Catalogue Number
BN-O1552
Analysis Method
HPLC,NMR,MS
Specification
98%(HPLC)
Storage
-20℃
Molecular Weight
226.2
Appearance
Yellow powder
Botanical Source
This product is isolated and purified from the barks of Ailanthus altissima
Structure Type
Quinones
Category
Standards;Natural Pytochemical;API
SMILES
CC(=O)CC1(C(=CC(=O)C=C1OC)OC)O
Synonyms
4-acetonyl-4-hydroxy-3,5-dimethoxy-cyclohexa-2,5-dienone/4-Hydroxy-3,5-dimethoxy-4-(2-oxopropyl)-2,5-cyclohexadien-1-one/1-Acetonyl-2,6-dimethoxy-chinol/2,6-dimethoxy-1-acetonylquinol/4-Acetonyl-4-hydroxy-3,5-dimethoxy-cyclohexa-2,5-dienon/3,5-Dimethoxy-4-acetonyl-p-chinol/2,5-Cyclohexadien-1-one, 4-hydroxy-3,5-dimethoxy-4-(2-oxopropyl)-/4-acetonyl-3,5-dimethoxy-p-quinol
IUPAC Name
4-hydroxy-3,5-dimethoxy-4-(2-oxopropyl)cyclohexa-2,5-dien-1-one
Density
1.2±0.1 g/cm3
Solubility
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Flash Point
181.1±22.2 °C
Boiling Point
457.5±45.0 °C at 760 mmHg
Melting Point
InChl
InChl Key
KMNCHTPRXWQOIZ-UHFFFAOYSA-N
WGK Germany
RID/ADR
HS Code Reference
2914500000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:2215-96-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
23821350
Purpose
Magnetic resonance imaging (MRI)-based techniques for assessing liver iron concentration (LIC) have been limited by single scanner calibration against biopsy. Here, the calibration of spin-density projection-assisted (SDPA) R2-MRI (FerriScan®) in iron-overloaded β-thalassemia patients treated with the iron chelator, deferasirox, for 12 months is validated.
Methods
SDPA R2-MRI measurements and percutaneous needle liver biopsy samples were obtained from a subgroup of patients (n = 233) from the ESCALATOR trial. Five different makes and models of scanner were used in the study.
Results
LIC, derived from mean of MRI- and biopsy-derived values, ranged from 0.7 to 50.1 mg Fe/g dry weight. Mean fractional differences between SDPA R2-MRI- and biopsy-measured LIC were not significantly different from zero. They were also not significantly different from zero when categorized for each of the Ishak stages of fibrosis and grades of necroinflammation, for subjects aged 3 to <8 versus ≥8 years, or for each scanner model. Upper and lower 95% limits of agreement between SDPA R2-MRI and biopsy LIC measurements were 74 and −71%.
Conclusion
The calibration curve appears independent of scanner type, patient age, stage of liver fibrosis, grade of necroinflammation, and use of deferasirox chelation therapy, confirming the clinical usefulness of SDPA R2-MRI for monitoring iron overload. Magn Reson Med 71:2215-2223, 2014. © 2013 Wiley Periodicals, Inc.
deferasirox, iron overload, β-thalassemia, ESCALATOR, biopsy
Multicenter Validation of Spin-Density Projection-Assisted R2-MRI for the Noninvasive Measurement of Liver Iron Concentration
Tim G St Pierre,* Amal El-Beshlawy, Mohsen Elalfy, Abdullah Al Jefri, Kusai Al Zir, Shahina Daar, Dany Habr, Ulrike Kriemler-Krahn, and Ali Taher
2014 Jan
29807017
Carotid body glomus cells mediate essential reflex responses to arterial blood hypoxia. They are dopaminergic and secrete growth factors that support dopaminergic neurons, making the carotid body a potential source of patient-specific cells for Parkinson’s disease therapy. Like adrenal chromaffin cells, which are also hypoxia-sensitive, glomus cells are neural crest-derived and require the transcription factors Ascl1 and Phox2b; otherwise, their development is little understood at the molecular level. Here, analysis in chicken and mouse reveals further striking molecular parallels, though also some differences, between glomus and adrenal chromaffin cell development. Moreover, histology has long suggested that glomus cell precursors are ‘emigres’ from neighbouring ganglia/nerves, while multipotent nerve-associated glial cells are now known to make a significant contribution to the adrenal chromaffin cell population in the mouse. We present conditional genetic lineage-tracing data from mice supporting the hypothesis that progenitors expressing the glial marker proteolipid protein 1, presumably located in adjacent ganglia/nerves, also contribute to glomus cells. Finally, we resolve a paradox for the ‘emigre’ hypothesis in the chicken – where the nearest ganglion to the carotid body is the nodose, in which the satellite glia are neural crest-derived, but the neurons are almost entirely placode-derived – by fate-mapping putative nodose neuronal ’emigres’ to the neural crest.
Carotid body glomus cells, Adrenal chromaffin cells, Neural crest, Schwann cell precursors, Nodose neurons
Striking parallels between carotid body glomus cell and adrenal chromaffin cell development
Dorit Hockman,a,b,c,1 Igor Adameyko,d,e Marketa Kaucka,d Perrine Barraud,a Tomoki Otani,a Adam Hunt,a Anna C. Hartwig,f Elisabeth Sock,f Dominic Waithe,g Marina C.M. Franck,h,2 Patrik Ernfors,h Sean Ehinger,i,3 Marthe J. Howard,i Naoko Brown,j Jeffrey Reese,j and Clare V.H. Bakera,⁎
2018 Dec 1;
10999861
The association of maternal smoking and type of feeding with colic was assessed in 3345 children aged 1-6 months (96% response). The prevalence of colic was twofold higher among infants of smoking mothers, but less among breastfed infants. Maternal smoking as a potential risk factor for infantile crying needs further study.
Infantile colic: maternal smoking as potential risk factor
S. Reijneveld, E. Brugman, and R. Hirasing
2000 Oct;
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