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3-Amino-4-methylbenzamide

$58

  • Brand : BIOFRON

  • Catalogue Number : BN-O1168

  • Specification : 98%(HPLC)

  • CAS number : 19406-86-1

  • Formula : C8H10N2O

  • Molecular Weight : 150.18

  • PUBCHEM ID : 88043

  • Volume : 5mg

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Catalogue Number

BN-O1168

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

150.18

Appearance

Botanical Source

Structure Type

Category

SMILES

CC1=C(C=C(C=C1)C(=O)N)N

Synonyms

IUPAC Name

3-amino-4-methylbenzamide

Density

1.185 g/cm3

Solubility

Flash Point

137.6ºC

Boiling Point

304ºC at 760 mmHg

Melting Point

127-131 °C(lit.)

InChl

InChl Key

VYBKAZXQKUFAHG-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:19406-86-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27146949

Abstract

The aim of this study was the optimisation of a multi-analyte method for the analysis of primary aromatic amines (PAAs) from napkins in order to support official controls and food safety. We developed a UHPLC-MS/MS method for the simultaneous determination of 36 toxicologically relevant PAAs for paper and board. Good regression coefficients of the calibration curves in a range of 0.992-0.999 and reproducibilities in a range of 2.3-15% were obtained. Limits of detections (LODs) were in the range of 0.03-1.4 µg l-1 and recoveries were in a range of 21-110% for all the amines. A total of 93 coloured paper napkin samples from different European countries were bought and extracted with water to determine the PAAs. The results showed that 42 of 93 samples contained at least one PAA. More than half of the detected PAAs are considered as toxic, carcinogenic or probably carcinogenic to humans by the International Agency for Research on Cancer (IARC), or are classified as such in the European Union legislation on chemicals. Summed concentrations of PAAs in seven samples were higher than 10 µg l-1, the limit of summed PAA in the European Union plastic food contact material regulation. Also, eight PAAs, classified as Category 1A and 1B carcinogen in the European Union legislation of chemicals, were detected at concentrations higher than 2 µg l-1, exceeding the limit proposed by the Federal Institute for Risk Assessment in Germany. Aniline (n = 14) was most frequently present in higher concentrations followed by o-toluidine, o-anisidine, 2,4-dimethylaniline and 4-aminoazobenzene. Red, orange, yellow and multicoloured paper napkins contained the highest concentrations of total PAAs (> 10 µg l-1). Although the European Union has not harmonised the legislation of paper and board materials and, thus, there is no specific migration limit for PAAs from paper napkins, the present study showed that coloured paper napkins can contain toxic and carcinogenic PAAs at concentrations that are relevant for monitoring.

KEYWORDS

Primary aromatic amines (PAAs), paper napkins, cold water extract, UHPLC-MS/MS

Title

Determination of primary aromatic amines in cold water extract of coloured paper napkin samples by liquid chromatography-tandem mass spectrometry

Author

Oguzhan Yavuz, a , * Sandro Valzacchi, a Eddo Hoekstra, a , * and Catherine Simoneau a

Publish date

2016 Jun 1.


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