We Offer Worldwide Shipping
Login Wishlist

3-Amino-3-phenyl-1-propanol

$72

  • Brand : BIOFRON

  • Catalogue Number : BN-O1193

  • Specification : 98%(HPLC)

  • CAS number : 14593-04-5

  • Formula : C9H13NO

  • Molecular Weight : 151.21

  • Volume : 5mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BN-O1193

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

151.21

Appearance

Botanical Source

Structure Type

Category

SMILES

C1=CC=C(C=C1)C(CCO)N

Synonyms

3-Amino-3-phenyl-1-propanol/3-Amino-3-phenyl-propan-1-ol/Benzenepropanol, γ-amino-/3-amino-3-phenylpropan-1-ol

IUPAC Name

Density

1.1±0.1 g/cm3

Solubility

Flash Point

131.0±21.8 °C

Boiling Point

293.0±20.0 °C at 760 mmHg

Melting Point

70-77ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:14593-04-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29109410

Abstract

Current research on the influence of environmental and physicochemical factors in shaping the soil bacterial structure has seldom been approached from a pedological perspective. We studied the bacterial communities of eight soils selected along a pedogenic gradient at the local scale in a Mediterranean calcareous mountain (Sierra de Maria, SE Spain). The results showed that the relative abundance of Acidobacteria, Canditate division WPS-1, and Armatimonadetes decreased whereas that of Actinobacteria, Bacteroidetes, and Proteobacteria increased from the less-developed soils (Leptosol) to more-developed soils (Luvisol). This bacterial distribution pattern was also positively correlated with soil-quality parameters such as organic C, water-stable aggregates, porosity, moisture, and acidity. In addition, at a lower taxonomic level, the abundance of Acidobacteria Gp4, Armatimonadetes_gp4, Solirubrobacter, Microvirga, Terrimonas, and Nocardioides paralleled soil development and quality. Therefore, our work indicates that the composition of bacterial populations changes with pedogenesis, which could be considered a factor influencing the communities according to the environmental and physicochemical conditions during the soil formation.

Title

Changes in the soil bacterial community along a pedogenic gradient

Author

Manuel Sanchez-MaraNon,#1 Isabel Miralles,#2 Jose F. Aguirre-Garrido,3 Manuel Anguita-Maeso,2,4 Vicenta Millan,5 Raul Ortega,2 Jose A. Garcia-Salcedo,4,6 Francisco Martinez-Abarca,corresponding author5 and Miguel Sorianocorresponding author2,4

Publish date

2017

PMID

28099934

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are being tested extensively for their role in the treatment and prevention of several cancers. Typically NSAIDs exhibit anti-tumor activities via modulation of cyclooxygenase (COX)-dependent mechanisms, however, an anti-cancer NSAID tolfenamic acid (TA) is believed to work through COX-independent pathways. Results from our laboratory and others have demonstrated the anti-cancer activity of TA in various cancer models including pancreatic cancer. TA has been shown to modulate certain cellular processes including, apoptosis, reactive oxygen species and signaling. In this study, molecular profiling was performed to precisely understand the mode of action of TA. Three pancreatic cancer cell lines, L3.6pl, MIA PaCa-2, and Panc1 were treated with TA (50 μM for 48 h) and the changes in gene expression was evaluated using the Affymetrix GeneChip Human Gene ST Array platform. Microarray results were further validated using quantitative PCR for seven genes altered by TA treatment in all three cell lines. Functional analysis of differentially expressed genes (2 fold increase or decrease, p < 0.05) using Ingenuity Pathway Analysis software, revealed that TA treatment predominantly affected the genes involved in cell cycle, cell growth and proliferation, and cell death and survival. Promoter analysis of the differentially expressed genes revealed that they are enriched for Sp1 binding sites, suggesting that Sp1 could be a major contributor in mediating the effect of TA. The gene expression studies identified new targets involved in TA's mode of action, while supporting the hypothesis about the association of Sp1 in TA mediated effects in pancreatic cancer.

KEYWORDS

tolfenamic acid, pancreatic cancer, Sp1, microarray analysis

Title

Tolfenamic acid-induced alterations in genes and pathways in pancreatic cancer cells

Author

Umesh T. Sankpal,1 Steve Goodison,2 Michelle Jones-Pauley,1 Myrna Hurtado,3 Fan Zhang,3 and Riyaz Basha1,3

Publish date

2017 Feb 28

PMID

19706546

Abstract

Corticotropin-releasing factor (CRF), encoded by the CRH gene, is a key integrator of stress responses, and, as such, CRH gene variation may contribute to individual differences in susceptibility to stress-related pathology. In rhesus macaques, a single nucleotide polymorphism (SNP) is found within the CRH promoter (−248C→ T). Here, we assessed whether this variant influenced stress responding and, because increased CRF system activity drives alcohol drinking in rodents, we examined whether it predicted voluntary alcohol consumption as a function of prior stress exposure. Using a hypothalamic nuclear extract, we showed that the −248 T allele resulted in increased DNA protein interactions relative to the C allele. In vitro, the T allele resulted in CRH promoter activity that was higher following both stimulation with forskolin and treatment with dexamethasone. Endocrine and behavioral responses to social separation stress (release of ACTH and cortisol, and suppression of environmental exploration, respectively) were higher among carriers of the T allele, particularly among those exposed to early adversity in the form of peer rearing. We also found that T allele carriers with a history of early life adversity consumed more alcohol in a limited-access paradigm. Our data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals.

KEYWORDS

corticotropin-releasing factor, CRH promoter

Title

Functional CRH variation increases stress-induced alcohol consumption in primates

Author

Christina S. Barr,a,1,2 Rachel L. Dvoskin,a,1 Manisha Gupte,a,b Wolfgang Sommer,a Hui Sun,a Melanie L. Schwandt,a Stephen G. Lindell,a John W. Kasckow,c Stephen J. Suomi,d,1 David Goldman,b,1 J. Dee Higley,e,1 and Markus Heiliga,1

Publish date

2009 Aug 25;


Description :

Empty ...