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  • Brand : BIOFRON

  • Catalogue Number : BN-O1050

  • Specification : 99%(HPLC)

  • CAS number : 719-59-5

  • Formula : C13H10ClNO

  • Molecular Weight : 231.68

  • PUBCHEM ID : 12870

  • Volume : 5mg

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Catalogue Number


Analysis Method





Molecular Weight



Botanical Source

Structure Type





2-amino-5-chloro-benzophenone/ACB/2-Benzoyl-4-chloroaniline/2-Amino-5-chlorobenzophenone/Methanone, (2-amino-5-chlorophenyl)phenyl-/IFLAB-BB F1386-0355/ZR DG BVR/4-CHLORO-2-BENZOYLANILINE/OxazepaM Benzophenone/2--5/(2-Amino-5-chlorophenyl)(phenyl)methanone/475640/2-Amino-5-chloro




1.3±0.1 g/cm3


Flash Point

210.4±25.9 °C

Boiling Point

424.3±35.0 °C at 760 mmHg

Melting Point

96-98 °C(lit.)



InChl Key


WGK Germany


HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:719-59-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




Antibacterial/antibiofilm potential of microwave-assisted synthetic thirty-three 2-amino-5-chloro benzophenone Schiff bases have been carried out against four bacterial strains i.e. Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus and Streptococcus mutans. Among them compounds 5, 6, 8, 9, 14, 16, 22, 24, 26, and 30-32 showed antibiofilm activities against isolates at less than 100 μg/ml concentrations. These compounds showed enhanced antibiofilm activity against S. aureus as compared to cefixime used as control. However, remaining compounds were found to be active but at higher concentration. Fluorescence microscopy has been employed for confirmation of antibiofilm results. The structures of all synthetic molecules have been characterized on the basis of spectroscopic techniques including 1H NMR, 13C NMR, EI-MS, HREI-MS, and IR spectroscopy and their structure-activity relationship have been established.


2-Amino-5-chlorobenzophenone Schiff bases; Antibiofilm; Fluorescence microscopy; Klebsiella pneumonia; Microwave-assisted synthesis; Proteus mirabilis; Staphylococcus aureus; Streptococcus mutans.


Antibiofilm Potential of Synthetic 2-amino-5-chlorobenzophenone Schiff Bases and Its Confirmation Through Fluorescence Microscopy


Arshia 1, Anum Khalid Khan 2, Khalid Mohammed Khan 3, Ayaz Ahmed 2, Muhammad Taha 4, Shahnaz Perveen 5

Publish date

2017 Sep




Benzodiazepines are a large class of commonly-prescribed drugs used to treat a variety of clinical disorders. They have been shown to produce ecological effects at environmental concentrations, making understanding their fate in aquatic environments very important. In this study, uptake and biotransformations by riverine bacterio-plankton of the benzodiazepine, diazepam, and 2-amino-5-chlorobenzophenone, ACB (a photo-degradation product of diazepam and several other benzodiazepines), were investigated using batch microcosm incubations. These were conducted using water and bacterio-plankton populations from contrasting river catchments (Tamar and Mersey, UK), both in the presence and absence of a peptide, added as an alternative organic substrate. Incubations lasted 21 days, reflecting the expected water residence time in the catchments. In River Tamar water, 36% of diazepam (p < 0.001) was removed when the peptide was absent. In contrast, there was no removal of diazepam when the peptide was added, although the peptide itself was consumed. For ACB, 61% was removed in the absence of the peptide, and 84% in its presence (p < 0.001 in both cases). In River Mersey water, diazepam removal did not occur in the presence or absence of the peptide, with the latter again consumed, while ACB removal decreased from 44 to 22% with the peptide present. This suggests that bacterio-plankton from the Mersey water degraded the peptide in preference to both diazepam and ACB. Biotransformation products were not detected in any of the samples analysed but a significant increase in ammonium concentration (p < 0.038) was measured in incubations with ACB, confirming mineralization of the amine substituent. Sequential inoculation and incubation of Mersey and Tamar microcosms, for 5 periods of 21 days each, did not produce any evidence of increased ability of the microbial community to remove ACB, suggesting that an indigenous consortium was probably responsible for its metabolism. As ACB degradation was consistent, we propose that the aquatic photo-degradation of diazepam to ACB, followed by mineralization of ACB, is a primary removal pathway for these emerging contaminants. As ACB is photo-produced by several benzodiazepines, this pathway should be relevant for the removal of other benzodiazepines that enter the freshwater environment.


Bacterio-plankton Transformation of Diazepam and 2-amino-5-chlorobenzophenone in River Waters


Alan D Tappin 1, J Paul Loughnane, Alan J McCarthy, Mark F Fitzsimons

Publish date





Previously we described a series of 5-acylaminobenzophenones with considerable antimalarial activity. Unfortunately, most compounds also displayed high cytotoxicity resulting in low selectivity towards malaria parasites. Through the replacement of the 5-acylamino moiety by simple chlorine and further modifications of the 2-acylamino residue we could obtain inhibitors with improved selectivity towards malaria parasites combined with an acceptable reduction of antimalarial activity.

Copyright © 2011 Elsevier Masson SAS. All rights reserved.


2-Acylamino-5-chlorobenzophenones With Enhanced Selectivity Towards Malaria Parasites


Swetlana Heinrich 1, Mirko Altenkamper, Benjamin Bechem, Johann Perruchon, Regina Ortmann, Hans-Martin Dahse, Yulin Wang, Michael Lanzer, Martin Schlitzer

Publish date

2011 Apr;

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