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3,29-Dibenzoyl rarounitriol

$560

  • Brand : BIOFRON

  • Catalogue Number : BD-P0261

  • Specification : 98.0%(HPLC)

  • CAS number : 873001-54-8

  • PUBCHEM ID : 11556558

  • Volume : 25mg

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Catalogue Number

BD-P0261

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

Appearance

White crystal

Botanical Source

Trichosanthes kirilowii Maxim./Cucumis melo var. inodorus (melon) and Trichosanthes kirilowii

Structure Type

Triterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C(CCC2(C1CC(C3=C2CCC4(C3(CCC5(C4CC(CC5)(C)COC(=O)C6=CC=CC=C6)C)C)C)O)C)OC(=O)C7=CC=CC=C7)C

Synonyms

[(2R,4aS,6aS,7S,8aR,10R,12aS,14aS,14bR)-10-(Benzoyloxy)-7-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,2,3,4,4a,5,6,6a,7,8,8a,9,10,11,12,12a,13,14,14a,14b-icosahydro-2-picenyl]methyl benzoate/3,6-Picenediol, 11-[(benzoyloxy)methyl]-1,2,3,4,4a,5,6,6b,7,8,8a,9,10,11,12,12a,12b,13,14,14b-eicosahydro-4,4,6b,8a,11,12b,14b-heptamethyl-, 3-benzoate, (3R,4aR,6S,6bS,8aS,11R,12aR,12bS,14bS)-

IUPAC Name

[(2R,4aS,6aS,7S,8aR,10R,12aS,14aS,14bR)-10-benzoyloxy-7-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,13,14,14b-tetradecahydropicen-2-yl]methyl benzoate

Applications

3,29-Dibenzoyl rarounitriol is one major bioactive compound of multiflorane triterpene esters Trichosanthes kirilowii, can be chosen as the marker for quantitation of Trichosanthes kirilowii[1].

Density

1.2±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate; Dichloromethane

Flash Point

203.9±26.4 °C

Boiling Point

706.5±60.0 °C at 760 mmHg

Melting Point

162-164ºC

InChl

InChI=1S/C44H58O5/c1-39(2)33-26-32(45)36-31(42(33,5)20-19-35(39)49-38(47)30-16-12-9-13-17-30)18-21-43(6)34-27-40(3,22-23-41(34,4)24-25-44(36,43)7)28-48-37(46)29-14-10-8-11-15-29/h8-17,32-35,45H,18-28H2,1-7H3/t32-,33-,34+,35+,40+,41+,42+,43-,44+/m0/s1

InChl Key

ZRKGVMOZKMBTHF-DUVCPVCPSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:873001-54-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

25611485

Abstract

A rapid, sensitive and high-throughput liquid chromatography-tandem mass spectrometry was established and validated to assay the concentrations of 3,29-dibenzoyl rarounitriol in rat plasma. Plasma samples were processed by liquid-liquid extraction with ethyl acetate and separated on a Hypersil Gold C18 column (50 × 4.6 mm, 3 µm) at an isocratic flow rate of 0.5 mL/min using methanol-10 mm ammonium acetate-formic acid (90:10:0.1, v/v/v) as mobile phase. The total run time was 5 min for each sample. MS/MS detection was accomplished in selected reaction monitoring mode with positive electrospray ionization. The calibration curve was linear over the concentration range of 0.125-50 ng/mL with lower limit of quantification of 0.125 ng/mL. The intra- and inter-day precisions were <10.1% in terms of coefficient of variation, and the accuracy was within ±11.7% in terms of relative error. The developed method was successfully applied to a pharmacokinetic study of 3,29-dibenzoyl rarounitriol following intragastric administration of 3.65 mg/kg to Wistar rats. Copyright © 2015 John Wiley & Sons, Ltd.

KEYWORDS

3,29-dibenzoyl rarounitriol; Trichosanthes kirilowii; multiflorane triterpene esters; pharmacokinetics; rat plasma

Title

A rapid and sensitive LC-MS/MS method for quantification of 3,29-dibenzoyl rarounitriol in rat plasma: application to a pharmacokinetic study.

Author

Zhao C1,2, Zhang N3, Chen B2, Song Y2, Zhu N2, Zhao L2, Liu C4, Meng X1.

Publish date

2015 Aug

PMID

25345128

Abstract

OBJECTIVE:
To study the different mature stages and the best processing methods on the quality of Trichosanthes kirilowii seeds.

METHODS:
The content of 3,29-dibenzoyl rarounitriol in Trichosanthes kirilowii seeds was determined by HPLC. The sample of different mature stages such as immature, near mature and fully mature and processed by different methods were studied.

RESULTS:
Fully mature Trichosanthes kirilowii seeds were better than the immatured, and the best processing method was dried under 60degrees C, the content of 3,29-dibenzoyl rarounitriol reached up to 131.63microlg/mL.

CONCLUSION:
Different processing methods and different mature stages had a significant influence on the quality of Trichosanthes kirilowii seeds.

Title

[Influence of different processing methods and mature stages on 3,29-dibenzoyl rarounitriol of Trichosanthes kirilowii seeds].

Author

Liu JN, Xie XL, Yang TX, Zhang CL, Jia DS, Liu M, Wen CX.

Publish date

2014 Apr