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  • Brand : BIOFRON

  • Catalogue Number : BN-O0307

  • Specification : 95%(HPLC)

  • CAS number : 22048-98-2

  • Formula : C15H19NO

  • Molecular Weight : 229.323

  • PUBCHEM ID : 21709636

  • Volume : 20MG

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Catalogue Number


Analysis Method






Molecular Weight




Botanical Source

This product is isolated and purified from the fruits of Evodia rutaecarpa.

Structure Type



Standards;Natural Pytochemical;API




1-phenyl-d5-2-aminopropane /1-Methyl-2-para-chlorophenylaziridine /MPCPA /4(1H)-Quinolinone, 1-methyl-2-pentyl- /1-Methyl-2-p-chlorphenyl-aziridin /1-Methyl-2-p-chlorophenylaziridine /1-Methyl-2-pentyl-4(1H)-quinolinone /insoluble DMSO /1-methyl-2-pentyl-1H-quinolin-4-one /1-methyl-2-pentadeuteriophenyl-ethylamine /1-Methyl-2-pentyl-1H-chinolin-4-on





1.0±0.1 g/cm3


Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

115.3±17.3 °C

Boiling Point

332.1±42.0 °C at 760 mmHg

Melting Point


InChl Key


WGK Germany


HS Code Reference


Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:22048-98-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




In recent years, cardiac glycosides (CGs) have been investigated as potential antiviral and anticancer drugs. Digitoxigenin (DIG) and other CGs have been shown to bind and inhibit Na+/K+-adenosinetriphosphatase (ATPase). Tumor cells show a higher expression rate of the Na+/K+-ATPase protein or a stronger affinity towards the binding of CGs and are therefore more prone to CGs than non-tumor cells. Cancer imaging techniques using radiotracers targeted at specific receptors have yielded successful results. Technetium-99m (99mTc) is one of the radionuclides of choice to radiolabel pharmaceuticals because of its favorable physical and chemical properties along with reasonable costs. Herein, we describe a new Na+/K+-ATPase targeting radiotracer consisting of digitoxigenin and diethylenetriaminepentaacetic acid (DTPA), a bifunctional chelating ligand used to prepare 99mTc-labeled complexes, and its evaluation as an imaging probe. We report the synthesis and characterization of the radiolabeled compound including stability tests, blood clearance, and biodistribution in healthy mice. Additionally, we investigated the binding of the compound to A549 human non-small-cell lung cancer cells and the inhibition of the Na+/K+-ATPase by the labeled compound in vitro. The 99mTc-labeled DTPA-digitoxigenin (99mTc-DTPA-DIG) compound displayed high stability in vitro and in vivo, a fast renal excretion, and a specific binding towards A549 cancer cells in comparison to non-tumor cells. Therefore, 99mTc-DTPA-DIG could potentially be used for non-invasive visualization of tumor lesions by means of scintigraphic imaging.


New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification


Jennifer Munkert,corresponding author*† Eliza R. Gomes,‡ Lucas L. Marostica,∥ Betania B. Cota,⊥ Cristina L. M. Lopes,‡ Saulo F. Andrade,# Jose D. de Souza Filho,§ Ricardo J. Alves,‡ Monica C. Oliveira,‡ Fernão C. Braga,‡ Claudia M. O. Simões,∥ Rodrigo M. Padua,corresponding author*‡ and Andre L. B. de Barroscorresponding author‡

Publish date

2019 Dec 24




The high prevalence of diabetes is associated with body mass index (BMI), and diabetes can cause many complications, such as hip fractures. This study investigated the effects of BMI and diabetes on the risk of hip fractures and related factors.

We retrospectively reviewed data from 22,048 subjects aged ≧ 40 years from the National Health Interview Survey in Taiwan (NHIST) in 2001, 2005, and 2009. We linked the NHIST data for individual participants with the National Health Insurance Research Database (NHIRD), which includes the incidence of hip fracture from 2000 to 2013. We defined five categories for BMI: low BMI (BMI < 18.5), normal BMI (18.5 ≦ BMI < 24), overweight (24 ≦ BMI < 27), mild obesity (27 ≦ BMI < 30), and moderate obesity (BMI ≧ 30). The Cox proportional hazards model was used to analyze the effects of BMI and diabetes on risk of hip fracture. Results The Cox proportional hazards model shows that hip fracture risk in participants with diabetes was 1.64 times that of non-diabetes patients (95% confidence interval [CI]:1.30-2.15). Participants with low BMIs showed a higher hip fracture risk (HR: 1.75) than those with normal BMI. Among the five BMI groups, compared with non-diabetes patients, only diabetes patients with a normal BMI showed a significantly higher risk on hip fracture (HR: 2.13, 95% CI: 1.48-3.06). In participants with diabetes, compared with those with normal BMI, those with overweight or obesity showed significantly lower hip fracture risks (HR: 0.49 or 0.42). The hip fracture risk in participants who expend ≧ 500 kcal/week in exercise was 0.67 times lower than in those who did not exercise. Conclusions Diabetes and low BMI separately are important risk factors for hip fracture. There was an interaction between diabetes and BMI in the relationship with hip fracture (p = 0.001). The addition of energy expenditure through exercise could effectively decrease hip fracture risk, regardless of whether the participants have diabetes or not. The results of this study could be used as a reference for health promotion measures for people with diabetes.


BMI, Body mass index, Hip fracture, Diabetes, National Health Insurance


Associations of body mass index and diabetes with hip fracture risk: a nationwide cohort study


Hsiu-Ling Huang,#1,2 Cheng-Chin Pan,#3 Yu-Fen Hsiao,1 Ming-Chih Chen,4 Chuan-Yu Kung,5 Pei-Tseng Kung,6,7 and Wen-Chen Tsaicorresponding author2

Publish date





Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015


Jerry W. Shay,corresponding author1 Noriko Homma,2 Ruyun Zhou,2 Muhammad Imran Naseer,3 Adeel G. Chaudhary,3 Mohammed Al-Qahtani,3 Nobutaka Hirokawa,corresponding author2,3 Maryam Goudarzi,4 Albert J. Fornace, Jr.,corresponding author4,5,6,7 Saleh Baeesa,8 Deema Hussain,corresponding author8 Mohammed Bangash,8 Fahad Alghamdi,8 Hans-Juergen Schulten,8 Angel Carracedo,8 Ishaq Khan,8 Hanadi Qashqari,8 Nawal Madkhali,8 Mohamad Saka,8 Kulvinder S. Saini,8 Awatif Jamal,8 Jaudah Al-Maghrabi,8 Adel Abuzenadah,8 Adeel Chaudhary,8 Mohammed Al Qahtani,8 Ghazi Damanhouri,8 Heba Alkhatabi,corresponding author9 Anne Goodeve,corresponding author10 Laura Crookes,10 Nikolas Niksic,10 Nicholas Beauchamp,10 Adel M. Abuzenadah,corresponding author11 Jim Vaught,corresponding author12 Bruce Budowle,corresponding author13,14 Mourad Assidi,14 Abdelbaset Buhmeida,14 Jaudah Al-Maghrabi,corresponding author15 Abdelbaset Buhmeida,corresponding author16 Mourad Assidi,16 Leena Merdad,17 Sudhir Kumar,corresponding author18 Sayaka Miura,18 Karen Gomez,18 Angel Carracedo,19 Mahmood Rasool,20 Ahmed Rebai,corresponding author21 Sajjad Karim,corresponding author22 Hend F. Nour Eldin,22 Heba Abusamra,22 Elham M. Alhathli,22 Nada Salem,22 Mohammed H. Al-Qahtani,22 Sudhir Kumar,22,23 Hossam Faheem,corresponding author24 Ashok Agarwa,corresponding author25,26 Eberhard Nieschlag,corresponding author27,28 Joachim Wistuba,27 Oliver S. Damm,27 Mohd A. Beg,28 Taha A. Abdel-Meguid,29 Hisham A. Mosli,29 Osama S. Bajouh,30 Adel M. Abuzenadah,28,31 Mohammed H. Al-Qahtani,28 Serdar Coskun,corresponding author32 Muhammad Abu-Elmagd,corresponding author33,34 Abdelbaset Buhmeida,33,34 Ashraf Dallol,33,34 Jaudah Al-Maghrabi,35 Sahar Hakamy,33 Wejdan Al-Qahtani,33 Asia Al-Harbi,33 Shireen Hussain,33 Mourad Assidi,33,34 Mohammed Al-Qahtani,33,34 Adel Abuzenadah,33,34 Burak Ozkosem,corresponding author36 Rick DuBois,37 Safia S. Messaoudi,corresponding author38 Maryam T. Dandana,39 Touhami Mahjoub,39 Wassim Y. Almawi,40 S. Abdalla,corresponding author41 M. Nabil Al-Aama,42 Asmaa Elzawahry,43 Tsuyoshi Takahashi,44 Sachiyo Mimaki,45 Eisaku Furukawa,43 Rie Nakatsuka,44 Isao Kurosaka,43 Takahiko Nishigaki,44 Hiromi Nakamura,46 Satoshi Serada,46 Tetsuji Naka,47 Seiichi Hirota,48 Tatsuhiro Shibata,47 Katsuya Tsuchihara,45 Toshirou Nishida,49 Mamoru Kato,corresponding author43 Sajid Mehmood,corresponding author50 Naeem Mahmood Ashraf,50 Awais Asif,50 Muhammad Bilal,50 Malik Siddique Mehmood,50 Aadil Hussain,50 Qazi Mohammad Sajid Jamal,corresponding author51 Mughees Uddin Siddiqui,51 Mohammad A. Alzohairy,52 Mohammad A. Al Karaawi,52 Taoufik Nedjadi,53 Jaudah Al-Maghrabi,54 Mourad Assidi,55 Heba Al-Khattabi,55 Adel Al-Ammari,56 Ahmed Al-Sayyad,57 Abdelbaset Buhmeida,corresponding author55 Mohammed Al-Qahtani,55 Hedia Zitouni,corresponding author58,59 Nozha Raguema,58,59 Marwa Ben Ali,58,59 Wided Malah,60 Raja Lfalah,60 Wassim Almawi,61 Touhami Mahjoub,58 Mohammed Elanbari,62 Andrey Ptitsyn,corresponding author62 Sana Mahjoub,corresponding author63 Rabeb El Ghali,63 Bechir Achour,63 Nidhal Ben Amor,63 Mourad Assidi,64 Brahim N’siri,63 Hamid Morjani,65 Taoufik Nedjadi,corresponding author66 Adel Al-Ammari,67 Ahmed Al-Sayyad,68 Nada Salem,69 Esam Azhar,66 Jaudah Al-Maghrabi,70 Vera Chayeb,corresponding author71,72 Maryam Dendena,71 Hedia Zitouni,71,72 Khedija Zouari-Limayem,73,74 Touhami Mahjoub,71 Bassem Refaat,corresponding author75 Ahmed M. Ashshi,75 Sarah A. Batwa,76 Hazem Ramadan,corresponding author77 Amal Awad,78 Ahmed Ateya,79 Adel Galal Ahmed El-Shemi,corresponding author80,81 Ahmad Ashshi,80 Mohammed Basalamah,80 Youjin Na,81 Chae-Ok Yun,82 Adel Galal Ahmed El-Shemi,corresponding author83 Ahmad Ashshi,83 Mohammed Basalamah,83 Youjin Na,83 Chae-Ok Yun,83 Adel Galal El-Shemi,corresponding author84,85 Bassem Refaat,84 Osama Kensara,86 Amr Abdelfattah,84 Batol Imran Dheeb,corresponding author87 Mohammed M. F. Al-Halbosiy,88 Rghad Kadhim Al lihabi,88 Basim Mohammed Khashman,89 Djouhri Laiche,90 Chaudhary Adeel,91 Nedjadi Taoufik,corresponding author92 Hani Al-Afghani,corresponding author93,94 Maria Łastowska,93 Haya H. Al-Balool,93 Harsh Sheth,93 Emma Mercer,93 Jonathan M. Coxhead,93 Chris P. F. Redfern,93 Heiko Peters,93 Alastair D. Burt,93 Mauro Santibanez-Koref,93 Chris M. Bacon,93 Louis Chesler,93 Alistair G. Rust,93 David J. Adams,93 Daniel Williamson,93 Steven C. Clifford,93 Michael S. Jackson,93 Mala Singh,95 Mohmmad Shoab Mansuri,95 Shahnawaz D. Jadeja,95 Hima Patel,95 Yogesh S. Marfatia,96 Rasheedunnisa Begum,corresponding author95 Amal M. Mohamed,corresponding author97 Alaa K. Kamel,97 Nivin A. Helmy,97 Sayda A. Hammad,97 Hesham F. Kayed,97 Marwa I. Shehab,97 Assad El Gerzawy,97 Maha M. Ead,97 Ola M. Ead,97 Mona Mekkawy,97 Innas Mazen,98 Mona El-Ruby,98 S. M. A. Shahid,corresponding author99 Qazi Mohammad Sajid Jamal,100 J. M. Arif,99 Mohtashim Lohani,101 Moumni Imen,corresponding author102 Chaouch Leila,102 Ouragini Houyem,102 Douzi Kais,102 Chaouachi Dorra Mellouli Fethi,103 Bejaoui Mohamed,103 Abbes Salem,102 Areeg Faggad,corresponding author104,105 Amanuel T. Gebreslasie,105,106 Hani Y. Zaki,105 Badreldin E. Abdalla,105,107 Maha S. AlShammari,corresponding author108 Rhaya Al-Ali,108 Nader Al-Balawi,108 Mansour Al-Enazi,108 Ali Al-Muraikhi,108 Fadi Busaleh,108 Ali Al-Sahwan,108 Francis Borgio,108 Abdulazeez Sayyed,108 Amein Al-Ali,108 Sadananda Acharya,108 Maha S. Zaki,109 Hala T. El-Bassyouni,corresponding author109 Marwa I. Shehab,110 Mohammed F. Elshal,corresponding author111 Kaleemuddin M.,111 Alia M. Aldahlawi,112 Omar Saadah,113 J. Philip McCoy,114 Adel E. El-Tarras,115 Nabil S. Awad,116,117 Abdulla A. Alharthi,115 Mohamed M. M. Ibrahim,corresponding author117 Haneen S. Alsehli,118,119 Ashraf Dallol,119 Abdullah M. Gari,120 Mohammed M. Abbas,118,121 Roaa A. Kadam,122 Mazen M. Gari,122 Mohmmed H. Alkaff,118,121 Adel M. Abuzenadah,119,123 Mamdooh A. Gari,corresponding author118,119,123 Heba Abusamra,477 Sajjad Karim,corresponding author124 Hend F. Nour eldin,124 Elham M. Alhathli,124 Nada Salem,124 Sudhir Kumar,124,125 Mohammed H. Al-Qahtani,124 Fatima A. Moradi,126,127 Omran M. Rashidi,127 Zuhier A. Awan,corresponding author128 Ibrahim Hamza Kaya,129 Olfat Al-Harazi,130 Dilek Colak,corresponding author130 Nabila A. Alkousi,corresponding author131 Takis Athanasopoulos,131 Afnan O. Bahmaid,132 Etimad A. Alhwait,132 Mamdooh A. Gari,133,134,135 Haneen S. Alsehli,136 Mohammed M. Abbas,134,137 Mohammed H. Alkaf,134,137 Roaa Kadam,135 Ashraf Dallol,136 Gauthaman Kalamegam,corresponding author134,135 Hend F. Nour Eldin,138 Sajjad Karim,corresponding author138 Heba Abusamra,138 Elham Alhathli,138 Nada Salem,138 Mohammed H. Al-Qahtani,138 Sudhir Kumar,138,139 Salma N. Alsayed,corresponding author140 Fawziah H. Aljohani,140 Samaher M. Habeeb,140 Rawan A. Almashali,140 Sulman Basit,141 Samia M. Ahmed,140 Rakesh Sharma,142 Ashok Agarwal,corresponding author142 Damayanthi Durairajanayagam,142,143 Luna Samanta,142,144 Muhammad Abu-Elmagd,145,146 Adel M. Abuzenadah,145,146 Edmund S. Sabanegh,147 Mourad Assidi,145,146 Mohammed Al-Qahtani,145 Ashok Agarwal,corresponding author148 Rakesh Sharma,148 Luna Samanta,148,149 Damayanthi Durairajanayagam,148,150 Mourad Assidi,151,152 Muhammad Abu-Elmagd,151,152 Mohammed Al-Qahtani,151 Adel M. Abuzenadah,151,152 Edmund S. Sabanegh,153 Luna Samanta,154,155 Ashok Agarwal,corresponding author154 Rakesh Sharma,154 Zhihong Cui,154,156 Mourad Assidi,157,158 Adel M. Abuzenadah,157,158 Muhammad Abu-Elmagd,157,158 Mohammed Al-Qahtani,157 Alaa A. Alboogmi,159 Nuha A. Alansari,159 Maha M. Al-Quaiti,159 Fai T. Ashgan,159 Afnan Bandah,159 Hasan S. Jamal,160 Abdullraheem Rozi,160 Zeenat Mirza,161 Adel M. Abuzenadah,159 Sajjad Karim,corresponding author159 Mohammed H. Al-Qahtani,159 Sajjad Karim,corresponding author162 Hans-Juergen Schulten,162 Ahmad J. Al Sayyad,163 Hasan M. A. Farsi,163 Jaudah A. Al-Maghrabi,164,165 Zeenat Mirza,166 Reem Alotibi,162 Alaa Al-Ahmadi,162 Nuha A. Alansari,162 Alaa A. Albogmi,162 Maha M. Al-Quaiti,162 Fai T. Ashgan,162 Afnan Bandah,162 Mohammed H. Al-Qahtani,162 Rasha A. Ebiya,corresponding author167,168 Samia M. Darwish,167,168 Metwally M. Montaser,169,170 Heba Abusamra,171,172 Vladimir B. Bajic,corresponding author173 Jaudah Al-Maghrabi,corresponding author174 Wafaey Gomaa,174,175 Mehenaz Hanbazazh,174 Mahmoud Al-Ahwal,176 Asia Al-Harbi,177 Wejdan Al-Qahtani,177 Saher Hakamy,177 Ghali Baba,177 Abdelbaset Buhmeida,177 Mohammed Al-Qahtani,177 Jaudah Al-Maghrabi,178 Abdullah Al-Harbi,178 Mahmoud Al-Ahwal,179 Asia Al-Harbi,180 Wejdan Al-Qahtani,180 Sahar Hakamy,180 Ghalia Baba,180 Abdelbaset Buhmeida,180 Mohammed Al-Qahtani,180 Elham M. Alhathli,181 Sajjad Karim,corresponding author181 Nada Salem,181 Hend Nour Eldin,181 Heba Abusamra,181 Sudhir Kumar,181,182 Mohammed H. Al-Qahtani,181 Aisha A. Alyamani,183 Gauthaman Kalamegam,corresponding author184,185 Etimad A. Alhwait,183 Mamdooh A. Gari,184,185,186 Mohammed M. Abbas,185,187 Mohammed H. Alkaf,185,187 Haneen S. Alsehli,188 Roaa A. Kadam,184 Mohammed Al-Qahtani,184 Rawan Gadi,189 Abdelbaset Buhmeida,190 Mourad Assidi,190,191 Adeel Chaudhary,191 Leena Merdad,corresponding author192 Saadiah M. Alfakeeh,193 Etimad A. Alhwait,193 Mamdooh A. Gari,194,195,196 Mohammed M. Abbas,195,197 Mohammed H. Alkaf,195,197 Haneen S. Alsehli,198 Roaa Kadam,196 Gauthaman Kalamegam,corresponding author195,196 Rubi Ghazala,199 Shilu Mathew,200 M. Haroon Hamed,201 Mourad Assidi,201,202 Mohammed Al-Qahtani,200 Ishtiaq Qadri,corresponding author203 Shilu Mathew,204 Lobna Mira,204 Manal Shaabad,204 Shireen Hussain,204 Mourad Assidi,corresponding author204,205 Muhammad Abu-Elmagd,204 Mohammed Al-Qahtani,204 Shilu Mathew,206 Manal Shaabad,206 Lobna Mira,206 Shireen Hussain,206 Mourad Assidi,corresponding author206,207 Muhammad Abu-Elmagd,206 Mohammed Al-Qahtani,206 Ahmed Rebai,corresponding author208 Mourad Assidi,209,210 Abdelbaset Buhmeida,209 Muhammad Abu-Elmagd,209,210 Ashraf Dallol,209,210 Jerry W. Shay,209,211 Mikhlid H. Almutairi,corresponding author212 Angie Ambers,213 Jennifer Churchill,213 Jonathan King,213 Monika Stoljarova,213,214 Harrell Gill-King,215 Mourad Assidi,216 Muhammad Abu-Elmagd,216 Abdelbaset Buhmeida,216 Muhammad Al-Qatani,216 Bruce Budowle,corresponding author213,216 Muhammad Abu-Elmagd,corresponding author217,218 Farid Ahmed,217 Ashraf Dallol,217,218 Mourad Assidi,217,218 Taha Abo Almagd,219 Sahar Hakamy,217 Ashok Agarwal,220 Muhammad Al-Qahtani,217 Adel Abuzenadah,217,218 Sajjad Karim,corresponding author221 Hans-Juergen Schulten,221 Ahmad J. Al Sayyad,222 Hasan M. A. Farsi,222 Jaudah A. Al-Maghrabi,223,224 Abdelbaset Buhmaida,221 Zeenat Mirza,225 Reem Alotibi,221 Alaa Al-Ahmadi,221 Nuha A. Alansari,221 Alaa A. Albogmi,221 Maha M. Al-Quaiti,221 Fai T. Ashgan,221 Afnan Bandah,221 Mohammed H. Al-Qahtani,221 Rukhsana Satar,226 Mahmood Rasool,227 Waseem Ahmad,227 Nazia Nazam,228 Mohamad I. Lone,228 Muhammad I. Naseer,227,229 Mohammad S. Jamal,229 Syed K. Zaidi,227 Peter N. Pushparaj,227 Mohammad A. Jafri,227 Shakeel A. Ansari,corresponding author227 Mohammed H. Alqahtani,227 Hanan Bashier,230 Abrar Al Qahtani,230 Shilu Mathew,230 Amal M. Nour,230 Heba Alkhatabi,230 Adel M. Abu Zenadah,230 Abdelbaset Buhmeida,230 Mourad Assidi,corresponding author230 Muhammed Al Qahtani,230 Muhammad Faheem,231 Shilu Mathew,232 Shiny Mathew,233 Peter Natesan Pushparaj,corresponding author232 Mohammad H. Al-Qahtani,232 Hani A. Alhadrami,corresponding author234,235 Ashraf Dallol,235 Adel Abuzenadah,234,235 Ibtessam R. Hussein,corresponding author236 Adeel G. Chaudhary,236,237 Rima S. Bader,238 Randa Bassiouni,239 Maha Alquaiti,236 Fai Ashgan,236 Hans Schulten,236 Mohamed Nabil Alama,240 Mohammad H. Al Qahtani,236,237,238 Mohammad I. Lone,corresponding author241 Nazia Nizam,241 Waseem Ahmad,242 Mohammad A. Jafri,242 Mahmood Rasool,242 Shakeel A. Ansari,242 Muhammed H. Al-Qahtani,242 Eradah Alshihri,243 Muhammad Abu-Elmagd,corresponding author244,245 Lina Alharbi,243 Mourad Assidi,244,245 Mohammed Al-Qahtani,243,244 Shilu Mathew,246 Peter Pushparaj Natesan,corresponding author246 Muhammed Al Qahtani,246 Gauthaman Kalamegam,corresponding author247 Peter Natesan Pushparaj,247 Fazal Khan,248 Roaa Kadam,247 Farid Ahmed,247 Mourad Assidi,247 Khalid Hussain Wali Sait,249 Nisreen Anfinan,249 Mohammed Al Qahtani,247 Muhammad I. Naseer,250 Adeel G. Chaudhary,250 Mohammad S. Jamal,251 Shilu Mathew,250 Lobna S. Mira,250 Peter N. Pushparaj,250 Shakeel A. Ansari,250 Mahmood Rasool,corresponding author250 Mohammed H. AlQahtani,250 Muhammad I. Naseer,252 Adeel G. Chaudhary,252 Shilu Mathew,252 Lobna S. Mira,252 Mohammad S. Jamal,252 Sameera Sogaty,252 Randa I. Bassiouni,252 Mahmood Rasool,corresponding author252,253,254,255 Mohammed H. AlQahtani,252 Mahmood Rasool,corresponding author256 Shakeel A. Ansari,256 Mohammad S. Jamal,257 Peter N. Pushparaj,256 Abdulrahman M. S. Sibiani,258 Waseem Ahmad,256 Abdelbaset Buhmeida,256 Mohammad A. Jafri,256 Mohiuddin K. Warsi,259 Muhammad I. Naseer,256 Mohammed H. Al-Qahtani,256 Rubi,260 Kundan Kumar,260 Ahmad A. T. Naqvi,261 Faizan Ahmad,261 Md I. Hassan,corresponding author261 Mohammad S. Jamal,262 Mahmood Rasool,263 Mohammed H. AlQahtani,263 Ashraf Ali,264 Jummanah Jarullah,264 Mahmood Rasool,265 Abdelbasit Buhmeida,265 Shahida Khan,264 Ghufrana Abdussami,266 Maryam Mahfooz,266 Mohammad A. Kamal,264 Ghazi A. Damanhouri,264 Mohammad S. Jamal,corresponding author264 Bushra Jarullah,267 Jummanah Jarullah,268 Mohammad S. S. Jarullah,269 Ashraf Ali,268 Mahmood Rasool,270 Mohammad S. Jamal,corresponding author268 Mourad Assidi,corresponding author271,272 Muhammad Abu-Elmagd,271,272 Osama Bajouh,272,273 Peter Natesan Pushparaj,271 Mohammed Al-Qahtani,271 Adel Abuzenadah,271,272,274 Mohammad S. Jamal,corresponding author275 Jummanah Jarullah,275 Abdulah E. A. Mathkoor,275 Hashim M. A. Alsalmi,275 Anas M. M. Oun,276 Ghazi A. Damanhauri,275 Mahmood Rasool,277 Mohammed H. AlQahtani,277 Muhammad I. Naseer,corresponding author278 Mahmood Rasool,278 Sameera Sogaty,279 Adeel G. Chudhary,278 Yousif A. Abutalib,280 Daniele Merico,281 Susan Walker,281 Christian R. Marshall,281 Mehdi Zarrei,281 Stephen W. Scherer,278,281,282 Mohammad H. Al-Qahtani,278 Muhammad I. Naseer,corresponding author283 Muhammad Faheem,284 Adeel G. Chaudhary,283 Mahmood Rasool,283 Gauthaman Kalamegam,283 Fai Talal Ashgan,283 Mourad Assidi,283 Farid Ahmed,283 Syed Kashif Zaidi,283 Mohammed M. Jan,285 Mohammad H. Al-Qahtani,283 Maryam Al-Zahrani,286 Sahira Lary,286 Sahar Hakamy,287 Ashraf Dallol,287 Mahmoud Al-Ahwal,288 Jaudah Al-Maghrabi,289 Emmanuel Dermitzakis,290 Adel Abuzenadah,287 Abdelbaset Buhmeida,corresponding author287 Mohammed Al-Qahtani,287 Abeer A. Al-refai,corresponding author291,294 Mona Saleh,291 Rehab I. Yassien,292 Mahmmoud Kamel,292 Rabab M. Habeb,293 Najlaa Filimban,295 Ashraf Dallol,corresponding author295,296 Nadia Ghannam,297 Mohammed Al-Qahtani,296 Adel Mohammed Abuzenadah,295,296,298 Fehmida Bibi,corresponding author299 Sana Akhtar,299 Esam I. Azhar,299,300 Muhammad Yasir,299 Muhammad I. Nasser,301 Asif A. Jiman-Fatani,302 Ali Sawan,303 Ruaa A. Lahzah,corresponding author304 Asho Ali,304 Syed A. Hassan,corresponding author305 Seyed E. Hasnain,306 Iftikhar A. Tayubi,305 Hamza A. Abujabal,307 Alaa O. Magrabi,308 Fazal Khan,309,310,311 Gauthaman Kalamegam,corresponding author309 Peter Natesan Pushparaj,309 Adel Abuzenada,309,310 Taha Abduallah Kumosani,311 Elie Barbour,312,313 Mohammed Al-Qahtani,309 Manal Shabaad,314 Shilu Mathew,314 Ashraf Dallol,314 Adnan Merdad,315 Abdelbaset Buhmeida,corresponding author314 Mohammed Al-Qahtani,314 Mourad Assidi,316,317 Muhammad Abu-Elmagd,316,317 Kalamegam Gauthaman,316 Mamdooh Gari,316 Adeel Chaudhary,316 Adel Abuzenadah,316 Peter Natesan Pushparaj,corresponding author316 Mohammed Al-Qahtani,316 Syed A. Hassan,corresponding author318 Iftikhar A. Tayubi,318 Hani M. A. Aljahdali,319 Reham Al Nono,320 Mamdooh Gari,320,321,322 Haneen Alsehli,323 Farid Ahmed,321 Mohammed Abbas,324 Gauthaman Kalamegam,corresponding author321 Mohammed Al-Qahtani,321 Shilu Mathew,325 Fazal Khan,325,326,327 Mahmood Rasool,325 Mohammed Sarwar Jamal,328 Muhammad Imran Naseer,325 Zeenat Mirza,328 Sajjad Karim,325 Shakeel Ansari,325 Mourad Assidi,325 Gauthaman Kalamegam,325 Mamdooh Gari,325 Adeel Chaudhary,325 Adel Abuzenadah,325 Peter Natesan Pushparaj,corresponding author325 Mohammed Al-Qahtani,325 Muhammad Abu-Elmagd,329,330 Gauthaman Kalamegam,corresponding author329 Roaa Kadam,329 Mansour A. Alghamdi,331 Magdy Shamy,331 Max Costa,332 Mamdouh I. Khoder,331 Mourad Assidi,329,330 Peter Natesan Pushparaj,329 Mamdooh Gari,329 Mohammed Al-Qahtani,329 Najla Kharrat,333 Sabrine Belmabrouk,333 Rania Abdelhedi,333 Riadh Benmarzoug,333 Mourad Assidi,334,335 Mohammed H. Al Qahtani,334 Ahmed Rebai,corresponding author333 Ghazi Dhamanhouri,336 Peter Natesan Pushparaj,337 Abdelwahab Noorwali,336 Mohammad Khalid Alwasiyah,337,338 Afnan Bahamaid,337,339 Saadiah Alfakeeh,337,339 Aisha Alyamani,337,339 Haneen Alsehli,340 Mohammed Abbas,341,342 Mamdooh Gari,337,341 Ali Mobasheri,337,343,344 Gauthaman Kalamegam,corresponding author337,341 Mohammed Al-Qahtani,337 Muhammad Faheem,345 Shilu Mathew,346 Peter Natesan Pushparaj,corresponding author346 Mohammad H. Al-Qahtani,346 Shilu Mathew,347 Muhammad Faheem,348 Shiny Mathew,349 Peter Natesan Pushparaj,corresponding author347 Mohammad H. Al-Qahtani,347 Mohammad Sarwar Jamal,350 Syed Kashif Zaidi,351 Raziuddin Khan,352 Kanchan Bhatia,352,353 Mohammed H. Al-Qahtani,352,353 Saif Ahmad,corresponding author352,353 Iftikhar AslamTayubi,corresponding author354 Manish Tripathi,355 Syed Asif Hassan,354 Rahul Shrivastava,355 Iftikhar A. Tayubi,corresponding author356 Syed Hassan,356 Hamza A. S. Abujabal,356 Ishani Shah,357 Bushra Jarullah,corresponding author357 Mohammad S. Jamal,358 Jummanah Jarullah,358 Ishfaq A. Sheikh,359 Ejaz Ahmad,359 Mohammad S. Jamal,359 Mohd Rehan,359 Muhammad Abu-Elmagd,360 Iftikhar A. Tayubi,361 Samera F. AlBasri,362 Osama S. Bajouh,362 Rola F. Turki,362,363 Adel M. Abuzenadah,360,363 Ghazi A. Damanhouri,359 Mohd A. Beg,corresponding author359 Mohammed Al-Qahtani,360 Sahar A. F. Hammoudah,corresponding author364,365 Khalid M. AlHarbi,365 Lama M. El-Attar,365,366 Ahmed M. Z. Darwish,367 Sara M. Ibrahim,368 Ashraf Dallol,369 Hani Choudhry,368,369 Adel Abuzenadah,369 Jalaludden Awlia,368 Adeel Chaudhary,370 Farid Ahmed,corresponding author370 Mohammed Al-Qahtani,370 Mohammad A. Jafri,corresponding author371 Muhammad Abu-Elmagd,371 Mourad Assidi,371 Mohammed Al-Qahtani,371 Imran khan,372 Muhammad Yasir,corresponding author373 Esam I. Azhar,373,374 Sameera Al-basri,375 Elie Barbour,376,377 Taha Kumosani,372 Fazal Khan,378,379,380,381,382 Gauthaman Kalamegam,corresponding author378 Peter Natesan Pushparaj,378 Adel Abuzenada,378,379 Taha Abduallah Kumosani,380,381,382 Elie Barbour,383,384 Heba M. EL Sayed,corresponding author385 Eman A. Hafez,386 Hans-Juergen Schulten,corresponding author387,388 Aisha Hassan Elaimi,387,388 Ibtessam R. Hussein,387,388 Randa Ibrahim Bassiouni,389 Mohammad Khalid Alwasiyah,387,390 Richard F. Wintle,391 Adeel Chaudhary,387,388 Stephen W. Scherer,391 Mohammed Al-Qahtani,387 Zeenat Mirza,corresponding author392,393 Vikram Gopalakrishna Pillai,393,394 Sajjad Karim,395 Sujata Sharma,393 Punit Kaur,393 Alagiri Srinivasan,393 Tej P. Singh,393 Mohammed Al-Qahtani,395 Reem Alotibi,396 Alaa Al-Ahmadi,396 Fatima Al-Adwani,396,397 Deema Hussein,398 Sajjad Karim,396,399 Mona Al-Sharif,397 Awatif Jamal,400 Fahad Al-Ghamdi,400 Jaudah Al-Maghrabi,400,401 Saleh S. Baeesa,402 Mohammed Bangash,402 Adeel Chaudhary,396,399 Hans-Juergen Schulten,corresponding author396,399 Mohammed Al-Qahtani,396,399 Muhammad Faheem,403 Peter Natesan Pushparaj,404 Shilu Mathew,403 Taha Abdullah Kumosani,403,405 Gauthaman Kalamegam,corresponding author404 Mohammed Al-Qahtani,404 Faisal A. Al-Allaf,406,407,408 Zainularifeen Abduljaleel,406,407 Abdullah Alashwal,409 Mohiuddin M. Taher,406,407 Abdellatif Bouazzaoui,406,407 Halah Abalkhail,409 Faisal A. Ba-Hammam,406 Mohammad Athar,corresponding author406,407 Gauthaman Kalamegam,410 Peter Natesan Pushparaj,410 Muhammad Abu-Elmagd,410,411 Farid Ahmed,410 Khalid HussainWali Sait,412 Nisreen Anfinan,412 Mamdooh Gari,410 Adeel Chaudhary,410 Adel Abuzenadah,410 Mourad Assidi,corresponding author410,411 Mohammed Al-Qahtani,410 Naira Ben Mami,corresponding author413 Yosr Z. Haffani,413 Mouna Medhioub,414 Lamine Hamzaoui,414 Ameur Cherif,413 Msadok Azouz,413,414 Gauthaman Kalamegam,415 Fazal Khan,416 Shilu Mathew,415 Mohammed Imran Nasser,415 Mahmood Rasool,415 Farid Ahmed,415 Peter Natesan Pushparaj,corresponding author415,417,418,419 Mohammed Al-Qahtani,415 Shereen A. Turkistany,corresponding author420 Lina M. Al-harbi,421 Ashraf Dallol,420,421 Jamal Sabir,422 Adeel Chaudhary,420,421,423 Adel Abuzenadah,420,421,423 Basmah Al-Madoudi,424 Bayan Al-Aslani,424 Khulud Al-Harbi,424 Rwan Al-Jahdali,424 Hanadi Qudaih,424 Emad Al Hamzy,424 Mourad Assidi,corresponding author424,425 Mohammed Al Qahtani,424 Asad M. Ilyas,426 Youssri Ahmed,426,427,428 Mamdooh Gari,429 Farid Ahmed,corresponding author429 Mohammed Alqahtani,429 Nada Salem,430 Sajjad Karim,corresponding author430 Elham M. Alhathli,430 Heba Abusamra,430 Hend F. Nour Eldin,430 Mohammed H. Al-Qahtani,430 Sudhir Kumar,431 Fatima Al-Adwani,432,433 Deema Hussein,434 Mona Al-Sharif,433 Awatif Jamal,435 Fahad Al-Ghamdi,435 Jaudah Al-Maghrabi,435,436 Saleh S. Baeesa,437 Mohammed Bangash,437 Adeel Chaudhary,432,438 Mohammed Al-Qahtani,432,438 Hans-Juergen Schulten,corresponding author432,438 Alaa Alamandi,439 Reem Alotibi,439 Deema Hussein,440 Sajjad Karim,439,441 Jaudah Al-Maghrabi,442,443 Fahad Al-Ghamdi,442 Awatif Jamal,442 Saleh S. Baeesa,444 Mohammed Bangash,444 Adeel Chaudhary,439,441 Hans-Juergen Schulten,corresponding author439,441 Mohammed Al-Qahtani,439,441 Ohoud Subhi,445 Nadia Bagatian,445 Sajjad Karim,445,446 Adel Al-Johari,447 Osman Abdel Al-Hamour,448 Hosam Al-Aradati,449 Abdulmonem Al-Mutawa,449 Faisal Al-Mashat,447 Jaudah Al-Maghrabi,449,450 Hans-Juergen Schulten,corresponding author445,446 Mohammad Al-Qahtani,445,446 Nadia Bagatian,451 Ohoud Subhi,451 Sajjad Karim,451,452 Adel Al-Johari,453 Osman Abdel Al-Hamour,454 Abdulmonem Al-Mutawa,455 Hosam Al-Aradati,455 Faisal Al-Mashat,453 Mohammad Al-Qahtani,451,452 Hans-Juergen Schulten,corresponding author451,452 Jaudah Al-Maghrabi,455,456 Muhammad W. shah,457 Muhammad Yasir,corresponding author458 Esam I Azhar,458,459 Saad Al-Masoodi,457 Yosr Z. Haffani,corresponding author460 Msadok Azouz,460,461 Emna Khamla,460 Chaima Jlassi,460 Ahmed S. Masmoudi,460 Ameur Cherif,460 Lassaad Belbahri,462 Shadi Al-Khayyat,463,464 Roba Attas,465 Atlal Abu-Sanad,463 Mohammed Abuzinadah,464,466 Adnan Merdad,463 Ashraf Dallol,464 Adeel Chaudhary,467 Mohammed Al-Qahtani,467 Adel Abuzenadah,corresponding author464,466 Habib Bouazzi,corresponding author468 Carlos Trujillo,469 Mohammad Khalid Alwasiyah,470,471 Mohammed Al-Qahtani,471 Maha Alotaibi,472 Rami Nassir,corresponding author473 Ishfaq A. Sheikh,corresponding author474 Mohammad A. Kamal,474 Essam H. Jiffri,475 Ghulam M. Ashraf,474 Mohd A. Beg,474 Mohammad A. Aziz,corresponding author476 Rizwan Ali,476 Mahmood Rasool,477 Mohammad S. Jamal,478 Nusaibah Samman,476 Ghufrana Abdussami,479 Sathish Periyasamy,476 Mohiuddin K. Warsi,480 Mohammed Aldress,476 Majed Al Otaibi,476 Zeyad Al Yousef,476 Mohamed Boudjelal,476 Abdelbasit Buhmeida,477 Mohammed H. Al-Qahtani,477 Ibrahim AlAbdulkarim,476 Rubi Ghazala,corresponding author481 Shilu Mathew,482 M. Haroon Hamed,483 Mourad Assidi,482,484 Mohammed Al-Qahtani,482 Ishtiaq Qadri,corresponding author485 Ishfaq A. Sheikh,486 Muhammad Abu-Elmagd,487,488 Rola F. Turki,488,489 Ghazi A. Damanhouri,486 Mohd A. Beg,corresponding author486 Mohd Suhail,490 Abid Qureshi,491 Adil Jamal,492 Peter Natesan Pushparaj,493 Mohammad Al-Qahtani,493 Ishtiaq Qadri,corresponding author490 Mahmoud Z. El-Readi,corresponding author494,495 Safaa Y. Eid,494,496 Michael Wink,496 Ahmed M. Isa,corresponding author497 Lulu Alnuaim,497 Johara Almutawa,497 Basim Abu-Rafae,497 Saleh Alasiri,497 Saleh Binsaleh,498 Nazia Nazam,499 Mohamad I. Lone,499 Waseem Ahmad,corresponding author500 Shakeel A. Ansari,500 and Mohamed H. Alqahtani500

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