Catalogue Number
BN-O1086
Analysis Method
Specification
98%(HPLC)
Storage
2-8°C
Molecular Weight
282.5
Appearance
Botanical Source
Structure Type
Category
SMILES
CCN(CC)C(=S)SC1=NC2=CC=CC=C2S1
Synonyms
Diaethyl-dithiocarbamidsaeure-benzothiazol-2-ylester/diethyl-dithiocarbamic acid benzothiazol-2-yl ester/benzothiazol-2-yl diethyldithiocarbamate/Diethyldithiocarbamic acid,2-benzothiazolyl ester/2-Benzothiazyl N,N-diethylthiocarbamoyl sulfide/2-Benzothiazyl-N,N-diethylthiocarbamylsulfide/Ethylac/2-Benzothiazolyl diethyldithiocarbamate/N,N-Diethylthiocarbamoyl 2-benzothiazolyl sulfide
IUPAC Name
1,3-benzothiazol-2-yl N,N-diethylcarbamodithioate
Density
1.31g/cm3
Solubility
DMSO
Flash Point
190.4ºC
Boiling Point
391.3ºC at 760 mmHg
Melting Point
79ºC
InChl
InChl Key
LFMQNMXVVXHZCC-UHFFFAOYSA-N
WGK Germany
RID/ADR
HS Code Reference
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:95-30-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
23672493
Background
Cisplatin (CDDP) is the most frequently used chemotherapeutic agent for various types of advanced cancer, including gastric cancer. However, almost all cancer cells acquire resistance against CDDP, and this phenomenon adversely affects prognosis. Thus, new chemotherapeutic agents that can overcome the CDDP-resistant cancer cells will improve the survival of advanced cancer patients.
Methods
We synthesized new glycoconjugated platinum (II) and palladium (II) complexes, [PtCl2 (L)] and [PdCl2 (L)]. CDDP-resistant gastric cancer cell lines were established by continuous exposure to CDDP, and gene expression in the CDDP-resistant gastric cancer cells was analyzed. The cytotoxicity and apoptosis induced by [PtCl2 (L)] and [PdCl2 (L)] in CDDP-sensitive and CDDP-resistant gastric cancer cells were evaluated. DNA double-strand breaks by drugs were assessed by evaluating phosphorylated histone H2AX. Xenograft tumor mouse models were established and antitumor effects were also examined in vivo.
Results
CDDP-resistant gastric cancer cells exhibit ABCB1 and CDKN2A gene up-regulation, as compared with CDDP-sensitive gastric cancer cells. In the analyses of CDDP-resistant gastric cancer cells, [PdCl2 (L)] overcame cross-resistance to CDDP in vitro and in vivo. [PdCl2 (L)] induced DNA double-strand breaks.
Conclusion
These results indicate that [PdCl2 (L)] is a potent chemotherapeutic agent for CDDP-resistant gastric cancer and may have clinical applications.
Glycoconjugated platinum (II) complex, Glycoconjugated palladium (II) complex, Cisplatin, Drug resistance, Gastric cancer
Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells
Mamoru Tanaka,1 Hiromi Kataoka,corresponding author1 Shigenobu Yano,2,3 Hiromi Ohi,4 Keisuke Kawamoto,5 Takashi Shibahara,5 Tsutomu Mizoshita,1 Yoshinori Mori,1 Satoshi Tanida,1 Takeshi Kamiya,1 and Takashi Joh1
2013;
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