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2-Naphthyl N-benzoylphenylalaninate

$140

  • Brand : BIOFRON

  • Catalogue Number : BN-O1132

  • Specification : 98%(HPLC)

  • CAS number : 15873-25-3

  • Formula : C26H21NO3

  • Molecular Weight : 395.4

  • PUBCHEM ID : 102757

  • Volume : 5mg

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Catalogue Number

BN-O1132

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

395.4

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC=C(C=C1)CC(C(=O)OC2=CC3=CC=CC=C3C=C2)NC(=O)C4=CC=CC=C4

Synonyms

N-Benzoyl-DL-phenylalanine 2-Naphthyl Ester/Benzoylphenylalaninenaphtylester/N-Benzoyl-DL-phenylalanine 2-Naphtyl ester/fordeterminationofchymotrypsin

IUPAC Name

naphthalen-2-yl 2-benzamido-3-phenylpropanoate

Density

1.222g/cm3

Solubility

Flash Point

350.9ºC

Boiling Point

656.6ºC at 760 mmHg

Melting Point

158ºC

InChl

InChl Key

NPPKNSHRAVHLHD-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:15873-25-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28627515

Abstract

Clathrin-mediated endocytosis (CME) involves membrane-associated scaffolds of the bin-amphiphysin-rvs (BAR) domain protein family as well as the GTPase dynamin, and is accompanied and perhaps triggered by changes in local lipid composition. How protein recruitment, scaffold assembly and membrane deformation is spatiotemporally controlled and coupled to fission is poorly understood. We show by computational modelling and super-resolution imaging that phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] synthesis within the clathrin-coated area of endocytic intermediates triggers selective recruitment of the PX-BAR domain protein SNX9, as a result of complex interactions of endocytic proteins competing for phospholipids. The specific architecture induces positioning of SNX9 at the invagination neck where its self-assembly regulates membrane constriction, thereby providing a template for dynamin fission. These data explain how lipid conversion at endocytic pits couples local membrane constriction to fission. Our work demonstrates how computational modelling and super-resolution imaging can be combined to unravel function and mechanisms of complex cellular processes.

Title

Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission

Author

Johannes Schoneberg,1,*‡ Martin Lehmann,2,3,‡ Alexander Ullrich,1 York Posor,2,3 Wen-Ting Lo,2 Gregor Lichtner,1,2 Jan Schmoranzer,a,2,3,† Volker Haucke,b,2,3,4 and Frank Noec,1

Publish date

2017;

PMID

26976672

Abstract

A pilot cross sectional study was conducted to investigate the role of red blood cells (RBC) deformability in type 2 diabetes mellitus (T2DM) without and with diabetic retinopathy (DR) using a dual optical tweezers stretching technique. A dual optical tweezers was made by splitting and recombining a single Nd:YAG laser beam. RBCs were trapped directly (i.e., without microbead handles) in the dual optical tweezers where they were observed to adopt a “side-on” orientation. RBC initial and final lengths after stretching were measured by digital video microscopy, and a Deformability index (DI) calculated. Blood from 8 healthy controls, 5 T2DM and 7 DR patients with respective mean age of 52.4yrs, 51.6 yrs and 52 yrs was analysed. Initial average length of RBCs for control group was 8.45 ± 0.25 μm, 8.68 ± 0.49 μm for DM RBCs and 8.82 ± 0.32 μm for DR RBCs (p < 0.001). The DI for control group was 0.0698 ± 0.0224, and that for DM RBCs was 0.0645 ± 0.03 and 0.0635 ± 0.028 (p < 0.001) for DR group. DI was inversely related to basal length of RBCs (p = 0.02). DI of RBC from DM and DR patients was significantly lower in comparison with normal healthy controls. A dual optical tweezers method can hence be reliably used to assess RBC deformability.

Title

Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique

Author

Rupesh Agrawal,a,1,2,3,4 Thomas Smart,5 João Nobre-Cardoso,1 Christopher Richards,5 Rhythm Bhatnagar,2 Adnan Tufail,1 David Shima,3 Phil H. Jones,5 and Carlos Pavesio1,3

Publish date

2016

PMID

12456877

Abstract

The process by which liquid cloud droplets homogeneously crystallize into ice is still not well understood. The ice nucleation process based on the standard and classical theory of homogeneous freezing initiates within the interior volume of a cloud droplet. Current experimental data on homogeneous freezing rates of ice in droplets of supercooled water, both in air and emulsion oil samples, show considerable scatter. For example, at −33°C, the reported volume-based freezing rates of ice in supercooled water vary by as many as 5 orders of magnitude, which is well outside the range of measurement uncertainties. Here, we show that the process of ice nucleus formation at the air (or oil)-liquid water interface may help to explain why experimental results on ice nucleation rates yield different results in different ambient phases. Our results also suggest that surface crystallization of ice in cloud droplets can explain why low amounts of supercooled water have been observed in the atmosphere near −40°C.

Title

Surface crystallization of supercooled water in clouds

Author

A. Tabazadeh,*† Y. S. Djikaev,‡ and H. Reiss‡

Publish date

2002 Dec 10;


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