalogue Number


Analysis Method






Molecular Weight



White crystalline powder

Botanical Source

Morus alba

Structure Type



Standards;Natural Pytochemical;API




(2R,3R,4R,5S)-2-Hydroxymethyl-3,4,5-trihydroxypiperidine/3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-/D-5-Amino-1,5-dideoxyglucopyranose/deoxynojirimycin/MORANOLINE/(2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol/Duvoglustat/(2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol/1,5-Dideoxy-1,5-imino-D-glucitol/(+)-1-deoxynojirimycin/1-Deoxy-Nojirimycin/desoxynojirimycin/(2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol/S-GI/[2R-(2a,3b,4a,5b)]-2-(Hydroxymethyl)-3,4,5-piperidinetriol/nojirimycin, deoxy-




1.5±0.1 g/cm3


Methanol; Water

Flash Point

197.3±18.5 °C

Boiling Point

361.1±42.0 °C at 760 mmHg

Melting Point



InChl Key

WGK Germany


HS Code Reference


Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:19130-96-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate




1-Deoxynojirimycin (DNJ, C₆H13NO₄, 163.17 g/mol), an alkaloid azasugar or iminosugar, is a biologically active natural compound that exists in mulberry leaves and Commelina communis (dayflower) as well as from several bacterial strains such as Bacillus and Streptomyces species. Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features. Therefore, the aim of this detailed review article is to summarize the existing knowledge on occurrence, extraction, purification, determination, chemistry, and bioactivities of DNJ, so that researchers may use it to explore future perspectives of research on DNJ. Moreover, possible molecular targets of DNJ will also be investigated using suitable in silico approach.


Bacillus; anti-obesity; antihyperglycemic; antiviral; fermentation; iminosugar; molecular targets; mulberry; silkworms.


1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing


Kuo Gao 1 , Chenglong Zheng 2 3 , Tong Wang 4 , Huihui Zhao 5 , Juan Wang 6 , Zhiyong Wang 7 , Xing Zhai 8 , Zijun Jia 9 , Jianxin Chen 10 , Yingwu Zhou 11 , Wei Wang 12

Publish date

2016 Nov 23




The present study investigated the effect of 1-Deoxynojirimycin (DNJ) on liver injury and hepatic glucose metabolism in db/db mice. Mice were divided into five groups: normal control, db/db control, DNJ-20 (DNJ 20 mg·kg(-1)·day(-1)), DNJ-40 (DNJ 40 mg·kg(-1)·day(-1)) and DNJ-80 (DNJ 80 mg·kg(-1)·day(-1)). All doses were treated intravenously by tail vein for four weeks. DNJ was observed to significantly reduce the levels of serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and liver TG, as well as activities of serum alanine aminotransferase (ALT), and aspartate transaminase (AST); DNJ also alleviated macrovesicular steatosis and decreased tumor necrosis factor α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) levels in liver tissue. Furthermore, DNJ treatment significantly increased hepatic glycogen content, the activities of hexokinase (HK), pyruvate kinase (PK) in liver tissue, and decreased the activities of glucose-6-phosphatase (G6Pase), glycogen phosphorylase (GP), and phosphoenolpyruvate carboxykinase (PEPCK). Moreover, DNJ increased the phosphorylation of phosphatidylinositol 3 kinase (PI3K) on p85, protein kinase B (PKB) on Ser473, glycogen synthase kinase 3β (GSK-3β) on Ser9, and inhibited phosphorylation of glycogen synthase (GS) on Ser645 in liver tissue of db/db mice. These results demonstrate that DNJ can increase hepatic insulin sensitivity via strengthening of the insulin-stimulated PKB/GSK-3β signal pathway and by modulating glucose metabolic enzymes in db/db mice. Moreover, DNJ also can improve lipid homeostasis and attenuate hepatic steatosis in db/db mice.


Bacillus; anti-obesity; antihyperglycemic; antiviral; fermentation; iminosugar; molecular targets; mulberry; silkworms.


1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in Db/Db Mice


Qingpu Liu 1 , Xuan Li 2 , Cunyu Li 3 4 , Yunfeng Zheng 5 6 , Fang Wang 7 , Hongyang Li 8 , Guoping Peng 9 10

Publish date

2016 Feb 27




1-Deoxynojirimycin sustained-release pellets, which exhibit known release and absorption profiles, are used for the treatment of diabetes mellitus. In this study, a fluidised bed coater was employed to prepare new, drug-loaded pellets. In the dissolution test, it was found that 1-DNJ pellets exhibited a sustained release effect after being coated with hydroxypropyl methyl cellulose phthalate-55 S. For sustained-release pellets and immediate-release pellets, there was significant difference in the mean cumulative drug concentration profile in different media evaluation. In the bioavailability study, the ratio of mean relative bioavailability of the SR pellets to the IR tablets was calculated by the DAS from the AUC0-24 h of 1-DNJ and was found to be 117.3%. This suggested that the behaviour in vivo of the 1-DNJ SR pellets was superior to the IR tablets, which indicated the designed preparation method of the 1-DNJ SR pellets was acceptable for achieving sustained release of 1-DNJ with enhanced bioavailability.


1-deoxynojirimycin; Hydroxypropyl methyl cellulose phthalate; bioavailability; immediate-release tablets; sustained-release pellets; vitro evaluation.


Preparation and Evaluation of 1-deoxynojirimycin Sustained-Release Pellets vs Conventional Immediate-Release Tablets


Zhaoying Sun 1 2 , Shujie Yuan 2 , Huanan Zhao 3 , Zhenyang Wang 1 , Zhiming Liu 1

Publish date

2017 May

Description :

1-Deoxynojirimycin (DNJ, Duvoglustat) is a potent α-glucosidase inhibitor, suppresses postprandial blood glucose, thereby possibly preventing diabetes mellitus. Target: α-glucosidase1-Deoxynojirimycin is an alpha-glucosidase inhibitor, most commonly found in mulberry leaves. Although it can be obtained in small quantities by brewing an herbal tea from mulberry leaves, interest in commercial production has led to research on developing mulberry tea higher in DNJ, and on alternate routes of production, such as via Bacillusspecies.