White crystalline powder
(3β)-3-Hydroxy-11-oxoolean-12-en-30-oic acid/Glycyrrhetinic acid/(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-Hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydro-2-picenecarboxylic acid/18-beta-Glycyrrhetinic acid/Arthrodont/18-β-Glycyrrhetinic Acid/glycyrrhetin/GM 1658/Uralenic acid/3β-Hydroxy-11-oxoolean-12-en-30-oic acid/18b-Glycyrrhetic acid/Biosone/Olean-12-en-30-oic acid, 3β-hydroxy-11-oxo-/18β-Glycyrrhetinic acid/STX 352/Glycyrrhetic Acid/PO 12/Olean-12-en-30-oic acid, 3-hydroxy-11-oxo-, (3β)-/3b-Hydroxy-11-oxoolean-12-en-30-oic Acid/18b-Glycyrrhetinic Acid/Glycyrrhetinate/(3b,20b)-3-Hydroxy-11-oxoolean-12-en-29-oic Acid/ENOLOXONE/enoxolone
Methanol; Water; DMSO
588.3±50.0 °C at 760 mmHg
292 - 295ºC
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:471-53-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
[Effect of glycyrrhetinic acid on apoptosis of thyroid cancer cell line SW579 and its mechanism].
Li FY, Chen YG, Lin DY, Bai J.
Accumulating evidence suggests that aberrant DNA methylation and gene silencing of tumor suppressors are pervasive in gastric malignancies, supporting reactivation of tumor suppressors through DNA demethylation as a potential therapeutic opportunity. Atp4a is an important tumor suppressor gene, encoding H+, K+-ATPase, and mediating gastric acid secretion in the stomach. Using transgenic gastric cancer model K19-Wnt1/C2mE (Gan) mice, by combining the transcriptome and MeDIP (methylated DNA immunoprecipitation) sequencing, together with qRT-PCR, we showed that Atp4a was expressed at low levels in tumor tissues and multiple GC cells, while both 5-aza-CdR and 18β-glycyrrhetinic acid (GRA) pharmacological treatment triggered Atp4a activation with downregulation of DNMT1. In addition, CpG island (CGI) search showed that the CpG rich region is absent in the promoter region but present in exons 9-14 of Atp4a. Methylation specific PCR (MSP) indicated that Atp4a was fully or partly methylated in multiple GC cells. Further MassArray suggested that the demethylation in the CpG site 75, 183, 196, 262-268 might be responsible for the reactivation of Atp4a. Our research identified that GRA, a bioactive component found in abundance in Radix Glycyrrhiza, reactivated Atp4a expression and inhibited gastric tumorigenesis as a potential demethylation agent.
Copyright © 2019. Published by Elsevier Inc.
18β-glycyrrhetinic acid; Atp4a; DNA methylation; Gastric cancer
Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model.
Cao D1, Zhao D1, Jia Z1, Su T2, Zhang Y1, Wu Y1, Wu M2, Tsukamoto T3, Oshima M4, Jiang J1, Cao X5.
2020 Feb 1
Semisynthetic 18β-glycyrrhetinic acid (GA) analogues bearing 1-en-2-cyano-3-oxo substitution on ring A have enhanced antitumor effects with reduced levels of HDAC3 and HDAC6 proteins. Aiming to inhibit both HDAC protein and activity, we developed a hybrid molecule by tethering active GA analogue methyl 2-cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate (CDODA-Me) and Vorinostat (SAHA). We tested the proper hybrid approaches of GA with hydroxamic acid and turned out that GA conjugated with SAHA by a piperazine linker was the best. The conjugate (15) of CDODA-Me and SAHA linked through a piperazine group was a potent cytotoxic agent against cancer cells with apoptosis induction. Compound 15 was more effective than the simple combination of CDODA-Me and SAHA to induce apoptosis. Mechanistic studies revealed that 15 was less effective than SAHA to inhibit HDAC activity, but was more effective than CDODA-Me to decrease the levels of HDAC3 and HDAC6 proteins with upregulated levels of acetylated H3 and acetylated α-tubulin. Compound 15 represents a new HDAC3 and HDAC6 inhibitor by reducing protein levels.
Copyright © 2019. Published by Elsevier Masson SAS.
18β-glycyrrhetinic acid; Anticancer; Conjugate; HDAC
A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects.
Huang M1, Xie X2, Gong P2, Wei Y1, Du H1, Xu Y1, Xu Q1, Jing Y3, Zhao L4.
2020 Feb 15
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.