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  • Brand : BIOFRON

  • Catalogue Number : BN-O1555

  • Specification : 98%(HPLC)

  • CAS number : 154801-30-6

  • Formula : C42H85NO5

  • Molecular Weight : 684.1

  • PUBCHEM ID : 25203220

  • Volume : 5mg

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Catalogue Number


Analysis Method






Molecular Weight




Botanical Source

This product is isolated and purified from the fruits of Evodia rutaecarpa

Structure Type



Standards;Natural Pytochemical;API




Tetracosanamide, N-[2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-2-hydroxy-/2-Hydroxy-N-(1,3,4-trihydroxy-2-octadecanyl)tetracosanamide




1.0±0.1 g/cm3


Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

437.2±32.9 °C

Boiling Point

799.3±60.0 °C at 760 mmHg

Melting Point


InChl Key


WGK Germany


HS Code Reference


Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:154801-30-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




Gas vesicles are a unique class of gas-filled protein nanostructures whose physical properties allow them to serve as highly sensitive imaging agents for ultrasound and magnetic resonance imaging (MRI), detectable at sub-nanomolar concentrations. Here we provide a protocol for isolating gas vesicles from native and heterologous host organisms, functionalizing these nanostructures with moieties for targeting and fluorescence, characterizing their biophysical properties and imaging them using ultrasound and magnetic resonance imaging. Gas vesicles can be isolated from natural cyanobacterial and haloarchaeal host organisms or from E. coli expressing a heterologous gas vesicle gene cluster, and purified using buoyancy-assisted techniques. They can then be modified by replacing surface-bound proteins with engineered, heterologously expressed variants, or through chemical conjugation, resulting in altered mechanical, surface and targeting properties. Pressurized absorbance spectroscopy is used to characterize their mechanical properties, while dynamic light scattering and transmission electron microscopy are used to determine nanoparticle size and morphology, respectively. Gas vesicles can then be imaged with ultrasound in vitro and in vivo using pulse sequences optimized for their detection versus background. They can also be imaged with hyperpolarized xenon MRI using chemical exchange saturation transfer between gas vesicle-bound and dissolved xenon – a technique currently implemented in vitro. Taking 3-8 days to prepare, these genetically encodable nanostructures enable multi-modal, noninvasive biological imaging with high sensitivity and potential for molecular targeting.


Gas vesicles, protein nanostructures, noninvasive imaging, contrast agents, molecular reporters, ultrasound, hyperpolarized MRI, magnetic resonance imaging, acoustics


Preparation and Noninvasive Imaging of Biogenic Gas Vesicle Nanostructures


Anupama Lakshmanan,#1 George J. Lu,#2 Arash Farhadi,#1 Suchita P. Nety,#2 Martin Kunth,3 Audrey Lee-Gosselin,2 David Maresca,2 Raymond W. Bourdeau,2 Melissa Yin,4 Judy Yan,4 Christopher Witte,3 Dina Malounda,2 F. Stuart Foster,4,5 Leif Schroder,3 and Mikhail G. Shapiro2,*

Publish date

2018 Oct 13.




Previous studies of the association between parity and long-term cognitive changes have primarily focused on women and have shown conflicting results. We investigated this association by analyzing data collected on 303,196 subjects from the UK Biobank. We found that in both females and males, having offspring was associated with a faster response time and fewer mistakes made in the visual memory task. Subjects with two or three children had the largest differences relative to those who were childless, with greater effects observed in men. We further analyzed the association between parity and relative brain age (n = 13,584), a brain image-based biomarker indicating how old one’s brain structure appears relative to peers. We found that in both sexes, subjects with two or three offspring had significantly reduced brain age compared to those without offspring, corroborating our cognitive function results. Our findings suggest that lifestyle factors accompanying having offspring, rather than the physical process of pregnancy experienced only by females, contribute to these associations and underscore the importance of studying such factors, particularly in the context of sex.

Subject terms: Cognitive ageing, Computational neuroscience


Parity is associated with cognitive function and brain age in both females and males


Kaida Ning,1,2 Lu Zhao,1 Meredith Franklin,3 Will Matloff,1,4 Ishaan Batta,1 Nibal Arzouni,1,2 Fengzhu Sun,2 and Arthur W. Togacorresponding author1

Publish date





Human herpesvirus 6 variants A and B (HHV-6A and HHV-6B) are closely related viruses that can be readily distinguished by comparison of restriction endonuclease profiles and nucleotide sequences. The viruses are similar with respect to genomic and genetic organization, and their genomes cross-hybridize extensively, but they differ in biological and epidemiologic features. Differences include infectivity of T-cell lines, patterns of reactivity with monoclonal antibodies, and disease associations. Here we report the complete genome sequence of HHV-6B strain Z29 [HHV-6B(Z29)], describe its genetic content, and present an analysis of the relationships between HHV-6A and HHV-6B. As sequenced, the HHV-6B(Z29) genome is 162,114 bp long and is composed of a 144,528-bp unique segment (U) bracketed by 8,793-bp direct repeats (DR). The genomic sequence allows prediction of a total of 119 unique open reading frames (ORFs), 9 of which are present only in HHV-6B. Splicing is predicted in 11 genes, resulting in the 119 ORFs composing 97 unique genes. The overall nucleotide sequence identity between HHV-6A and HHV-6B is 90%. The most divergent regions are DR and the right end of U, spanning ORFs U86 to U100. These regions have 85 and 72% nucleotide sequence identity, respectively. The amino acid sequences of 13 of the 17 ORFs at the right end of U differ by more than 10%, with the notable exception of U94, the adeno-associated virus type 2 rep homolog, which differs by only 2.4%. This region also includes putative cis-acting sequences that are likely to be involved in transcriptional regulation of the major immediate-early locus. The catalog of variant-specific genetic differences resulting from our comparison of the genome sequences adds support to previous data indicating that HHV-6A and HHV-6B are distinct herpesvirus species.

Sequence-based information is an essential precursor to many molecular, biological, and epidemiologic studies. In addition, sequences are important for confirming or clarifying biological and taxonomic classifications, as illustrated for herpesviruses by experiences with Marek’s disease virus, channel catfish virus, and human herpesvirus 6 (HHV-6) (4, 9, 19). While the wealth of information obtained from smaller DNA segments is useful, genetic descriptions of viruses revealed through the determination and analysis of complete genome sequences are uniquely valuable. Thus, the analysis of 17 complete herpesvirus genome sequences has provided detailed information about their coding capacity and genetic architecture, revealing various permutations of conserved gene blocks and clusters of unique genes. This information yielded numerous insights into evolutionary paths within the herpesvirus family.

HHV-6 variants A and B (HHV-6A and HHV-6B) are classified as members of the Betaherpesvirinae subfamily, in the Roseolovirus genus along with human herpesvirus 7 (HHV-7) (47). These viruses share extensive domains of similar genetic organization with other betaherpesviruses, such as human cytomegalovirus (HCMV) (14, 19, 30, 40, 41, 48). The complete genome sequence for HHV-6A strain U1102 [HHV-6A(U1102)] was described by Gompels et al. (19).

HHV-6 was first described by Salahuddin and coworkers as a novel human herpesvirus isolated from the blood of patients with AIDS and other lymphoproliferative diseases (49). Reports describing the isolation of similar viruses soon followed (reviewed in reference 3), including from patients during the acute phase of the common childhood illness roseola or exanthem subitum (60). Characteristics shared by all of these viruses include infection of activated primary CD4+ T cells (33, 34, 54, 55), cross-reactive antigens (6, 43), and similar genomic organizations (30, 32, 36). As the cellular and molecular biologic properties of these viruses were investigated, it became evident that they segregate into two groups that differ with respect to several genetic and biological properties. To recognize the differences between these viruses, a system was established that classified them as either variant A or B. Classification was based on differences in nucleotide sequences, reactivity with panels of monoclonal antibodies, and cell tropism (1). The question of whether the HHV-6 variants should be recognized as distinct viral species was deferred pending the accumulation of additional information.

Although the viruses are closely related, there is no genetic gradient between HHV-6A and HHV6B, and recombinant viruses have never been detected. This situation is in contrast to that seen with the Epstein-Barr virus types, for which concentration of variant-specific changes in a small number of loci does not preclude intervariant recombination (25, 50). To understand the differences that may play a role in segregating the HHV-6 variants into discrete viral species, their genome sequences must be compared. In previous comparisons between subsets of HHV-6A and HHV-6B amino acid sequences, differences ranged from 1 to 5% in the set of genes shared by all herpesviruses (herpesvirus core genes), 19% in the gene encoding a strongly immunoreactive virion protein (U11), and 25% in the IE1 (U89) gene (8, 17, 29, 43, 59). In this report we present the genome sequence of HHV-6B strain Z29 [(HHV-6B(Z29)]. We describe its general organization, protein-coding potential, and relationship with the HHV-6A sequence.


Human Herpesvirus 6B Genome Sequence: Coding Content and Comparison with Human Herpesvirus 6A


Geraldina Dominguez,1 Timothy R. Dambaugh,2 Felicia R. Stamey,1 Stephen Dewhurst,3 Naoki Inoue,1 and Philip E. Pellett1,*

Publish date

1999 Oct;

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