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2-Benzothiazolol

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1080

  • Specification : 98%(HPLC)

  • CAS number : 934-34-9

  • Formula : C7H5NOS

  • Molecular Weight : 151.19

  • PUBCHEM ID : 13625

  • Volume : 5mg

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Catalogue Number

BN-O1080

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

151.19

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC=C2C(=C1)NC(=O)S2

Synonyms

1,3-Benzothiazol-2(3H)-one/2-Benzothiazolol/2(3H)-Benzothiazolone/2-Hydroxybenzothiazole/Benzo[d]thiazol-2-ol/benzothiazolinone

IUPAC Name

3H-1,3-benzothiazol-2-one

Density

1.4±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

171.5±19.3 °C

Boiling Point

360.0±11.0 °C at 760 mmHg

Melting Point

137-140 °C(lit.)

InChl

InChl Key

YEDUAINPPJYDJZ-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:934-34-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26884060

Abstract

High-throughput screening for potential thyroid-disrupting chemicals requires a system of assays to capture multiple molecular-initiating events (MIEs) that converge on perturbed thyroid hormone (TH) homeostasis. Screening for MIEs specific to TH-disrupting pathways is limited in the U.S. Environmental Protection Agency ToxCast screening assay portfolio. To fill 1 critical screening gap, the Amplex UltraRed-thyroperoxidase (AUR-TPO) assay was developed to identify chemicals that inhibit TPO, as decreased TPO activity reduces TH synthesis. The ToxCast phase I and II chemical libraries, comprised of 1074 unique chemicals, were initially screened using a single, high concentration to identify potential TPO inhibitors. Chemicals positive in the single-concentration screen were retested in concentration-response. Due to high false-positive rates typically observed with loss-of-signal assays such as AUR-TPO, we also employed 2 additional assays in parallel to identify possible sources of nonspecific assay signal loss, enabling stratification of roughly 300 putative TPO inhibitors based upon selective AUR-TPO activity. A cell-free luciferase inhibition assay was used to identify nonspecific enzyme inhibition among the putative TPO inhibitors, and a cytotoxicity assay using a human cell line was used to estimate the cellular tolerance limit. Additionally, the TPO inhibition activities of 150 chemicals were compared between the AUR-TPO and an orthogonal peroxidase oxidation assay using guaiacol as a substrate to confirm the activity profiles of putative TPO inhibitors. This effort represents the most extensive TPO inhibition screening campaign to date and illustrates a tiered screening approach that focuses resources, maximizes assay throughput, and reduces animal use.

KEYWORDS

endocrine, thyroid < endocrine toxicology in vitro and altenatives, predictive toxicology < in vitro and altenatives

Title

Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

Author

Katie Paul Friedman,corresponding author*†,2 Eric D. Watt,*‡,2 Michael W. Hornung,§ Joan M. Hedge,† Richard S. Judson,‡ Kevin M. Crofton,‡ Keith A. Houck,‡ and Steven O. Simmons‡,1

Publish date

2016 May;


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