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10-hydroxycamptothecin

$192

  • Brand : BIOFRON

  • Catalogue Number : BD-P0001

  • Specification : 99.0%(HPLC)

  • CAS number : 19685-09-7

  • Formula : C20H16N2O5

  • Molecular Weight : 364.35

  • PUBCHEM ID : 97226

  • Volume : 1000mg

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Catalogue Number

BD-P0001

Analysis Method

Specification

99.0%(HPLC)

Storage

-20℃

Molecular Weight

364.35

Appearance

Powder

Botanical Source

This product is isolated and purified from the barks of Camptotheca acuminata Decne

Structure Type

Category

SMILES

CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O

Synonyms

IUPAC Name

Density

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

HAWSQZCWOQZXHI-FQEVSTJZSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:19685-09-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

No Article Available.


Description :

Int J Pharm. 2014 Apr 25;465(1-2):378-87. A novel multifunctional poly(amidoamine) dendrimeric delivery system with superior encapsulation capacity for targeted delivery of the chemotherapy drug 10-hydroxycamptothecin.[Pubmed: 24530519]With the aim of developing an efficient targeted delivery system for cancer therapy that overcomes drug leakage during circulation, we prepared a novel multifunctional dendrimeric carrier by integrating long hydrophobic C₁₂ alkyl chains, poly(ethylene glycol) chains and c(RGDfK) ligands presented on the surface. This dendrimer was able to tightly encapsulate the hydrophobic anticancer drug 10-Hydroxycamptothecin ((S)-10-Hydroxycamptothecin ,10-HCPT) through simple complexation and selectively target the drug to cancer cells overexpressing integrin αvβ₃ through high affinity interactions. The complex has a high loading efficiency, with each molecule encapsulating approximately 20 drug molecules; high stability, without any detectable drug release during dialysis for three days; and high water solubility, achieving an approximately 600-fold increase over the water solubility of free 10-Hydroxycamptothecin((S)-10-Hydroxycamptothecin ). This complex exhibited notably high cytotoxicity against 22RV1 cells overexpressing integrin αvβ₃ and a far lower cytotoxicity against MCF-7 cells, which express low levels of integrin αvβ₃. We expected encapsulated 10-Hydroxycamptothecin((S)-10-Hydroxycamptothecin ) to regain its anti-cancer activity following selective internalization of the complex into carcinoma cells via integrin receptor mediated endocytosis. As the drug remains inactive before internalization, this carrier has the ability to overcome problems associated with drug leakage in the circulation and off-target effects on normal tissues.