Catalogue Number
2930900000
Analysis Method
Specification
Congchong Wu 1, Xingyang Chen 2, Jianbo Lai 1 3 4, Yi Xu 1 3 4, Shaohua Hu 1 3 4
Storage
Inhibitory effects of phytochemicals on NLRP3 inflammasome activation: A review
Molecular Weight
32590809
Appearance
Melis Olcum 1, Bora Tastan 2, Ilkcan Ercan 2, Irem B Eltutan 2, Sermin Genc 3
Botanical Source
32445760
Structure Type
Aims: Skeletal muscle diseases have become to be the most common complication in patients with type 2 diabetic mellitus (T2DM). However, the effective therapies against skeletal muscle diseases are not yet available. Sulforaphane (SFN) is an organic isothiocyanate found in cruciferous plants. Our aim was to explore whether SFN could attenuate the skeletal muscle diseases in spontaneous type 2 diabetic db/db mice. Materials and methods: The db/m and littermate db/db mice were treated with SFN or dimethyl sulfoxide. The grip strength of mice was measured by a grasping forcing machine. The electron transmission microscopy was used to perform the skeletal muscle. The western blot was used to detect the nuclear factor E2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) signal pathway related proteins, and inflammatory and apoptotic associated proteins. The mRNA levels of anti-inflammatory and anti-oxidative relative genes were detected by RT-QPCR. Key findings: We found that SFN could significantly increase the grip strength of the db/db mice. The lean mass and gastrocnemius mass were increased in the db/db mice after administration with SFN. Additionally, the db/db mice restored the skeletal muscle fiber organization after SFN treatment. Mechanistically, SFN could activate the Nrf2/HO-1 signal pathway, and downregulate the expression of inflammatory and apoptotic associated proteins. Furthermore, SFN could also regulate the mRNA levels of anti-inflammatory and anti-oxidative related genes. Significance: Our results demonstrated that SFN can protect against skeletal muscle diseases in db/db type 2 diabetic mice and provide a potential drug to prevent skeletal muscle dysfunction in T2DM patients.
Category
2020 Aug 15
SMILES
Synonyms
IUPAC Name
2020 Aug 15
Density
Solubility
Flash Point
Boiling Point
Melting Point
InChl
PS1868-0050
InChl Key
WGK Germany
RID/ADR
HS Code Reference
Personal Projective Equipment
Correct Usage
Meta Tag
2020 Jun 26
No Technical Documents Available For This Product.
No Article Available.
Description :
Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic db/db mice