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Catalogue Number
AV-C10483
Analysis Method
HPLC,NMR,MS
Specification
98%
Storage
2-8°C
Molecular Weight
205.25
Appearance
Botanical Source
Structure Type
Category
Standards;Natural Pytochemical;API
SMILES
C1=CC=C(C=C1)C2=NC3=CC=CC=C3C=C2
Synonyms
Phenylquinoline/2-Phenylquinoline/2-phenyl quinoline/Quinoline, 2-phenyl-/EINECS 210-326-7/a-Phenylquinoline
IUPAC Name
2-phenylquinoline
Applications
Density
1.1±0.1 g/cm3
Solubility
2-phenylquinoline; Galipea longiflora; Gastric secretion; Gastric ulcer; Gastrin; Histamine
Flash Point
159.1±11.9 °C
Boiling Point
363.0±11.0 °C at 760 mmHg
Melting Point
84-85 °C(lit.)
InChl
InChl Key
WGK Germany
RID/ADR
HS Code Reference
2933490000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:612-96-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
28190472
BACKGROUND:
We previously described the gastroprotective effect of 2-phenylquinoline (2-PQ), the main alkaloid isolated from the bark of Galipea longiflora (Rutaceae). However, despite the significant and promising results, the pharmacological mechanisms of the gastroprotection induced by 2-PQ have not been investigated.
PURPOSE:
To evaluate the mechanisms underlying the gastroprotective effects of 2-PQ.
STUDY DESIGN:
We used an in vivo mouse ulcer model and in vitro methodologies involving H?/K?-ATPase and L929 murine fibroblasts.
METHODS:
The gastroprotective activity of 2-PQ (10-100 mg/kg, orally, p.o) was assessed against gastric ulcer induced by 60% ethanol/0.03 M hydrochloric acid (HCl) in mice or that induced by indomethacin (80 mg/kg, p.o) in rats. The cytotoxicity was assessed in L929 murine fibroblasts. Ulcerated tissues were analyzed histologically, histochemically, and biochemically. The antisecretory activity of 2-PQ was evaluated in vivo and in vitro.
RESULTS:
2-PQ showed no cytotoxicity, reduced the lesion area induced by ethanol/HCl (log half-maximal effective dose, ED50 = 1.507), and the histological evaluation supported these results. Furthermore, 2-PQ reduced indomethacin-induced gastric ulceration. The gastroprotection was accompanied by normalization of superoxide dismutase (SOD) and glutathione-S-transferase (GST) activity, an intense increase in reduced glutathione (GSH) levels, and reduction in lipid peroxide (LPO) and tumor necrosis factor (TNF)-α levels in the gastric mucosa. The antisecretory properties of 2-PQ were confirmed by the decreased volume and total acidity of the gastric juice, and it reduced histamine- or pentagastrin-stimulated gastric acid secretion. However, 2-PQ did not change the in vitro H?/K?-ATPase activity or the content of gastric-adhered mucous in mice. In addition, pretreatment with N-ethylmaleimide, NG-nitro-l-arginine methyl esters, yohimbine, or indomethacin reversed the gastroprotective effect of 2-PQ, suggesting nitric oxide, nonprotein sulfhydryl compounds, α-2-receptors, and prostaglandin were involved.
CONCLUSION:
2-PQ provides gastroprotection by reducing oxidative damage and inhibiting acid secretion mediated by histaminergic and gastrinergic regulatory pathways.
Copyright ? 2016 Elsevier GmbH. All rights reserved.
2-phenylquinoline; Galipea longiflora; Gastric secretion; Gastric ulcer; Gastrin; Histamine
Gastroprotective and anti-secretory mechanisms of 2-phenylquinoline, an alkaloid isolated from Galipea longiflora.
Breviglieri E1, Mota da Silva L1, Boeing T1, Somensi LB1, Cury BJ1, Gimenez A2, Cechinel Filho V1, de Andrade SF3.
2017 Feb 15