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3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran

$1,120

  • Brand : BIOFRON

  • Catalogue Number : BN-O1715

  • Specification : 98%(HPLC)

  • CAS number : 16274-33-2

  • Formula : C15H16O

  • Molecular Weight : 212.3

  • PUBCHEM ID : 11052973

  • Volume : 5mg

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Catalogue Number

BN-O1715

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

212.3

Appearance

Oil

Botanical Source

This product is isolated and purified from the roots of Galium saxatile.

Structure Type

Category

SMILES

CC1(CCC2=C(O1)C3=CC=CC=C3C=C2)C

Synonyms

w1917/2,2-Dimethyl-3,4-dihydro-2H-benzo[h]chromene/2H-Naphtho[1,2-b]pyran, 3,4-dihydro-2,2-dimethyl-

IUPAC Name

Density

1.1±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

152.6±15.3 °C

Boiling Point

334.7±12.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

HYUYQZUDUFSJRS-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:16274-33-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

18227145

Abstract

3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501) is a fully synthetic version of the natural product beta-lapachone, which has been isolated from the lapacho tree (Tabebuia impetiginosa or Tabebuia avellanedae) and has demonstrated promising anticancer activity. ARQ 501 formulated with hydroxypropyl-beta-cyclodextrin has successfully completed phase I clinical trials and is currently in several phase II human clinical trials for the treatment of pancreatic cancer, head and neck cancer, and leiomyosarcoma. The metabolites of ARQ 501 were investigated by low-resolution and high-resolution mass spectrometry in plasma from (nu/nu) mice, rats, and humans treated with the compound. The data for one of the metabolites identified are consistent with conjugation of ARQ 501 with a glucosylsulfate moiety (m/z 241; fragment ion). Although other glucosylsulfate conjugates have been identified as metabolites of pesticides in cotton plants and in crustaceans as phase II metabolites of pyrenes, none have been previously identified in mammals. Data reported here identify a novel metabolic pathway for humans.

Title

Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals.

Author

Savage RE1, Tyler AN, Miao XS, Chan TC.

Publish date

2008 Apr


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