2-Amino-5-nitro-2'-chlorbenzophenon/2'-chloro-5-nitro-2-aminobenzophenone/2-amino-5-nitro-2'-chlorobenzophenone/Clonazepam Related Compound B/(2-Amino-5-nitrophenyl)(2-chlorophenyl)methanone/2'-Chlor-5-nitro-2-amino-benzophenon/Methanone, (2-amino-5-nitrophenyl)(2-chlorophenyl)-/2-Amino-2-Chloro-5-Nitro Benzophenone/2-Amino-2'-chloro-5-nitrobenzophenone/METHANONE,(2-AMINO-5-NITROPHENYL)(2-CHLOROPHENYL)/Clonazepam,acid hydrolyzed/2-Amino-2'-chloro-5-nitro benzophenone/2-amino-2'-chloro-4-nitrobenzophenone
505.8±45.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:2011-66-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Gas Chromatographic Determination of Clonazepam
1980 Dec 12
A stability indicating, reversed phase high-performance liquid chromatographic method utilizing a smallbore HPLC column has been developed for the determination of clonazepam in a commercial tablet dosage form. The use of a small bore column results in a substantial solvent savings, as well as a greater mass sensitivity, especially in the identification of degradation peaks in a chromatogram. The method involves ultraviolet detection at 254 nm and utilized a 150 x 3.0 mm i.d. column packed with 3 microm octyldecylsilane particles with a mobile phase of water methanol acetonitrile (40:30:30, v/v/v) at a flow rate of 400 microl min(-1) at ambient temperature, with and without the use of 1,2-dichlorobenzene as the internal standard. The current USP method for the analysis of clonazepam using a 300 x 3.9 mm i.d. conventional octyldecylsilane column was utilized as a comparison to the smallbore method. The retention times for clonazepam and the internal standard on the 3.0 mm i.d. column were 4.0 and 12.5 min, respectively. The intra- and interday RSDs on the 3.0 mm i.d. column were < 0.55% (n =4) using the internal standard, and < 0.19% (n = 4) without the internal standard at the lower limit of the standard curve, 50 microg ml(-1) and had a limit of detection of 24 ng ml(-1). The assay using the 3.0 mm i.d. column was shown to be suitable for measuring clonazepam in a tablet dosage form.
Analysis of Clonazepam in a Tablet Dosage Form Using Smallbore HPLC
J C Spell 1, J T Stewart
The present review focuses on comparative studies of reconstruction with free flaps (FF) versus pedicled flaps (PF) after oncologic resection.
A systematic review was developed in compliance with PRISMA guidelines and performed using the Pubmed, Medline, EMBASE, Amed and Biosis databases.
A total of 30 articles were included. FF are associated with a longer operative time, a higher cost and a higher incidence of postoperative revisions compared to PF. FF are associated with a longer stay at the intensive care unit than the supraclavicular artery island flap (SCAIF) and with a more extended hospital stay compared to the submental island flap (SMIF). FF are associated with fewer infections and necrosis compared to the pectoralis major myocutaneous flap (PMMF).
The comparison of both type of flaps is limited by the inherent design of the studies included. In sum, FF seem superior to the PMMF for several outcomes. SMIF and SCAIF compare favorably to FF for some specific indications achieving similar outcomes at a lower cost.
Flaps, Oncology, Reconstruction, Surgery, Outcomes
Free versus pedicled flaps for reconstruction of head and neck cancer defects: a systematic review
Fanny Gabrysz-Forget,1 Paul Tabet,1 Akram Rahal,2 Eric Bissada,2 Apostolos Christopoulos,2 and Tareck Ayadcorresponding author2,3