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2,6-Bis(hydroxymethyl)-p-cresol

$58

  • Brand : BIOFRON

  • Catalogue Number : BN-O1110

  • Specification : 98%(HPLC)

  • CAS number : 91-04-3

  • Formula : C9H12O3

  • Molecular Weight : 168.19

  • PUBCHEM ID : 7039

  • Volume : 5mg

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Catalogue Number

BN-O1110

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

168.19

Appearance

Botanical Source

Structure Type

Category

SMILES

CC1=CC(=C(C(=C1)CO)O)CO

Synonyms

2,6-di(hydroxymethyl)-4-methylphenol/2,6-Bis(hydroxymethyl)-4-methylphenol/2,6-Bis(hydroxymethyl)-p-cresol/1,3-Benzenedimethanol, 2-hydroxy-5-methyl-

IUPAC Name

2,6-bis(hydroxymethyl)-4-methylphenol

Density

1.3±0.1 g/cm3

Solubility

Flash Point

166.1±13.9 °C

Boiling Point

333.3±11.0 °C at 760 mmHg

Melting Point

128-130 °C(lit.)

InChl

InChl Key

KUMMBDBTERQYCG-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:91-04-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

23672493

Abstract

Background
Cisplatin (CDDP) is the most frequently used chemotherapeutic agent for various types of advanced cancer, including gastric cancer. However, almost all cancer cells acquire resistance against CDDP, and this phenomenon adversely affects prognosis. Thus, new chemotherapeutic agents that can overcome the CDDP-resistant cancer cells will improve the survival of advanced cancer patients.

Methods
We synthesized new glycoconjugated platinum (II) and palladium (II) complexes, [PtCl2 (L)] and [PdCl2 (L)]. CDDP-resistant gastric cancer cell lines were established by continuous exposure to CDDP, and gene expression in the CDDP-resistant gastric cancer cells was analyzed. The cytotoxicity and apoptosis induced by [PtCl2 (L)] and [PdCl2 (L)] in CDDP-sensitive and CDDP-resistant gastric cancer cells were evaluated. DNA double-strand breaks by drugs were assessed by evaluating phosphorylated histone H2AX. Xenograft tumor mouse models were established and antitumor effects were also examined in vivo.

Results
CDDP-resistant gastric cancer cells exhibit ABCB1 and CDKN2A gene up-regulation, as compared with CDDP-sensitive gastric cancer cells. In the analyses of CDDP-resistant gastric cancer cells, [PdCl2 (L)] overcame cross-resistance to CDDP in vitro and in vivo. [PdCl2 (L)] induced DNA double-strand breaks.

Conclusion
These results indicate that [PdCl2 (L)] is a potent chemotherapeutic agent for CDDP-resistant gastric cancer and may have clinical applications.

KEYWORDS

Glycoconjugated platinum (II) complex, Glycoconjugated palladium (II) complex, Cisplatin, Drug resistance, Gastric cancer

Title

Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells

Author

Mamoru Tanaka,1 Hiromi Kataoka,corresponding author1 Shigenobu Yano,2,3 Hiromi Ohi,4 Keisuke Kawamoto,5 Takashi Shibahara,5 Tsutomu Mizoshita,1 Yoshinori Mori,1 Satoshi Tanida,1 Takeshi Kamiya,1 and Takashi Joh1

Publish date

2013;


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