Shipping to United States We Offer Worldwide Shipping
Login Wishlist

1,18-Octadecanediol

$640 $576

  • Brand : BIOFRON

  • Catalogue Number : BN-O0425

  • Specification : 90%(HPLC)

  • CAS number : 3155-43-9

  • Formula : C18H38O2

  • Molecular Weight : 286.49

  • PUBCHEM ID : 520529

  • Volume : 5MG

In stock

Quantity
Checkout Bulk Order?

Catalogue Number

BN-O0425

Analysis Method

HPLC,NMR,MS

Specification

90%(HPLC)

Storage

-20℃

Molecular Weight

286.49

Appearance

Powder

Botanical Source

This product is isolated and purified from the herb of Spartium japonicum.

Structure Type

Lipids

Category

Standards;Natural Pytochemical;API

SMILES

C(CCCCCCCCCO)CCCCCCCCO

Synonyms

1,18-Octadecanediol/Octadecane-1,18-diol/Octadecamethylenglykol/1,18-Dihydroxyoctadecan/Octadecan-1,18-diol

IUPAC Name

octadecane-1,18-diol

Applications

Density

0.9±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

169.1±13.6 °C

Boiling Point

397.4±10.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

LUUFSCNUZAYHAT-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2905390000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:3155-43-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26287243

Abstract

One of the possible causes of enhanced atherosclerosis in patients with chronic kidney disease (CKD) is the accumulation of uremic toxins. Since macrophage foam cell formation is a hallmark of atherosclerosis, we examined the direct effect of indoxyl sulfate (IS), a representative uremic toxin, on macrophage function. Macrophages differentiated from THP-1 cells were exposed to IS in vitro. IS decreased the cell viability of THP-1 derived macrophages but promoted the production of inflammatory cytokines (IL-1β, IS 1.0 mM: 101.8 ± 21.8 pg/mL vs. 0 mM: 7.0 ± 0.3 pg/mL, TNF-α, IS 1.0 mM: 96.6 ± 11.0 pg/mL vs. 0 mM: 15.1 ± 3.1 pg/mL) and reactive oxygen species. IS reduced macrophage cholesterol efflux (IS 0.5 mM: 30.3% ± 7.3% vs. 0 mM: 43.5% ± 1.6%) and decreased ATP-binding cassette transporter G1 expression. However, lipid uptake into cells was not enhanced. A liver X receptor (LXR) agonist, T0901317, improved IS-induced production of inflammatory cytokines as well as reduced cholesterol efflux. In conclusion, IS induced inflammatory reactions and reduced cholesterol efflux in macrophages. Both effects of IS were improved with activation of LXR. Direct interactions of uremic toxins with macrophages may be a major cause of atherosclerosis acceleration in patients with CKD.

KEYWORDS

indoxyl sulfate, macrophage, chronic kidney disease, atherosclerosis

Title

Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate

Author

Koji Matsuo,1 Suguru Yamamoto,1,* Takuya Wakamatsu,1 Yoshimitsu Takahashi,1 Kazuko Kawamura,1 Yoshikatsu Kaneko,1 Shin Goto,1 Junichiro J. Kazama,1,2 and Ichiei Narita1

Publish date

2015 Aug;

PMID

2470092

Abstract

We report experiments that test the model that in Xenopus laevis, RNA polymerase I is “handed over” in a conservative fashion from the T3 terminator to the adjacent gene promoter. We have introduced transcription-terminating lesions into the ribosomal DNA repeat by irradiating cultured cells with ultraviolet light. We used isolated nuclei to measure the effect of such lesions on transcription. UV damage sufficient to prevent all elongating RNA polymerase from reaching T3 from upstream had no adverse effect on the density of RNA polymerase at the very 5′ end of the gene. We conclude that high rates of transcription initiation at the gene promoter do not depend upon polymerase passing from one repeat to the next or on polymerase initiating at the spacer promoters.

Title

High initiation rates at the ribosomal gene promoter do not depend upon spacer transcription.

Author

P Labhart and R H Reeder

Publish date

1989 May;