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2,2,5,5-Tetramethylcyclohexane-1,4-dione

$640

  • Brand : BIOFRON

  • Catalogue Number : BN-O1568

  • Specification : 98%(HPLC)

  • CAS number : 86838-54-2

  • Formula : C10H16O2

  • Molecular Weight : 168.2

  • PUBCHEM ID : 13390715

  • Volume : 5mg

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Catalogue Number

BN-O1568

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

168.2

Appearance

Powder

Botanical Source

This product is isolated and purified from the herbs of Liriodendron tulipifera

Structure Type

Monoterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(CC(=O)C(CC1=O)(C)C)C

Synonyms

W1923/1,4-Cyclohexanedione, 2,2,5,5-tetramethyl-/Tetramethyl-2,2,5,5-cyclohexanedione-1,4/2,2,5,5-Tetramethyl-1,4-cyclohexanedione/2,2,5,5-tetramethyl 1,4-cyclohexanedione/1,4-Cyclohexanedione,2,2,5,5-tetramethyl/2,2,5,5-tetramethyl-cyclohexane-1,4-dione

IUPAC Name

2,2,5,5-tetramethylcyclohexane-1,4-dione

Density

1.0±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

88.1±22.4 °C

Boiling Point

240.8±33.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

OTQZSPVHJYLKOL-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2914290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:86838-54-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

21092232

Abstract

Background
The Fagaceae family comprises about 1,000 woody species worldwide. About half belong to the Quercus family. These oaks are often a source of raw material for biomass wood and fiber. Pedunculate and sessile oaks, are among the most important deciduous forest tree species in Europe. Despite their ecological and economical importance, very few genomic resources have yet been generated for these species. Here, we describe the development of an EST catalogue that will support ecosystem genomics studies, where geneticists, ecophysiologists, molecular biologists and ecologists join their efforts for understanding, monitoring and predicting functional genetic diversity.

Results
We generated 145,827 sequence reads from 20 cDNA libraries using the Sanger method. Unexploitable chromatograms and quality checking lead us to eliminate 19,941 sequences. Finally a total of 125,925 ESTs were retained from 111,361 cDNA clones. Pyrosequencing was also conducted for 14 libraries, generating 1,948,579 reads, from which 370,566 sequences (19.0%) were eliminated, resulting in 1,578,192 sequences. Following clustering and assembly using TGICL pipeline, 1,704,117 EST sequences collapsed into 69,154 tentative contigs and 153,517 singletons, providing 222,671 non-redundant sequences (including alternative transcripts). We also assembled the sequences using MIRA and PartiGene software and compared the three unigene sets. Gene ontology annotation was then assigned to 29,303 unigene elements. Blast search against the SWISS-PROT database revealed putative homologs for 32,810 (14.7%) unigene elements, but more extensive search with Pfam, Refseq_protein, Refseq_RNA and eight gene indices revealed homology for 67.4% of them. The EST catalogue was examined for putative homologs of candidate genes involved in bud phenology, cuticle formation, phenylpropanoids biosynthesis and cell wall formation. Our results suggest a good coverage of genes involved in these traits. Comparative orthologous sequences (COS) with other plant gene models were identified and allow to unravel the oak paleo-history. Simple sequence repeats (SSRs) and single nucleotide polymorphisms (SNPs) were searched, resulting in 52,834 SSRs and 36,411 SNPs. All of these are available through the Oak Contig Browser http://genotoul-contigbrowser.toulouse.inra.fr:9092/Quercus_robur/index.html.

Conclusions
This genomic resource provides a unique tool to discover genes of interest, study the oak transcriptome, and develop new markers to investigate functional diversity in natural populations.

Title

Bioinformatic analysis of ESTs collected by Sanger and pyrosequencing methods for a keystone forest tree species: oak

Author

Saneyoshi Ueno,1,2 Gregoire Le Provost,1 Valerie Leger,1 Christophe Klopp,3 Celine Noirot,3 Jean-Marc Frigerio,1 Franck Salin,1 Jerôme Salse,4 Michael Abrouk,4 Florent Murat,4 Oliver Brendel,5 Jeremy Derory,1 Pierre Abadie,1 Patrick Leger,1 Cyril Cabane,6,7 Aurelien Barre,6 Antoine de Daruvar,6,7 Arnaud Couloux,8 Patrick Wincker,8 Marie-Pierre Reviron,1 Antoine Kremer,1 and Christophe Plomioncorresponding author1

Publish date

2010;

PMID

31853424

Abstract

Purpose
To systematically evaluate human rod opsin (hRHO) mRNA for potential target sites sensitive to posttranscriptional gene silencing (PTGS) by hammerhead ribozyme (hhRz) or RNA interference (RNAi) in human cells. To develop a comprehensive strategy to identify and optimize lead candidate agents for PTGS gene therapeutics.

Methods
In multidisciplinary RNA drug discovery, computational mRNA accessibility and in vitro experimental methods using reverse transcription-polymerase chain reaction (RT-PCR) were used to map accessibility in full-length hRHO transcripts. HhRzs targeted predicted accessible and inaccessible sites and were screened for cellular knockdown using a bicistronic reporter construct. Lead hhRz and RNAi PTGS agents were rationally optimized for target knockdown in human cells.

Results
Systematic screening of hRHO mRNA targeting agents resulted in lead candidate identification of a novel hhRz embedded in an RNA scaffold. Rational optimization strategies identified a minimal 725 hhRz as the most active agent. Recently identified tertiary accessory elements did not enhance activity. A 725-short-hairpin RNA (shRNA) agent exerts log-order knockdown. Silent modulation of the 725-hhRz target site in hRHO mRNA resulted in resistance to knockdown.

Conclusions
Combining rational RNA drug design with cell-based screening allowed rapid identification of lead agents targeting hRHO. Optimization strategies identified the agent with highest intracellular activity. These agents have therapeutic potential in a mutation-independent strategy for adRP, or other degenerations where hRHO is a target. This approach can be broadly applied to any validated target mRNA, regardless of the disease.

Translational Relevance
This work establishes a platform approach to develop RNA biologicals for the treatment of human disease.

KEYWORDS

retinal degeneration, macular degeneration, gene therapy, high throughput screening, ribozyme, siRNA, shRNA, DNAzyme

Title

Systematic Screening, Rational Development, and Initial Optimization of Efficacious RNA Silencing Agents for Human Rod Opsin Therapeutics

Author

Edwin H. Yau,1,2,* Robert T. Taggart,2 Mohammed Zuber,3,† Alexandria J. Trujillo,1,2 Zahra S. Fayazi,2 Mark C. Butler,2,3,‡ Lowell G. Sheflin,1 Jennifer B. Breen,2,§ Dian Yu,2,¶ and Jack M. Sullivancorresponding author17

Publish date

2019 Nov

PMID

27746925

Abstract

A new polymorph of the title compound, [Re(NCS)(C7H8N2O)(CO)3], crystallizing in the space group P21/n, has been obtained and structurally characterized by the experiment and DFT calculations. In this complex, the rhenium(I) cation is octa­hedrally coordinated by three carbonyl groups in a facial configuration, the N,O-bidentate N-methyl­pyridine-2-carboxamide ligand and the N-bonded thio­cyanate anion. Neighbouring mol­ecules are linked into a three-dimensional network by inter­molecular N—H⋯S and C—H⋯S inter­actions.

KEYWORDS

crystal structure, tri­carbonyl­rhenium(I) complex, N-methylpyridine-2-carb­oxy­amide ligand, thio­cyanate ion, polymorphism

Title

Crystal structure of a second polymorph of tricarbon­yl(N-methyl­pyridine-2-carboxamide-κ2 N 1,O)(thio­cyanato-κN)rhenium(I)

Author

Krzysztof Lyczkoa,*

Publish date

2016 Oct 1;


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