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4-Amino-N-methylbenzamide

$63

  • Brand : BIOFRON

  • Catalogue Number : BN-O1183

  • Specification : 98%(HPLC)

  • CAS number : 6274-22-2

  • Formula : C8H10N2O

  • Molecular Weight : 150.18

  • PUBCHEM ID : 235516

  • Volume : 5mg

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Catalogue Number

BN-O1183

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

150.18

Appearance

Botanical Source

Structure Type

Category

SMILES

CNC(=O)C1=CC=C(C=C1)N

Synonyms

4-Amino-N-methyl-benzamide/4-Amino-N-methylbenzamide/4-Amino-benzoesaeure-methylamid/Benzamide, 4-amino-N-methyl-/N-methyl-p-aminobenzamide/4-(methylcarbamoyl)aniline/4-Amino-N-methyl-benzamid/4-Aminobenzoylmethylamide/(4-aminophenyl)-N-methylcarboxamide/4-amino-benzoic acid methylamide

IUPAC Name

4-amino-N-methylbenzamide

Density

1.1±0.1 g/cm3

Solubility

Flash Point

174.0±23.2 °C

Boiling Point

364.1±25.0 °C at 760 mmHg

Melting Point

181 °C

InChl

InChl Key

XAGFYNSCWICYPA-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:6274-22-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27260798

Abstract

Whole-genome sequencing data allow detection of copy number variation (CNV) at high resolution. However, estimation based on read coverage along the genome suffers from bias due to GC content and other factors. Here, we develop an algorithm called BIC-seq2 that combines normalization of the data at the nucleotide level and Bayesian information criterion-based segmentation to detect both somatic and germline CNVs accurately. Analysis of simulation data showed that this method outperforms existing methods. We apply this algorithm to low coverage whole-genome sequencing data from peripheral blood of nearly a thousand patients across eleven cancer types in The Cancer Genome Atlas (TCGA) to identify cancer-predisposing CNV regions. We confirm known regions and discover new ones including those covering KMT2C, GOLPH3, ERBB2 and PLAG1. Analysis of colorectal cancer genomes in particular reveals novel recurrent CNVs including deletions at two chromatin-remodeling genes RERE and NPM2. This method will be useful to many researchers interested in profiling CNVs from whole-genome sequencing data.

Title

Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants

Author

Ruibin Xi,corresponding author1 Semin Lee,2 Yuchao Xia,1,3 Tae-Min Kim,4 and Peter J Parkcorresponding author2

Publish date

2016 Jul 27

PMID

31686375

Abstract

Aging population presents a major challenge for many countries in the world and has made the development of efficient means for healthspan extension a priority task for researchers and clinicians worldwide. Anti-aging properties including antioxidant, anti-inflammatory, anti-tumor, and cardioprotective activities have been reported for various phytobioactive compounds (PBCs) including resveratrol, quercetin, curcumin, catechin, etc. However, the therapeutic potential of orally administered PBCs is limited by their poor stability, bioavailability, and solubility in the gastrointestinal tract. Recently, innovative nanotechnology-based approaches have been developed to improve the bioactivity of PBCs and enhance their potential in preventing and/or treating age-associated disorders, primarily those caused by aging-related chronic inflammation. PBC-loaded nanoparticles designed for oral administration provide many benefits over conventional formulations, including enhanced stability and solubility, prolonged half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent advances in this rapidly developing research area.

KEYWORDS

Aging, Age-associated disorder, Phytobioactive compound, Bioavailability, Nanoparticle, Antioxidant, Anti-inflammatory activity

Title

Nanodelivery of phytobioactive compounds for treating aging-associated disorders

Author

Oleh Lushchak,corresponding author1 Olha Strilbytska,1 Alexander Koliada,2 Alina Zayachkivska,1 Nadia Burdyliuk,1 Ihor Yurkevych,1 Kenneth B. Storey,3 and Alexander Vaisermancorresponding author2

Publish date

2020 Feb;

PMID

6784841

Title

Mitral valve prolapse.

Publish date

1981 May 2;


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