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2-(Chloromethyl)-4-methylquinazoline

$72

  • Brand : BIOFRON

  • Catalogue Number : BN-O1201

  • Specification : 98%(HPLC)

  • CAS number : 109113-72-6

  • Formula : C10H9ClN2

  • Molecular Weight : 192.64

  • PUBCHEM ID : 241518

  • Volume : 5mg

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Catalogue Number

BN-O1201

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

192.64

Appearance

Botanical Source

Structure Type

Category

SMILES

CC1=NC(=NC2=CC=CC=C12)CCl

Synonyms

2-chloromethyl-4-methylquinazoline/Quinazoline, 2-(chloromethyl)-4-methyl-/2-(Chloromethyl)-4-methylquinazoline/2-Chloromethyl-4-methylchinazolin/2-(3-HYDROXY-5-METHOXY-2-PROPYLPHENYL)ACETIC ACID/2-(chloro methyl)-4-methyl quinazoline

IUPAC Name

2-(chloromethyl)-4-methylquinazoline

Density

1.3±0.1 g/cm3

Solubility

Flash Point

122.1±10.7 °C

Boiling Point

240.0±32.0 °C at 760 mmHg

Melting Point

61 - 63ºC

InChl

InChl Key

UHCUBOJGMLASBY-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:109113-72-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30944754

Abstract

A stability-indicating LC method was developed for quantification of linagliptin (LGT) and three synthetic impurities. The method utilizes a Thermo Scientific® RP-8 column (100 mm × 4.6 mm; 5 μm) with the PDA detector for quantitation of impurities. A mixture of 0.1% formic acid with pH 3.5 (A) and acetonitrile (B) was used as the mobile phase at a flow rate of 0.6 mL·min−1 with gradient elution. The percentage of mobile phase B increases from 30% to 70% over 5 min and decreases from 70% to 30% between 5 and 8 min. The method was validated according to International Council for Harmonization (ICH) guidelines. The LOD values obtained were 0.0171 μg·mL−1 and 0.015 μg·mL−1 for LGT and impurities, respectively. The LOQ values were 0.06 μg·mL−1 for LGT and impurities. In all cases, the correlation coefficients of LGT and impurities were >0.999, showing the linearity of the method. The % recovery of the LGT and added impurity were in the range of 92.92-99.79%. The precision of the method showed values less than 1.47% for LGT and less than 4.63% for impurities. The robustness was also demonstrated by small modifications in the chromatographic conditions. The selectivity was evidenced because the degradation products formed in stress conditions did not interfere in the determination of LGT and impurities. Toxicity prediction studies suggested toxicity potential of the impurities, which was confirmed using biological safety studies in vitro.

Title

Biological Safety Studies and Simultaneous Determination of Linagliptin and Synthetic Impurities by LC-PDA

Author

Raquel Balestri Heleno Ferreira, 1 , 2 Jonathaline Apollo Duarte, 2 , 3 Flavio Dias Ferreira, 2 Luis Flavio Souza de Oliveira, 2 , 3 Michel Mansur Machado, 2 , 3 Marcelo Donadel Malesuik, 2 , 3 Favero Reisdorfer Paula, 1 , 2 Martin Steppe, 4 Elfrides Eva Shermann Schapoval, 4 and Clesio Soldateli Paimcorresponding author 1 , 2

Publish date

2019;


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