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2”-O-Galloylhyperin

$178

  • Brand : BIOFRON

  • Catalogue Number : BF-O2011

  • Specification : 98%

  • CAS number : 53209-27-1

  • Formula : C28H24O16

  • Molecular Weight : 616.48

  • PUBCHEM ID : 6453359

  • Volume : 20mg

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Catalogue Number

BF-O2011

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

616.48

Appearance

Yellow crystalline powder

Botanical Source

Pyrola calliantha

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)O)O

Synonyms

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 2-O-(3,4,5-trihydroxybenzoyl)-β-D-galactopyranoside/2'-O-(2-METHOXYETHYL)CYTIDINE/4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[[2-O-(3,4,5-trihydroxybenzoyl)-β-D-galactopyranosyl]oxy]-/2"-O-Galloylhyperin/2''-O-Galloylhyperin

IUPAC Name

[(2S,3R,4S,5R,6R)-2-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] 3,4,5-trihydroxybenzoate

Density

1.9±0.1 g/cm3

Solubility

Methanol

Flash Point

365.6±27.8 °C

Boiling Point

1106.9±65.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C28H24O16/c29-8-18-21(37)23(39)26(43-27(40)10-4-15(34)20(36)16(35)5-10)28(42-18)44-25-22(38)19-14(33)6-11(30)7-17(19)41-24(25)9-1-2-12(31)13(32)3-9/h1-7,18,21,23,26,28-37,39H,8H2/t18-,21+,23+,26-,28+/m1/s1

InChl Key

PXGWEUQZDRUMRE-UNZYZCBSSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:53209-27-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

24375731

Abstract

An LC-MS/MS method was developed for the first time to simultaneously determine hyperoside and 2”-O-galloylhyperin, two major components in Pyrola calliantha extract, in rat plasma. Following extraction by one-step protein precipitation with methanol, the analytes were separated on a Venusil MP-C18 column within 2 min, using methanol-water-formic acid (50:50:0.1, v/v/v) as the mobile phase at a flow rate of 0.4 mL/min. Detection was performed on electrospray negative ionization mass spectrometry by multiple-reaction monitoring of the transitions of 2”-O-galloylhyperin at m/z 615.1 → 301.0, of hyperoside at m/z 463.1 → 300.1, and of internal standard at m/z 415.1 → 295.1. The limits of quantification were 2 ng/mL for both hyperoside and 2”-O-galloylhyperin. The precisions were <13.1%, and the accuracies were between -9.1 and 5.5% for both compounds. The method was successfully applied in pharmacokinetic studies following intravenous administration of the total flavonoids of P. calliantha extract in rats.

Copyright © 2013 John Wiley & Sons, Ltd.

KEYWORDS

2′′-O-galloylhyperin; LC-MS/MS; hyperoside; pharmacokinetic study; simultaneous determination

Title

Validated LC-MS/MS method for the simultaneous determination of hyperoside and 2''-O-galloylhyperin in rat plasma: application to a pharmacokinetic study in rats.

Author

Zhou D1, Jin Y, Yao F, Duan Z, Wang Q, Liu J.

Publish date

2014 Aug


Description :

2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage[1][2].