(1S,2R)-1-Aminoindan-2-ol/1H-Inden-2-ol, 1-amino-2,3-dihydro-, (1S,2R)-/(1S,2R)-(-)-1-A/3aR/(1S,2R)-(−)-cis-1-Amino-2-hydroxyindane/(1S,2R)-(-)-cis-1-Amino-2,3-dihydro-1H-inden-2-ol/4292559/(1S,2R)-(−)-cis-1-Amino-2-indanol/cis-aminoindanol/(1S,2R)-1-Amino-2-indanol/cis-(1S,2R)-1-Amino-2-indanol/(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol/(1S,2R)-(-)-1-Amino-2-hydroxyindan/L56T&J BZ CQ &&(1S,2R)- Form/(1S,2R)-(-)-cis-1-Amino-2-indanol
290.0±40.0 °C at 760 mmHg
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We added spleen cells from adult BALB/c mice treated with total lymphoid irradiation (TLI) to the mixed leukocyte reaction (MLR) using a variety of responder and stimulator cells. The spleen cells nonspecifically suppressed the uptake of [3H]-thymidine and the generation of cytolytic cells regardless of the responder-stimulator combination used. We also examined the effect of the spleen cells on the generation of antigen-nonspecific and antigen-specific suppressor cells in the MLR. The experimental results suggest that the spleen cells from TLI-treated mice inhibit the generation of nonspecific suppressor cells, but do not inhibit the generation of antigen-specific suppressor cells. Thus, alloantigenic stimulation of normal responder cells in vitro in the presence of spleen cells from TLI-treated mice generates large numbers of antigen-specific suppressor cells, but few cytolytic cells or nonspecific suppressor cells. Similar nonspecific inhibition of the MLR was observed with neonatal spleen cells. This in vitro system provides a regulatory model for the induction and maintenance of tolerance in vivo, in which adult mice given TLI or neonatal mice accept allogeneic bone marrow transplants without graft- vs.-host disease.
Spleen cells from adult mice given total lymphoid irradiation or from newborn mice have similar regulatory effects in the mixed leukocyte reaction. I. Generation of antigen-specific suppressor cells in the mixed leukocyte reaction after the addition of spleen cells from adult mice given total lymphoid irradiation
1982 Aug 1;