2-Phenylmethoxy naphthalenen/L66J CO1R/2-(Phenylmethoxy)naphthalene/Benzyl 2-naphthyl ether/2-(Benzyloxy)naphthalene/Naphthalene, 2-(phenylmethoxy)-/2-phenylmethoxynaphthalene/2-(PENZYLOXY)-NAPHTHALENE
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provides coniferyl ferulate(CAS#:613-62-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
The in vitro potential of sensitizers and related compounds (SRCs) originating from impurities in waste paper in activating the human aryl hydrocarbon receptor (AhR) α was assessed using yeast reporter gene as well as cytochrome P450 (CYP)1A1 and ethoxyresorufin O-deethylase (EROD) assays. In the yeast assay, eight compounds exhibited agonist activity, and their activity relative to β-naphthoflavone (BNF) ranged from 1.4 × 10(-4) to 8.3 × 10(-2), with the highest activity observed for benzyl 2-naphthyl ether (BNE). In the EROD assay, six compounds caused a more significant induction of CYP1A-dependent activity than did the vehicle control at 50 μM (p<0.01), and their induction levels were 5.1- to 11-fold more potent; 1,2-bis(3-methylphenoxy)ethane (BME) was the most effective inducer. The water from the waste paper recycling area was fractioned using solid-phase extraction (SPE) combined with a C18 disk and florisil cartridge. In gas chromatography-mass spectrometry (GC-MS) analysis, SRCs were detected in the first fraction, at a total concentration of 5.5 μg/L. This fraction also activated AhR, and its activity, expressed as a BNF equivalent value, was 0.42 nM in the yeast assay. The contribution ratio of active compounds accounted for up to 34% and 4.4% observed activity of the fraction and total samples, respectively. To our knowledge, this is the first study to show that paper industry-related compounds, namely aromatic sensitizers, activate AhR by using a yeast assay and HepG2 cells.
Aromatic sensitizers; Effect-directed analysis; Human HepG2 ethoxyresorufin O-deethylase assay; Human aryl hydrocarbon receptor α; Paper mill effluent; Yeast YCM3 assay.
Evaluation of Sensitizers Found in Wastewater From Paper Recycling Areas, and Their Activation of the Aryl Hydrocarbon Receptor in Vitro
Masanori Terasaki 1, Michiko Yasuda 2, Kayoko Shimoi 2, Kazuhiko Jozuka 2, Masakazu Makino 2, Fujio Shiraishi 3, Daisuke Nakajima 3
2014 Sep 15
Applications of differential pulse anodic stripping voltammetry using a new pen-type renewed hanging mercury electrode have been investigated for trace analysis of lead in pharmaceutical substances and intermediates of their syntheses, such as procaine hydrochloride, 4-aminobenzoic acid, methyl 4-aminobenzoate, 2-(4-chlor-3-aminobenzoyl) benzoic acid, benzyl 2-naphthyl ether, 5-aminoisophthalic acid, 3-aminobenzoic acid, 5-hydroxyisophthalic acid, and N, N’-dibenzylethylenediamine diacetate. Samples were dissolved in 1 M HCI or 1 M NaOH and the electrochemical scan was carried out. No sample mineralization was necessary. The method showed a good linearity up to 50-100 ppm Pb with a detection limit less than 100 ppb. The results agreed well, but were more precise than those obtained by atomic absorption spectrometry using air/acetylene flame atomisation.
Application of Stripping Voltammetry to Trace Lead Analysis in Intermediates and Final Products of Syntheses of Pharmaceuticals
M Pravda 1, K Vytras
Although adjuvant chemotherapy (AC) has been established as a standard of treatment for advanced rectal cancer, there is no guideline regarding the timing of AC initiation. In this study, we aimed to evaluate the oncologic outcome of early AC initiation and clarify the ideal time to AC among rectal cancer patients receiving preoperative chemo-radiotherapy (preCRT).
The medical records of 719 patients who underwent curative resection followed by AC for rectal cancer were analyzed retrospectively. Data distributions were compared according to the calculated cut-off for AC initiation, survival results, and chemotherapy-induced toxicity. Additionally, patients were divided into two groups according to preCRT status and compared with respect to differences in the optimal time to AC.
Overall, a cut-off time point of 20 days after surgery for AC initiation was identified as the optimal interval; this yielded a significant difference in disease-free survival but no significant difference in AC toxicity. In the cut-off analysis of patients treated without preCRT, 19 days was identified as the optimal time to AC. However, for patients treated with preCRT, no significant value affected the survival outcome.
Earlier initiation of AC (within approximately 3 weeks) was associated with better oncological outcomes among patients with rectal cancer. Additionally, the optimal timing of AC was unclear among patients who received preCRT; this might be attributable to an undetermined role of AC after preCRT or the effects of complications such as anastomotic leakage.
The impact of early adjuvant chemotherapy in rectal cancer
Gyoung Tae Noh, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing - original draft, Writing - review & editing,1 Jeonghee Han, Data curation, Investigation,2 Min Soo Cho, Data curation, Resources, Writing - review & editing,3 Hyuk Hur, Data curation, Resources, Writing - review & editing,3 Kang Young Lee, Data curation, Resources, Writing - review & editing,3 Nam Kyu Kim, Data curation, Resources, Writing - review & editing,3 and Byung Soh Min, Conceptualization, Data curation, Investigation, Methodology, Resources, Supervision, Validation, Writing - review & editing3,*