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The potential use of a novel scaffold biomaterial consisting of crosslinked hyaluronic acid (HA)-gelatin (Ge) composite microgels was investigated for use in treating vocal fold injury and scarring. Cell adhesion integrins and kinematics of cell motion were investigated in two- and three-dimensional culture conditions, respectively. Human vocal fold fibroblast (hVFF) cells were seeded on HA-Ge microgels attached to a HA hydrogel thin film. The results showed that hVFF cells established effective adhesion to HA-Ge microgels through the ubiquitous expression of β1 integrin in the cell membrane. The microgels were then encapsulated in a three-dimensional HA hydrogel for the study of cell migration. The cells within the HA-Ge microgel-reinforced composite hydrogel (MRCH) scaffold had an average motility speed of 0.24±0.08 μm/minute. The recorded microscopic images revealed features that are presumably associated with lobopodial and lamellipodial cell migration modes within the MRCH scaffold. Average cell speed during lobopodial migration was greater than that during lamellipodial migration. The cells moved faster in the MRCH than in the HA-Ge gel without microgels. These findings support the hypothesis that HA-Ge MRCH promote cell adhesion and migration; thereby they constitute a promising biomaterial for vocal fold repair.
cell adhesion/spreading, cell migration mechanisms, hyaluronic acid/gelatin hydrogel, vocal fold repair
Investigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic acid/Gelatin Microgel-Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration
Hossein K. Heris, Jamal Daoud, Sara Sheibani, Hojatollah Vali, Maryam Tabrizian, Luc Mongeau
2017 Jan 21.
4′,6-Dioarboxyamide-2-phenyl indole (DCI), a non-ionic structural analogue of 4′,6-diamidine-2-phenyl indole·2HCl (DAPI), was synthesized in order to verify the hypothesis of intercalation of both dyes into the DNA double helix.
The influence of pH, viscosity, and different concentrations of SDS (sodium dodecylsulphate) or NaCl on the optical and fluorescent properties and the changes in thermal transition of both dye complexes with DNA confirm the affinity of the dyes to the double helix as well as their stabilizing influence on the secondary DNA structure.
The results of binding studies, carried out by fluorescent methods have shown that the dyes are strongly bound to DNA, though the number of binding sites is small. According to the experimental data, the fluorescent properties of DAPI and DCI complexes with DNA are connected with the intercalating binding mechanism of these dyes. On the other hand, the eventual ionic or hydrogen bonds of dyes outside the DNA helix do not change noticeably their fluorescent properties.
Fluorescent complexes of DNA with DAPI 4′,6-diamidine-2-phenyl indole.2HCl or DCI 4′,6-dicarboxyamide-2-phenyl indole
Jan Kapuściński, Bogna Skoczylas
Oncocytes were found in the bronchial glands of 30 of 33 lungs in which the left bronchial tree was examined. They were found with similar frequency in the main, upper and lower lobe bronchi. They were found more commonly with increasing age and were most frequent in the collecting duct of the bronchial glands. However, they were absent from the collecting duct in 14 cases. They were not increased in chronic bronchitics. It is unlikely that bronchial oncocytes have a specific function in bronchial gland ducts but they may represent a curious form of degeneration of epithelial cells as do oncocytes in other organs.
Oncocytes in human bronchial mucous glands
K. Matsuba, T. Takizawa, W. M. Thurlbeck