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2-Acetyl-5-bromothiophene

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1048

  • Specification : 99%(HPLC)

  • CAS number : 5370-25-2

  • Formula : C6H5BrOS

  • Molecular Weight : 205.07

  • PUBCHEM ID : 79335

  • Volume : 5mg

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Catalogue Number

BN-O1048

Analysis Method

Specification

99%(HPLC)

Storage

2-8°C

Molecular Weight

205.07

Appearance

Botanical Source

Structure Type

Category

SMILES

CC(=O)C1=CC=C(S1)Br

Synonyms

2-Acetyl-5-bromo thiophene/Ketone, 5-bromo-2-thienyl methyl/1-(5-Bromo-2-thienyl)ethanone/Ethanone, 1-(5-bromo-2-thienyl)-/1-(5-bromothiophen-2-yl)ethanone/2-Acetyl-5-bromothiophene/1-(5-bromothien-2-yl)ethanone/5-Bromo-2-acetylthiophene/Ethanone, 1- (5-bromo-2-thienyl)-

IUPAC Name

1-(5-bromothiophen-2-yl)ethanone

Density

1.6±0.1 g/cm3

Solubility

Flash Point

123.3±23.2 °C

Boiling Point

252.8±0.0 °C at 760 mmHg

Melting Point

94-96 °C(lit.)

InChl

InChl Key

IGBZCOWXSCWSHO-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:5370-25-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

7957103

Abstract

A motif essential for the transcriptional activation function 2 (AF-2) present in the E region of retinoic acid receptor (RAR) alpha and 9-cis retinoic acid receptor (RXR) alpha has been characterized as an amphipathic alpha-helix whose main features are conserved between transcriptionally active members of the nuclear receptor superfamily. This conserved motif, which can activate autonomously in the absence of ligand in animal and yeast cells, can be swapped between nuclear receptors without affecting the ligand dependency for activation of transcription, thus indicating that a ligand-dependent conformational change is necessary to reveal the AF-2 activation potential within the E region of the nuclear receptor. Interestingly, we show that the precise nature of the direct repeat response element to which RAR/RXR heterodimers are bound can affect the activity of the AF-2s of the heterodimeric partners, as well as the relative efficiency with which all-trans and 9-cis retinoic acids activate the RAR partner.

Title

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

Author

B Durand, M Saunders, C Gaudon, B Roy, R Losson, and P Chambon

Publish date

1994 Nov 15

PMID

8938340

Title

The Internet: a valuable resource for the hospital librarian

Author

J A Ohles and L Walton

Publish date

1996 Jan;

PMID

6957870

Abstract

The serum thymic factor (FTS) utilized in its synthetic or natural form loses its biological activity in a rosette assay after treatment with a metal ion-chelating agent, Chelex 100. This activity is restored by the addition of Zn salts and, to a lesser extent, certain other metal salts. FTS activation is secondary to the binding of the metal to the peptide. The metal-to-peptide molar ratio of 1:1 provides the best activation. These data indicate the existence of two forms of FTS. The first one lacks Zn and is biologically inactive; the second one contains Zn and is biologically active, for which we propose the name of “thymulin” (FTS-Zn). The presence of Zn in synthetic FTS was confirmed by atomic absorption spectrometry. The interaction between Zn and FTS was further suggested by microanalysis demonstrating the presence of this metal in thymic reticuloepithelial cells.

Title

Contribution of zinc and other metals to the biological activity of the serum thymic factor.

Author

M Dardenne, J M Pleau, B Nabarra, P Lefrancier, M Derrien, J Choay, and J F Bach

Publish date

1982 Sep;


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