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2-Aminonicotinic acid

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1174

  • Specification : 98%(HPLC)

  • CAS number : 5345-47-1

  • Formula : C6H6N2O2

  • Molecular Weight : 138.12

  • PUBCHEM ID : 72930

  • Volume : 5mg

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Catalogue Number

BN-O1174

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

138.12

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC(=C(N=C1)N)C(=O)O

Synonyms

2-Aminopyridine-3-carboxylic acid/2-Amino-3-pyridinecarboxylic acid/2-Aminonicotinic acid/Nicotinic acid, 2-amino-/T6NJ BZ CVQ

IUPAC Name

2-aminopyridine-3-carboxylic acid

Density

1.4±0.1 g/cm3

Solubility

Flash Point

160.8±23.7 °C

Boiling Point

342.3±27.0 °C at 760 mmHg

Melting Point

295-297 °C (dec.)(lit.)

InChl

InChl Key

KPIVDNYJNOPGBE-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:5345-47-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26945123

Abstract

We synthesized 2-aminonicotinic acid (2-ANA) complexes with metals such as Co(II), Fe(III), Ni(II), Mn(II), Zn(II), Ag(I),Cr(III), Cd(II) and Cu(II) in aqueous media. The complexes were characterized and elucidated using FT-IR, UV-Vis, a fluorescence spectrophotometer and thermo gravimetric analysis (TGA). TGA data showed that the stoichiometry of complexes was 1:2 metal/ligand except for Ag(I) and Mn(II) where the ratio was 1:1. The metal complexes showed varied antibacterial, fungicidal and nematicidal activities. The silver and zinc complexes showed highest activity against Bacillus subtilis and Bacillus licheniformis respectively. Fusarium oxysporum was highly susceptible to nickel and copper complexes whereas Macrophomina phaseolina was completely inert to the complexes. The silver and cadmium complexes were effective against the root-knot nematode Meloidogyne javanica.

KEYWORDS

2-Aminonicotinic acid; Biological activity; Metal complexes; Spectral studies.

Title

Synthesis, Spectral Studies and Biological Evaluation of 2-aminonicotinic Acid Metal Complexes

Author

Muhammad Nawaz 1, Muhammad Waseem Abbasi 2, Soleiman Hisaindee 3, Muhammad Javed Zaki 2, Hira Fatima Abbas 4, Hu Mengting 5, M Arif Ahmed 6

Publish date

2016 May 15

PMID

9362553

Abstract

2-Aminonicotinic acid, C6H6N2O2, crystallized in the centrosymmetric space group P2(1)/c in the zwitterionic form. Intermolecular N–H…O hydrogen bonds with N…O distances of 2.652 (2) and 2.807 (2) A link molecules into two sets of zigzag chains propagating along the b axis. The two sets of chains are crosslinked by C–H…O interactions. The dihedral angle between the planes of adjacent molecules in a chain is 9.77 (7) degrees. An intramolecular N–H…O hydrogen bond is also present.

Title

2-Aminonicotinic Acid

Author

A J Dobson 1, R E Gerkin

Publish date

1997 Oct 15

PMID

24274468

Abstract

3-Hydroxyanthranilic acid 3,4-dioxygenase (3-HAO) is the enzyme responsible for the production of the neurotoxic tryptophan metabolite quinolinic acid (QUIN). Elevated brain levels of QUIN are observed in several neurodegenerative diseases, but pharmacological investigation on its role in the pathogenesis of these conditions is difficult because only one class of substrate-analogue 3-HAO inhibitors, with poor chemical stability, has been reported so far. Here we describe the design, synthesis, and biological evaluation of a novel class of chemically stable inhibitors based on the 2-aminonicotinic acid 1-oxide nucleus. After the preliminary in vitro evaluation of newly synthesized compounds using brain tissue homogenate, we selected the most active inhibitor and showed its ability to acutely reduce the production of QUIN in the rat brain in vivo. These findings provide a novel pharmacological tool for the study of the mechanisms underlying the onset and propagation of neurodegenerative diseases.

Title

2-Aminonicotinic Acid 1-oxides Are Chemically Stable Inhibitors of Quinolinic Acid Synthesis in the Mammalian Brain: A Step Toward New Antiexcitotoxic Agents

Author

Gian Paolo Vallerini 1, Laura Amori, Claudia Beato, Margarita Tararina, Xiao-Dan Wang, Robert Schwarcz, Gabriele Costantino

Publish date

2013 Dec 12


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