We Offer Worldwide Shipping
Login Wishlist

3β-Hydroxyurs-11-en-28,13-olide

$1,120

  • Brand : BIOFRON

  • Catalogue Number : BN-O1471

  • Specification : 98%(HPLC)

  • CAS number : 35959-05-8

  • Formula : C30H46O3

  • Molecular Weight : 454.7

  • PUBCHEM ID : 21606663

  • Volume : 5mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BN-O1471

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

454.7

Appearance

Powder

Botanical Source

This product is isolated and purified from the leaves of Eucalyptus viminalis

Structure Type

Triterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1CCC23CCC4(C5(CCC6C(C(CCC6(C5C=CC4(C2C1C)OC3=O)C)O)(C)C)C)C

Synonyms

(3β,5ξ,9ξ,13α,17α,18ξ)-3-Hydroxy-13,28-epoxyurs-11-en-28-one/Urs-11-en-28-one, 13,28-epoxy-3-hydroxy-, (3β,5ξ,9ξ,13α,17α,18ξ)-

IUPAC Name

(1S,4S,5R,8R,10S,13S,14R,17S,18R,19S,20R)-10-hydroxy-4,5,9,9,13,19,20-heptamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-en-23-one

Density

1.1±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

212.4±22.9 °C

Boiling Point

563.1±50.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C30H46O3/c1-18-8-14-29-17-16-28(7)27(6)13-9-20-25(3,4)22(31)11-12-26(20,5)21(27)10-15-30(28,33-24(29)32)23(29)19(18)2/h10,15,18-23,31H,8-9,11-14,16-17H2,1-7H3/t18-,19+,20+,21-,22+,23-,26+,27-,28+,29+,30+/m1/s1

InChl Key

UVBLDLGZDSGCSN-RUOWOPRNSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:35959-05-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27775027

Abstract

What strategies do bacteria employ for adaptation to their hosts and are these strategies different for varied hosts? To date, many studies on the interaction of the bacterium and its host have been published. However, global changes in the bacterial cell in the process of invasion and persistence, remain poorly understood. In this study, we demonstrated phase transition of the avian pathogen Mycoplasma gallisepticum upon invasion of the various types of eukaryotic cells (human, chicken, and mouse) which was stable during several passages after isolation of intracellular clones and recultivation in a culture medium. It was shown that this phase transition is manifested in changes at the proteomic, genomic and metabolomic levels. Eukaryotic cells induced similar proteome reorganization of M. gallisepticum during infection, despite different origins of the host cell lines. Proteomic changes affected a broad range of processes including metabolism, translation and oxidative stress response. We determined that the activation of glycerol utilization, overproduction of hydrogen peroxide and the upregulation of the SpxA regulatory protein occurred during intracellular infection. We propose SpxA as an important regulator for the adaptation of M. gallisepticum to an intracellular environment.

Title

Phase Transition of the Bacterium upon Invasion of a Host Cell as a Mechanism of Adaptation: a Mycoplasma gallisepticum Model

Author

Daria Matyushkina,a,1 Olga Pobeguts,1 Ivan Butenko,1 Anna Vanyushkina,1 Nicolay Anikanov,2 Olga Bukato,1 Daria Evsyutina,1,3 Alexandra Bogomazova,4,5 Maria Lagarkova,4 Tatiana Semashko,1 Irina Garanina,1,2 Vladislav Babenko,6 Maria Vakhitova,7 Valentina Ladygina,1 Gleb Fisunov,1 and Vadim Govorun1,2,7

Publish date

2016

PMID

26988419

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal form of cancer with few therapeutic options. We found that levels of the lysine methyltransferase SMYD2 (SET and MYND domain 2) are elevated in PDAC and that genetic and pharmacological inhibition of SMYD2 restricts PDAC growth. We further identified the stress response kinase MAPKAPK3 (MK3) as a new physiologic substrate of SMYD2 in PDAC cells. Inhibition of MAPKAPK3 impedes PDAC growth, identifying a potential new kinase target in PDAC. Finally, we show that inhibition of SMYD2 cooperates with standard chemotherapy to treat PDAC cells and tumors. These findings uncover a pivotal role for SMYD2 in promoting pancreatic cancer.

KEYWORDS

Ras, SMYD2, MAPKAPK3, pancreatic cancer, lung adenocarcinoma, lysine methylation

Title

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

Author

Nicolas Reynoird, Pawel K. Mazur, Timo Stellfeld, Natasha M. Flores, Shane M. Lofgren, Scott M. Carlson, Elisabeth Brambilla, Pierre Hainaut, Ewa B. Kaznowska, Cheryl H. Arrowsmith, Purvesh Khatri, Carlo Stresemann, Or Gozani, Julien Sage

Publish date

2016 Apr 1

PMID

29673210

Abstract

The phase angle (PhA) seems to be a reliable screening tool for the identification of malnutrition risk in hospitalized children with inflammatory bowel disease (IBD). The aim of the present study was to assess the body composition and nutritional status of hospitalized children and adolescents with IBD by using bioelectrical impedance analysis (BIA) with phase angle (PhA) calculation, which has not been evaluated in hospitalized children with IBD yet. A total of 59 children and adolescents aged 4-18 years, with IBD: 34 ulcerative colitis (UC) and 25 Crohn’s disease (CD) were included in the study. The control group consisted of healthy children and adolescents, strictly matched for gender and age in a 1:1 case-control manner. In both groups, BIA was performed and PhA was calculated. IBD patients had significantly lower PhA (UC: 5.34 ± 1.34 vs. 5.96 ± 0.76, p = 0.040; CD: 5.16 ± 1.18 vs. 5.90 ± 0.62, p = 0.009) compared to the control subjects. Significant changes in selected body composition parameters were observed particularly in CD, especially in fat free mass components. Lower phase angle score together with lower body composition parameters and selected nutrition indicators in children and adolescents with IBD demonstrate their worse nutritional and functional status compared to healthy subjects.

KEYWORDS

phase angle, bioelectrical impedance, inflammatory bowel diseases, malnutrition, children

Title

Bioelectrical Impedance Phase Angle as an Indicator of Malnutrition in Hospitalized Children with Diagnosed Inflammatory Bowel Diseases—A Case Control Study

Author

Paweł Więch,1,* Mariusz Dabrowski,1,2 Dariusz Bazaliński,1 Izabela Sałacińska,1 Bartosz Korczowski,3 and Monika Binkowska-Bury1

Publish date

2018 Apr;


Description :

Empty ...