1(3H)-Isobenzofuranone, 3-(phenylmethylene)-, (3E)-/(3E)-3-Benzylidene-2-benzofuran-1(3H)-one/3-Benzylidenphthalide/benzalphthalide
374.1±42.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:575-61-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Identification and Quantitation of a 3-benzylidenephthalide Contaminant of Phenindione Tablets and Its Characterization as a Potentially Immunogenic Substance
A straightforward synthetic method for the preparation of isocoumarins and 3-benzylidenephthalides via C-H olefination and oxidative coupling of readily available benzoic acids and vinylarenes was developed. The directing effect of the substituents on the benzoic acid allows for the synthesis of both types of lactone in pure form.
One-step Synthesis of Isocoumarins and 3-benzylidenephthalides via Ligandless Pd-catalyzed Oxidative Coupling of Benzoic Acids and Vinylarenes
Debkumar Nandi 1, Debalina Ghosh, Shih-Ji Chen, Bing-Chiuan Kuo, Nancy M Wang, Hon Man Lee
2013 Apr 5
To evaluate discrepancies prevalent between self-reported hearing difficulty (SHD) and audiometrically measured hearing loss (AHL) and factors associated with such discrepancies.
Nationwide cross-sectional survey.
Data from 2010 to 2012 Korea National Health and Nutrition Examination Survey conducted by the Korea Centers for Disease Control and Prevention.
We included 14 345 participants aged ≥19 years who had normal tympanic membranes (mean age of 49 years).
Self-reported hearing was assessed by asking participants whether they had difficulty in hearing. AHL was defined as >25 dB of mean hearing thresholds measured at 0.5, 1, 2 and 4 kHz in better ear. Underestimated hearing impairment (HI) was defined as having AHL without SHD. Likewise, overestimated HI was defined as having SHD without AHL. Prevalence of underestimated and overestimated HIs was determined. Univariable and multivariable analyses were performed to examine factors associated with such discrepancies compared with concordant HL.
Among 14 345 participants, 1876 (13.1%) had underestimated HI while 733 (5.1%) had overestimated HI. Multivariable models revealed that participants who had discrepancies between SHD and AHL were less likely to have older age (OR: 0.979, 95% CI: 0.967 to 0.991 for the underestimated HI, OR: 0.905, 95% CI: 0.890 to 0.921 for the overestimated HI) and tinnitus (OR: 0.425, 95% CI: 0.344 to 0.525 for the underestimated HI and OR 0.523, 95% CI: 0.391 to 0.699 for the overestimated HI) compared with those who had concordant HI. Exposure to occupational noise (OR: 0.566, 95% CI: 0.423 to 0.758) was associated with underestimated HI, and medical history of hypertension (OR: 1.501, 95% CI: 1.061 to 2.123) and depression (OR: 1.771, 95% CI: 1.041 to 3.016) was associated with overestimated HI.
Age, tinnitus, occupational noise exposure, hypertension and depression should be incorporated into evaluation of hearing loss in clinical practice.
Self-reported hearing difficulty, prevalence, National Health and Nutrition Examination Survey, audiometry
Discrepancies between self-reported hearing difficulty and hearing loss diagnosed by audiometry: prevalence and associated factors in a national survey
Ji Eun Choi,#1 Il Joon Moon,#2 Sun-Young Baek,3 Seon Woo Kim,3 and Yang-Sun Cho2