2-Acetyl-5-bromo thiophene/Ketone, 5-bromo-2-thienyl methyl/1-(5-Bromo-2-thienyl)ethanone/Ethanone, 1-(5-bromo-2-thienyl)-/1-(5-bromothiophen-2-yl)ethanone/2-Acetyl-5-bromothiophene/1-(5-bromothien-2-yl)ethanone/5-Bromo-2-acetylthiophene/Ethanone, 1- (5-bromo-2-thienyl)-
252.8±0.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:5370-25-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
A motif essential for the transcriptional activation function 2 (AF-2) present in the E region of retinoic acid receptor (RAR) alpha and 9-cis retinoic acid receptor (RXR) alpha has been characterized as an amphipathic alpha-helix whose main features are conserved between transcriptionally active members of the nuclear receptor superfamily. This conserved motif, which can activate autonomously in the absence of ligand in animal and yeast cells, can be swapped between nuclear receptors without affecting the ligand dependency for activation of transcription, thus indicating that a ligand-dependent conformational change is necessary to reveal the AF-2 activation potential within the E region of the nuclear receptor. Interestingly, we show that the precise nature of the direct repeat response element to which RAR/RXR heterodimers are bound can affect the activity of the AF-2s of the heterodimeric partners, as well as the relative efficiency with which all-trans and 9-cis retinoic acids activate the RAR partner.
Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.
B Durand, M Saunders, C Gaudon, B Roy, R Losson, and P Chambon
1994 Nov 15
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J A Ohles and L Walton
The serum thymic factor (FTS) utilized in its synthetic or natural form loses its biological activity in a rosette assay after treatment with a metal ion-chelating agent, Chelex 100. This activity is restored by the addition of Zn salts and, to a lesser extent, certain other metal salts. FTS activation is secondary to the binding of the metal to the peptide. The metal-to-peptide molar ratio of 1:1 provides the best activation. These data indicate the existence of two forms of FTS. The first one lacks Zn and is biologically inactive; the second one contains Zn and is biologically active, for which we propose the name of “thymulin” (FTS-Zn). The presence of Zn in synthetic FTS was confirmed by atomic absorption spectrometry. The interaction between Zn and FTS was further suggested by microanalysis demonstrating the presence of this metal in thymic reticuloepithelial cells.
Contribution of zinc and other metals to the biological activity of the serum thymic factor.
M Dardenne, J M Pleau, B Nabarra, P Lefrancier, M Derrien, J Choay, and J F Bach