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2-(Cyanomethyl)benzimidazole

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1076

  • Specification : 98%(HPLC)

  • CAS number : 4414-88-4

  • Formula : C9H7N3

  • Molecular Weight : 157.17

  • PUBCHEM ID : 20455

  • Volume : 5mg

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Catalogue Number

BN-O1076

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

157.17

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC=C2C(=C1)NC(=N2)CC#N

Synonyms

1H-Benzimidazol-2-ylacetonitrile/(1H-BENZOIMIDAZOL-2-YL)-ACETONITRILE/2-(1H-benzo[d]imidazol-2-yl)acetonitrile/1H-Benzimidazole-2-acetonitrile/2-(Cyanomethyl)benzimidazole

IUPAC Name

2-(1H-benzimidazol-2-yl)acetonitrile

Density

1.3±0.1 g/cm3

Solubility

Flash Point

142.5±9.2 °C

Boiling Point

439.5±28.0 °C at 760 mmHg

Melting Point

200-205 °C (dec.)(lit.)

InChl

InChl Key

BWOVACANEIVHST-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:4414-88-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

1852008

Abstract

Interleukin 6 (IL-6) has been shown to inhibit the proliferation, but increase the motility, of wild-type ZR-75-1 human ductal breast carcinoma cells, a line of cells that resemble closely the malignant cells cultured from the ascitic effusion. IL-6-treated cells lose their epithelial character, become stellate or fusiform in shape, and migrate away from neighbors. In the wild-type ZR-75-1 cells, IL-6 causes cell-cell separation in preformed colonies as well as postmitotically. We have now investigated the action of IL-6 in clone B ZR-75-1 cells, which are morphologically distinct from wild-type ZR-75-1 cells. In the more polygonal rather than cuboidal clone B cells, IL-6 did not cause early inhibition of DNA synthesis and it caused little cell-cell separation in preformed colonies. However, IL-6 treatment markedly prolonged the interval between mitosis and readherence of daughter cells to their neighbors and the substratum. Supernatants from IL-6-treated cultures contained detached viable cells in increased numbers. Intermitotic intervals were prolonged in IL-6-treated cultures. IL-6-treated dividing breast carcinoma cells are characterized by an increased probability of separation from neighbors and the substratum.

Title

Decreased adherence of interleukin 6-treated breast carcinoma cells can lead to separation from neighbors after mitosis.

Author

I Tamm, I Cardinale, and J S Murphy

Publish date

1991 May 15;

PMID

3859870

Abstract

The induction of heat shock proteins in three species of Leishmania, L. tropica, L. enrietti, and L. donovani is reported. When cultures of promastigotes are shifted from 26 degrees C to 37 degrees C or 40 degrees C, the synthesis of proteins with apparent molecular weights of 88,000, 74,000, and 54,000 is stimulated. Actinomycin D added just prior to the shift prevented the appearance of these proteins but had no effect when present 30 min after the transfer onward, suggesting that the regulation of leishmanial heat shock proteins occurs at the transcriptional level. Exposure of L. tropica promastigotes to sodium arsenite elicits the synthesis of three major and four minor polypeptides. Their apparent molecular weights are, respectively, 94,000, 78,000, and 56,000 and 70,000, 45,000, 22,000, and 18,000. The response of Leishmania organisms to heat shock and to sodium arsenite is similar to that of other organisms, but some of the proteins identified as stress proteins in the parasite differ in size. The heat shock proteins might play a role in cytodifferentiation during the life cycle of the parasite and also in cellular adaptation to higher temperatures.

Title

Induction of heat shock and stress proteins in promastigotes of three Leishmania species.

Author

F Lawrence and M Robert-Gero

Publish date

1985 Jul

PMID

8415014

Title

High efficiency transformation of Saccharomyces cerevisiae by electroporation.

Author

P Manivasakam and R H Schiestl

Publish date

1993 Sep 11


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