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2-Phenylquinoline

$183

  • Brand : BIOFRON

  • Catalogue Number : BN-O1723

  • Specification : 98%(HPLC)

  • CAS number : 612-96-4

  • Formula : C15H11N

  • Molecular Weight : 205.25

  • PUBCHEM ID : 71545

  • Volume : 1g

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Catalogue Number

BN-O1723

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

205.25

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC=C(C=C1)C2=NC3=CC=CC=C3C=C2

Synonyms

Phenylquinoline/2-Phenylquinoline/2-phenyl quinoline/Quinoline, 2-phenyl-/EINECS 210-326-7/a-Phenylquinoline

IUPAC Name

2-phenylquinoline

Density

1.1±0.1 g/cm3

Solubility

Flash Point

159.1±11.9 °C

Boiling Point

363.0±11.0 °C at 760 mmHg

Melting Point

84-85 °C(lit.)

InChl

InChl Key

FSEXLNMNADBYJU-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:612-96-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28190472

Abstract

BACKGROUND:
We previously described the gastroprotective effect of 2-phenylquinoline (2-PQ), the main alkaloid isolated from the bark of Galipea longiflora (Rutaceae). However, despite the significant and promising results, the pharmacological mechanisms of the gastroprotection induced by 2-PQ have not been investigated.

PURPOSE:
To evaluate the mechanisms underlying the gastroprotective effects of 2-PQ.

STUDY DESIGN:
We used an in vivo mouse ulcer model and in vitro methodologies involving H⁺/K⁺-ATPase and L929 murine fibroblasts.

METHODS:
The gastroprotective activity of 2-PQ (10-100 mg/kg, orally, p.o) was assessed against gastric ulcer induced by 60% ethanol/0.03 M hydrochloric acid (HCl) in mice or that induced by indomethacin (80 mg/kg, p.o) in rats. The cytotoxicity was assessed in L929 murine fibroblasts. Ulcerated tissues were analyzed histologically, histochemically, and biochemically. The antisecretory activity of 2-PQ was evaluated in vivo and in vitro.

RESULTS:
2-PQ showed no cytotoxicity, reduced the lesion area induced by ethanol/HCl (log half-maximal effective dose, ED50 = 1.507), and the histological evaluation supported these results. Furthermore, 2-PQ reduced indomethacin-induced gastric ulceration. The gastroprotection was accompanied by normalization of superoxide dismutase (SOD) and glutathione-S-transferase (GST) activity, an intense increase in reduced glutathione (GSH) levels, and reduction in lipid peroxide (LPO) and tumor necrosis factor (TNF)-α levels in the gastric mucosa. The antisecretory properties of 2-PQ were confirmed by the decreased volume and total acidity of the gastric juice, and it reduced histamine- or pentagastrin-stimulated gastric acid secretion. However, 2-PQ did not change the in vitro H⁺/K⁺-ATPase activity or the content of gastric-adhered mucous in mice. In addition, pretreatment with N-ethylmaleimide, NG-nitro-l-arginine methyl esters, yohimbine, or indomethacin reversed the gastroprotective effect of 2-PQ, suggesting nitric oxide, nonprotein sulfhydryl compounds, α-2-receptors, and prostaglandin were involved.

CONCLUSION:
2-PQ provides gastroprotection by reducing oxidative damage and inhibiting acid secretion mediated by histaminergic and gastrinergic regulatory pathways.

Copyright © 2016 Elsevier GmbH. All rights reserved.

KEYWORDS

2-phenylquinoline; Galipea longiflora; Gastric secretion; Gastric ulcer; Gastrin; Histamine

Title

Gastroprotective and anti-secretory mechanisms of 2-phenylquinoline, an alkaloid isolated from Galipea longiflora.

Author

Breviglieri E1, Mota da Silva L1, Boeing T1, Somensi LB1, Cury BJ1, Gimenez A2, Cechinel Filho V1, de Andrade SF3.

Publish date

2017 Feb 15


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