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1-Methyl-2-undecylquinolin-4(1H)-one

$1,000 $900

  • Brand : BIOFRON

  • Catalogue Number : BN-B0501

  • Specification : 98%(HPLC)

  • CAS number : 59443-02-6

  • Formula : C21H31NO

  • Molecular Weight : 313.48

  • Volume : 5MG

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Catalogue Number

BN-B0501

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

313.48

Appearance

Botanical Source

Structure Type

Category

SMILES

CCCCCCCCCCCC1=CC(=O)C2=CC=CC=C2N1C

Synonyms

1-Methyl-2-undecyl-4(1H)-quinolone/1-Methyl-2-undecyl-4(1H)-quinolinone/4(1H)-Quinolinone, 1-methyl-2-undecyl-/1-methyl-2-undecyl-1H-quinolin-4-one

IUPAC Name

Applications

Density

1.0±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

141.0±18.1 °C

Boiling Point

419.9±45.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:59443-02-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

32076051

Abstract

Primary Sjogren’s syndrome (pSS) is a chronic autoimmune disease, with only palliative treatments available. Recent work has suggested that increased bone morphogenetic protein 6 (BMP6) expression could alter cell signaling in the salivary gland (SG) and result in the associated salivary hypofunction. We examined the prevalence of elevated BMP6 expression in a large cohort of pSS patients and tested the therapeutic efficacy of BMP signaling inhibitors in two pSS animal models. Increased BMP6 expression was found in the SGs of 54% of pSS patients, and this increased expression was correlated with low unstimulated whole saliva flow rate. In mouse models of SS, inhibition of BMP6 signaling reduced phosphorylation of SMAD1/5/8 in the mouse submandibular glands, and led to a recovery of SG function and a decrease in inflammatory markers in the mice. The recovery of SG function after inhibition of BMP6 signaling suggests cellular plasticity within the salivary gland and a possibility for therapeutic intervention that can reverse the loss of function in pSS.

Subject terms: Rheumatology, Rheumatic diseases

Title

Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjogren’s syndrome in mice

Author

Hongen Yin, Lovika Kalra, Zhennan Lai, Maria C. Guimaro, Lauren Aber, Blake M. Warner, Drew Michael, Nan Zhang, Javier Cabrera-Perez, Arif Karim, William D. Swaim, Sandra Afione, Alexandria Voigt, Cuong Q. Nguyen, Paul B. Yu, Donald B. Bloch, John A. Chiorini

Publish date

2020;

PMID

23666865

Abstract

Sex chromosome divergence has been documented across phylogenetically diverse species, with amphibians typically having cytologically nondiverged (“homomorphic”) sex chromosomes. With an aim of further characterizing sex chromosome divergence of an amphibian, we used “RAD-tags” and Sanger sequencing to examine sex specificity and heterozygosity in the Western clawed frog Silurana tropicalis (also known as Xenopus tropicalis). Our findings based on approximately 20 million genotype calls and approximately 200 polymerase chain reaction-amplified regions across multiple male and female genomes failed to identify a substantially sized genomic region with genotypic hallmarks of sex chromosome divergence, including in regions known to be tightly linked to the sex-determining region. We also found that expression and molecular evolution of genes linked to the sex-determining region did not differ substantially from genes in other parts of the genome. This suggests that the pseudoautosomal region, where recombination occurs, comprises a large portion of the sex chromosomes of S. tropicalis. These results may in part explain why African clawed frogs have such a high incidence of polyploidization, shed light on why amphibians have a high rate of sex chromosome turnover, and raise questions about why homomorphic sex chromosomes are so prevalent in amphibians.

KEYWORDS

sex chromosome, pseudoautosomal region, recombination, sex determination, African clawed frogs, Xenopus tropicalis

Title

A Large Pseudoautosomal Region on the Sex Chromosomes of the Frog Silurana tropicalis

Author

Adam J. Bewick, Frederic J.J. Chain, Lyle B. Zimmerman, Abdul Sesay, Michael J. Gilchrist, Nick D.L. Owens, Eva Seifertova, Vladimir Krylov, Jaroslav Macha, Tereza Tlapakova, Svatava Kubickova, Halina Cernohorska, Vojtech Zarsky, Ben J. Evans

Publish date

2013

PMID

28775854

Abstract

The solvated title compound, [ZnCl2(C20H17BrN2)]·0.5CH2Cl2, comprises a bidentate imino­pyridine ligand and two Cl atoms bound to a zinc2+ cation in a distorted tetra­hedral arrangement. The chelate bond lengths are consistent with localized C=N double bonds and a C—C single bond, as expected for an unreduced ligand bound to a closed-shell transition metal cation. Apart from weak nonclassical C—H⋯Cl hydrogen bonds between the complex mol­ecules and the disordered solvent mol­ecules (occupancy = 0.5), no further significant inter­molecular inter­actions are observed.

KEYWORDS

crystal structure, imino­pyridine, redox-active ligand, coordination compound, zinc(II), pyridyl halide

Title

Crystal structure of {N-[(6-bromo­pyridin-2-yl)(phen­yl)methyl­idene]-2,6-di­methyl­aniline-κ2N,N′}di­chlorido­zinc di­chloro­methane hemisolvate

Author

Bradley M. Wile

Publish date

2017 Jul 1