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2-Benzylaminopyridine

$53

  • Brand : BIOFRON

  • Catalogue Number : BN-O1119

  • Specification : 98%(HPLC)

  • CAS number : 6935-27-9

  • Formula : C12H12N2

  • Molecular Weight : 184.24

  • PUBCHEM ID : 23362

  • Volume : 5mg

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Catalogue Number

BN-O1119

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

184.24

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC=C(C=C1)CNC2=CC=CC=N2

Synonyms

N-benzylpyridin-2-amine

IUPAC Name

N-benzylpyridin-2-amine

Density

1.131 g/cm3

Solubility

Flash Point

182°C/12mm

Boiling Point

116-131 °C0.6 mm Hg(lit.)

Melting Point

95-97 °C(lit.)

InChl

InChl Key

WYHXNQXDQQMTQI-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:6935-27-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

138213

Title

The Acute Toxicity of 2-benzylaminopyridine

Author

L C Griffis, R B Forney

Publish date

Dec-76

PMID

8692922

Abstract

RNA polymerases encounter specific DNA sites at which RNA chain elongation takes place in the absence of enzyme translocation in a process called discontinuous elongation. For RNA polymerase II, at least some of these sequences also provoke transcriptional arrest where renewed RNA polymerization requires elongation factor SII. Recent elongation models suggest the occupancy of a site within RNA polymerase that accommodates nascent RNA during discontinuous elongation. Here we have probed the extent of nascent RNA extruded from RNA polymerase II as it approaches, encounters, and departs an arrest site. Just upstream of an arrest site, 17-19 nucleotides of the RNA 3′-end are protected from exhaustive digestion by exogenous ribonuclease probes. As RNA is elongated to the arrest site, the enzyme does not translocate and the protected RNA becomes correspondingly larger, up to 27 nucleotides in length. After the enzyme passes the arrest site, the protected RNA is again the 18-nucleotide species typical of an elongation-competent complex. These findings identify an extended RNA product groove in arrested RNA polymerase II that is probably identical to that emptied during SII-activated RNA cleavage, a process required for the resumption of elongation. Unlike Escherichia coli RNA polymerase at a terminator, arrested RNA polymerase II does not release its RNA but can reestablish the normal elongation mode downstream of an arrest site. Discontinuous elongation probably represents a structural change that precedes, but may not be sufficient for, arrest by RNA polymerase II.

Title

Increased accommodation of nascent RNA in a product site on RNA polymerase II during arrest.

Author

W Gu, M Wind, and D Reines

Publish date

1996 Jul 9

PMID

9261421

Abstract

To investigate enhanced disease associated with a formalin-inactivated (FI) respiratory syncytial virus (RSV) vaccine, we studied the pulmonary inflammatory response to RSV in BALB/c mice immunized with live RSV, FI-RSV, or combinations of the two. After RSV challenge, the number of granular cells, the ratio of CD4+/CD8+ lymphocytes, and the level of Th2-like cytokine mRNAs in the bronchoalveolar lavage specimens in mice immunized first with live RSV and then with FI-RSV were lower than that in FI-RSV-immunized mice and close to that in live RSV-immunized mice. These data suggest that prior live RSV infection prevents most of the enhanced inflammatory response seen in FI-RSV-immunized mice and might explain lack of enhanced disease in older FI-RSV-immunized children. A live RSV vaccine might similarly decrease the risk of enhanced disease with non-live RSV vaccines.

Title

Priming with live respiratory syncytial virus (RSV) prevents the enhanced pulmonary inflammatory response seen after RSV challenge in BALB/c mice immunized with formalin-inactivated RSV.

Author

M E Waris, C Tsou, D D Erdman, D B Day, and L J Anderson

Publish date

1997 Sep;


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