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3,9-Bis(2-cyanoethyl)-2,4,8,10-tetraoxaspiro[5.5]undecane

$63

  • Brand : BIOFRON

  • Catalogue Number : BN-O1109

  • Specification : 98%(HPLC)

  • CAS number : 3058-04-6

  • Formula : C13H18N2O4

  • Molecular Weight : 266.29

  • Volume : 5mg

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Catalogue Number

BN-O1109

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

266.29

Appearance

Botanical Source

Structure Type

Category

SMILES

C1C2(COC(O1)CCC#N)COC(OC2)CCC#N

Synonyms

3,9-bis-(2-cyan-ethyl)-2,4,8,10-tetraoxa-spiro<5,5>undecan/3,9-Bis-(2-cyan-aethyl)-2,4,8,10-tetraoxa-spiro[5.5]undecan/CTU/Biscyanoethyltetraoxaspiro/2,4,8,10-Tetraoxaspiro[5.5]undecane-3,9-bis(propiononitrile)/3-[9-(2-cyanoethyl)-2,4,8,10-tetraoxaspiro[5.5]undecan-3-yl]propionitrile/3-[9-(2-cyanoethyl)-2,4,8,10-tetraoxaspiro[5.5]undecan-3-yl]propanenitrile/2,4,8,10-Tetraoxaspiro[5.5]undecane-3,9-dipropanenitrile/3,9-bis-(2-cyano-ethyl)-2,4,8,10-tetraoxa-spiro[5.5]undecane/2,4,8,10-Tetraoxaspiro[5.5]undecane-3,9-dipropionitrile/3,8-Bis-<2-cyanaethyl>-2,4,7,9-tetraoxospiro<5,5>undecan/Biscyanoethylteraoxaspiro/2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-dipropiononitrile

IUPAC Name

Density

1.21g/cm3

Solubility

Flash Point

201.5ºC

Boiling Point

492.3ºC at 760mmHg

Melting Point

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:3058-04-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27348585

Abstract

The nonsense-mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors

Title

The nonsense-mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors

Author

JingWei Lu,1,2 Terra-Dawn Plank,3 Fang Su,4 XiuJuan Shi,1 Chen Liu,5 Yuan Ji,6 ShuaiJun Li,1 Andrew Huynh,3 Chao Shi,4 Bo Zhu,4 Guang Yang,1 YanMing Wu,1 Miles F. Wilkinson,3,7 and YanJun Lu1

Publish date

2016 Aug 1;

PMID

4562752

Abstract

Methanol stimulates the hydrolysis of GTP catalyzed by bacterial ribosomes in the presence of the chain elongation factor T (EF-T). The methanol-stimulated activity is uncoupled from aminoacyl-tRNA binding to the ribosomes and does not require the presence of either synthetic polynucleotide messenger or aminoacyl-tRNA. When these reactants are present, along with EF-T, GTP, and methanol, the ribosomal binding of aminoacyl-tRNA is inhibited by thiostrepton but the uncoupled, EF-T-dependent hydrolysis of GTP is resistant to the antibiotic.

Title

Elongation Factor T-Dependent Hydrolysis of Guanosine Triphosphate Resistant to Thiostrepton

Author

Juan P. G. Ballesta and David Vazquez

Publish date

1972 Oct;

PMID

7760802

Abstract

The beta receptor for platelet-derived growth factor (beta PDGFR) is activated by binding of PDGF and undergoes phosphorylation at multiple tyrosine residues. The tyrosine-phosphorylated receptor associates with numerous SH2-domain-containing proteins which include phospholipase C-gamma 1 (PLC gamma), the GTPase-activating protein of Ras (GAP), the p85 subunit of phosphatidylinositol 3 kinase (PI3K), the phosphotyrosine phosphatase Syp, and several other proteins. Our previous studies indicated that PI3K and PLC gamma were required for relay of the mitogenic signal of beta PDGFR, whereas GAP and Syp did not appear to be required for this response. In this study, we further investigated the role of GAP and Syp in mitogenic signaling by beta PDGFR. Focusing on the PLC gamma-dependent branch of beta PDGFR signaling, we constructed a series of mutant beta PDGFRs that contained the binding sites for pairs of the receptor-associated proteins: PLC gamma and PI3K, PLC gamma and GAP, or PLC gamma and Syp. Characterization of these mutants showed that while all receptors were catalytically active and bound similar amounts of PLC gamma, they differed dramatically in their ability to initiate DNA synthesis. This signaling deficiency related to an inability to efficiently tyrosine phosphorylate and activate PLC gamma. Surprisingly, the crippled receptor was the one that recruited PLC gamma and GAP. Thus, GAP functions to suppress signal relay by the beta PDGFR, and it does so by silencing PLC gamma. These findings demonstrate that the biological response to PDGF depends not only on the ability of the beta PDGFR to recruit signal relay enzymes but also on the blend of these receptor-associated proteins.

Title

The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.

Author

M Valius, J P Secrist, and A Kazlauskas

Publish date

1995 Jun;


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