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Catalogue Number
AV-C10473
Analysis Method
HPLC,NMR,MS
Specification
98%
Storage
2-8°C
Molecular Weight
212.3
Appearance
Oil
Botanical Source
Structure Type
Sesquiterpenoids
Category
Standards;Natural Pytochemical;API
SMILES
CC1(CCC2=C(O1)C3=CC=CC=C3C=C2)C
Synonyms
w1917/2,2-Dimethyl-3,4-dihydro-2H-benzo[h]chromene/2H-Naphtho[1,2-b]pyran, 3,4-dihydro-2,2-dimethyl-
IUPAC Name
2,2-dimethyl-3,4-dihydrobenzo[h]chromene
Applications
Density
1.1±0.1 g/cm3
Solubility
Flash Point
152.6±15.3 °C
Boiling Point
334.7±12.0 °C at 760 mmHg
Melting Point
InChl
InChl Key
HYUYQZUDUFSJRS-UHFFFAOYSA-N
WGK Germany
RID/ADR
HS Code Reference
2902900000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:16274-33-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
18227145
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501) is a fully synthetic version of the natural product beta-lapachone, which has been isolated from the lapacho tree (Tabebuia impetiginosa or Tabebuia avellanedae) and has demonstrated promising anticancer activity. ARQ 501 formulated with hydroxypropyl-beta-cyclodextrin has successfully completed phase I clinical trials and is currently in several phase II human clinical trials for the treatment of pancreatic cancer, head and neck cancer, and leiomyosarcoma. The metabolites of ARQ 501 were investigated by low-resolution and high-resolution mass spectrometry in plasma from (nu/nu) mice, rats, and humans treated with the compound. The data for one of the metabolites identified are consistent with conjugation of ARQ 501 with a glucosylsulfate moiety (m/z 241; fragment ion). Although other glucosylsulfate conjugates have been identified as metabolites of pesticides in cotton plants and in crustaceans as phase II metabolites of pyrenes, none have been previously identified in mammals. Data reported here identify a novel metabolic pathway for humans.
Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals.
Savage RE1, Tyler AN, Miao XS, Chan TC.
2008 Apr
