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16-Epiabbeokutone

$1,376

  • Brand : BIOFRON

  • Catalogue Number : BN-O1589

  • Specification : 98%(HPLC)

  • CAS number : 135683-73-7

  • Formula : C20H32O3

  • Molecular Weight : 320.5

  • PUBCHEM ID : 392471

  • Volume : 5mg

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Catalogue Number

BN-O1589

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

320.5

Appearance

Powder

Botanical Source

This product is isolated and purified from the herbs of Croton laevigatus

Structure Type

Diterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C2CCC34CC(CCC3C2(CCC1=O)C)C(C4)(CO)O)C

Synonyms

(5β,8α,9β,10α,13α)-16,17-Dihydroxykauran-3-one

IUPAC Name

(1S,4S,9S,10R,13R,14S)-14-hydroxy-14-(hydroxymethyl)-5,5,9-trimethyltetracyclo[11.2.1.01,10.04,9]hexadecan-6-one

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

246.1±23.8 °C

Boiling Point

460.0±40.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C20H32O3/c1-17(2)14-6-9-19-10-13(20(23,11-19)12-21)4-5-15(19)18(14,3)8-7-16(17)22/h13-15,21,23H,4-12H2,1-3H3/t13-,14-,15+,18-,19+,20-/m1/s1

InChl Key

MPDUJZZNNBJFAB-XYYNDNLRSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:135683-73-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28935860

Abstract

Childhood and adolescent overweight and obesity are increasing in China, but limited information is available on its secular trends in Guangzhou. In this cross-sectional study, ten-wave successive data were obtained from the physical fitness surveillance for students in Guangzhou from 2003 to 2012. A total of 2,619,154 urban students aged 7-18 years were included. The age-standardized prevalence of overweight and obesity increased significantly over the period: overweight rose from 10.15% to 14.07% in boys and 6.39% to 8.11% in girls, while obesity increased from 5.65% to 8.31% for boys and 3.43% to 4.12% for girls, respectively (P < 0.05). The increasing trend was significant across almost all age-sex-specific groups (P < 0.05), especially in the last five years. The prevalence of overweight and obesity grew continuously in both sexes, but the pace of change for boys were faster than that for girls. The highest prevalence of overweight was found among 10- to 12-year-old boys, that of obesity among 7- to 9-year-old boys and girls. In conclusion, overweight and obesity have increased significantly among urban children and adolescents in Guangzhou during 2003-2012. Further analysis of influencing factors and comprehensive interventions are urgently needed to combat the obesity epidemic among urban children and adolescents in Guangzhou.

Title

Secular trends in overweight and obesity among urban children and adolescents, 2003-2012: A serial cross-sectional study in Guangzhou, China

Author

Yinan Zong,#1 Runsheng Xie,#1 Nali Deng,2 Li Liu,1 Weiqing Tan,2 Yanhui Gao,1 Jiewen Yang,corresponding author2 and Yi Yangcorresponding author1

Publish date

2017

PMID

28873440

Abstract

Background
Fluoroquinolone is a commonly prescribed antimicrobial agent, and up to 20% of its users registers adverse gastroenterological symptoms. We aimed to evaluate the association between use of fluoroquinolone and gastrointestinal tract perforation.

Methods
We conducted a nested case-control study on a national health insurance claims database between 1998 and 2011. The use of fluoroquinolones was classified into current (< 60 days), past (61-365 days prior to the index date) and any prior year use of fluoroquinolones. We used the conditional logistic regression model to estimate rate ratios (RRs), adjusting or matching by a disease risk score (DRS). Results We identified a cohort of 17,510 individuals diagnosed with gastrointestinal perforation and matched them to 1,751,000 controls. Current use of fluoroquinolone was associated with the greatest increase in risk of gastrointestinal perforations after DRS score adjustment (RR, 1.90; 95% CI, 1.62-2.22). The risk of gastrointestinal perforation was attenuated for past (RR, 1.33; 95% CI, 1.20-1.47) and any prior year use (RR, 1.46; 95% CI, 1.34-1.59). To gain insights into whether the observed association can be explained by unmeasured confounder, we compared the risk of gastrointestinal perforation between fluoroquinolone and macrolide. Use of macrolide, an active comparator, was not associated with a significant increased risk of gastrointestinal perforation (RR, 1.11, 95%CI, 0.15-7.99). Sensitivity analysis focusing on perforation requiring in-hospital procedures also demonstrated an increased risk associated with current use. To mitigate selection bias, we have also excluded people who have never used fluoroquinolone before or people with infectious colitis, enteritis or gastroenteritis. In both of the analysis, a higher risk of gastrointestinal perforation was still associated with the use of fluoroquinolone. Conclusions We found that use of fluoroquinolones was associated with a non-negligible increased risk of gastrointestinal perforation, and physicians should be aware of this possible association.

Title

Risk of gastrointestinal perforation in patients taking oral fluoroquinolone therapy: An analysis of nationally representative cohort

Author

Shou-Chien Hsu, Formal analysis, Resources, Writing - original draft,1 Shy-Shin Chang, Conceptualization, Writing - original draft,2 Meng-tse Gabriel Lee, Writing - original draft,3 Si-Huei Lee, Methodology,4,5 Yi-Wen Tsai, Methodology,6 Shen-Che Lin, Supervision, Validation,1 Szu-Ta Chen, Writing - review & editing,7,8,9 Yi-Chieh Weng, Formal analysis,3 Lorenzo Porta, Writing - review & editing,10 Jiunn-Yih Wu, Conceptualization, Methodology, Resources, Writing - review & editing,1,* and Chien-Chang Lee, Conceptualization, Funding acquisition, Supervision, Validation, Writing - review & editing3,*

Publish date

2017;

PMID

23118869

Abstract

Aim
Investigate the cost and effects of a single-pill versus two- or three pill first-line antiretroviral combinations in reducing viral load, increasing CD4 counts, and first-line failure rate associated with respective regimens at 6 and 12 months.

Methods
Patients on first-line TDF+3TC+EFV, TDF+FTC+EFV, Truvada®+EFV or Atripla® between 1996-2008 were identified and viral load and CD4 counts measured at baseline, six and twelve months respectively. Factors that independently predicted treatment failure at six and twelve months were derived using multivariate Cox’s proportional hazard regression analyses. Use and cost of hospital services were calculated at six and twelve months respectively.

Results
All regimens reduced viral load to below the limit of detection and CD4 counts increased to similar levels at six and twelve months for all treatment regimens. No statistically significant differences were observed for rate of treatment failure at six and twelve months. People on Atripla® generated lower healthcare costs for non-AIDS patients at £5,340 (£5,254 to £5,426) per patient-semester and £9,821 (£9,719 to £9,924) per patient-year that was £1,344 (95%CI £1,222 to £1,465) less per patient-semester and £1,954 (95%CI £1,801 to £2,107) less per patient-year compared with Truvada®+EFV; healthcare costs for AIDS patients were similar across all regimens.

Conclusion
The single pill regimen is as effective as the two- and three-pill regimens of the same drugs, but if started as first-line induction therapy there would be a 20% savings on healthcare costs at six and 17% of costs at twelve months compared with Truvada®+EFV, that generated the next lowest costs.

Title

Lower Healthcare Costs Associated with the Use of a Single-Pill ARV Regimen in the UK, 2004-2008

Author

Eduard J. Beck, 1 , 2 , 7 , * Sundhiya Mandalia, 1 , 3 , 7 Roshni Sangha, 1 Mike Youle, 1 , 4 Ray Brettle, 5 Mark Gompels, 6 Margaret Johnson, 4 Anton Pozniak, 7 Achim Schwenk, 8 Stephen Taylor, 9 John Walsh, 10 Ed Wilkins, 11 Ian Williams, 12 Brian Gazzard, 1 , 3 , 7 and , for the NPMS-HHC Steering Group Maarten Postma, Editor

Publish date

2012


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