Colorless needle crystal
Rubus chingii Hu/" Isol. from raspberries (Rubus idaeus), rhubarb (Rheum spp.), European cranberry (Vaccinium oxycoccus), blackberry, loganberry and redcurrants"
Oxyphenalon/4-hydroxy benzyl acetone/Raspberry keton/4-(4-Hydroxyphenyl)-2-butanone/Frambinone/Rheosmin/OXYPHENONE/OXYPHENYLON/Raspberry ketone/EINECS 226-806-4/RASBERRY KETONE/p-Hydroxy benzylacetone/OXANONE
292.2±15.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:5471-51-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Raspberry ketone is an important ingredient in the flavor and fragrance industries. Due to its low content in fruits and vegetables, the production of natural raspberry ketone using heterologous synthesis in microbial strains is recently attracting increased attention. In this work, a heterologous pathway to produce raspberry ketone from p-coumaric acid, including 4-coumarate: CoA ligase (4CL), benzalacetone synthase (BAS), and raspberry ketone/zingerone synthase (RZS1) from plants, was successfully assembled in Escherichia coli. When the RZS1 gene was introduced into E. coli and co-expressed with two other genes, the intermediate 4-hydroxybenzylidene acetone in the pathway was almost completely transformed into a raspberry ketone. Substituting TB medium for M9 medium increased raspberry ketone titers by 3-4 times. Furthermore, the heterologous pathway was partitioned into two modules; module one produced p-coumaroyl-CoA from p-coumaric acid by 4CL, and module two produced raspberry ketone from coumaroyl-CoA by the action of BAS and RZS1. Optimizing the balanced expression of the two modules, it was shown that moderate expression of module one and high expression of module two was the best combination to enhance raspberry ketone production. The engineered strain CZ-8 reached 90.97 mg/l of raspberry ketone, which was 12 times higher than previously reported. In addition, the preferred approach of the heterologous pathway was related to the heterologous genes from different sources; for example, 4CL from Arabidopsis thaliana seemed to be more suitable for raspberry ketone production than that from Petroselinum crispum. This work paves an alternative way for future economic production of natural raspberry ketone.
4-Coumarate: CoA ligase; Benzalacetone synthase; Pathway optimization; Raspberry ketone; Raspberry ketone/zingerone synthase; p-Coumaric acid
Construction of synthetic pathways for raspberry ketone production in engineered Escherichia coli.
Wang C1, Zheng P2, Chen P1.
Obesity is a proven risk factor for neurodegenerative disease like Alzheimer’s disease (AD). Accumulating evidences suggested that nutritional interventions provide potential for prevention and treatment of AD. The present study aimed to investigate the effect of dietary treatment of obese rats with natural Raspberry ketone (RK) and their relationship with neurodegeneration. Obesity was first induced in 40 male Wistar rats (140-160 g) by feeding high fat diet (HFD) for 16 weeks. Obese rats were then assigned into 4 groups (n = 10 each). (O-AD) is obese induced AD group maintained on HFD for another 6 weeks. OCR is obese group received calorie restricted diet for 6 weeks. OCRRK is obese group received calorie restricted diet and RK (44 mg/kg body weight, daily, orally) for 6 weeks and OCRD is obese group received calorie restricted diet and orlistate (10 mg/kg body weight, daily orally) for 6 weeks. Another 10 normal rats received normal diet were used as normal control group (NC). Body weight, visceral white adipose tissue weight (WAT), lipid profile, oxidative stress markers, adiponectin, cholinergic activity and amyloid extracellular plaques were examined. In addition to histological changes in brain tissues were evaluated.Raspberry ketone (RK) via its antioxidant properties attenuated oxidative damage and dyslipidemia in O-AD group. It inhibited acetylcholinesterase enzyme (AchE) and hence increased acetylcholine level (Ach) in brain tissues of O-AD rats. It is also impeded the upregulation of beta-secretase-1 (BACE-1) and the accumulation of amyloid beta (Aβ) plaques which crucially involved in AD. The combination of CR diet with RK was more effective than CR diet with orlistate (antiobese drug) in abrogating the neurodegenerative changes induced by obesity. Results from this study suggested that concomitant supplementation of RK with calorie restricted regimen effectively modulate the neurodegenerative changes induced by obesity and delay the progression of AD.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.
Alzheimer's disease; Amyloid plaques; BACE-1; Cholinergic activity; Orlistate; Raspberry ketone
Raspberry ketone preserved cholinergic activity and antioxidant defense in obesity induced Alzheimer disease in rats.
Mohamed HE1, Abo-ELmatty DM2, Mesbah NM2, Saleh SM2, Ali AA3, Sakr AT4.
Raspberry ketone ingestion in dogs.
MacCallum R1, Bates N2, Edwards N2.
2017 Jan 7