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  • Brand : BIOFRON

  • Catalogue Number : BN-O1133

  • Specification : 98%(HPLC)

  • CAS number : 14548-46-0

  • Formula : C12H9NO

  • Molecular Weight : 183.21

  • PUBCHEM ID : 26731

  • Volume : 5mg

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Catalogue Number


Analysis Method





Molecular Weight



Botanical Source

Structure Type





Phenyl 4-Pyridyl Ketone/Phenyl(pyridin-4-yl)methanone




1.139 g/cm3


Flash Point

150 °C

Boiling Point

315 °C

Melting Point

68-72 °C


InChl Key


WGK Germany


HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:14548-46-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




The ruthenium(II) compounds cis-[Ru(bpy)2(4-bzpy)(CO)](PF6)2 (I) and cis-[Ru(bpy)2(4-bzpy)(Cl)](PF6) (II) (4-bzpy=4-benzoylpyridine, bpy=2,2′-bipyridine) were synthesized and characterized by spectroscopic and electrochemical techniques. The crystal structure of II was determined by X-ray diffraction. The photochemical behavior of I in aqueous solution shows that irradiation with ultraviolet light (365nm) releases both CO and 4-bzpy leading to the formation of the cis-[Ru(bpy)2(H2O)2]2+ ion as identified by NMR and electronic spectroscopy. Carbon monoxide release was confirmed with the myoglobin method and by gas chromatographic analysis of the headspace. CO release was not observed when aqueous I was irradiated with blue light (453nm). Changes in the electronic and 1H NMR spectra indicate that I undergoes photoaquation of 4-bzpy to form cis-[Ru(bpy)2(CO)(H2O)]2+. Blue light irradiation of aqueous II released the coordinated 4-bzpy to give the cis-[Ru(bpy)2(H2O)(Cl)]2+ ion. When the latter reaction was carried out in the presence of the nucleobase guanine, Ru-guanine adducts were formed, indicating that the metal containing photoproduct may also participate in biologically relevant reactions. The photochemical behavior of I indicates that it can release either CO or 4-bzpy depending on the wavelength chosen, a feature that may have therapeutic application.


4-benzoylpyridine; Carbon monoxide; Guanine; Metallodrug; Photorelease; Ruthenium.


Photochemical Studies of cis-[Ru(bpy) 2(4-bzpy)(CO)](PF 6) 2 and cis-[Ru(bpy) 2(4-bzpy)(Cl)](PF 6): Blue Light-Induced Nucleobase Binding


Aurideia P de Sousa 1, Edinilton M Carvalho 1, Javier Ellena 2, Eduardo H S Sousa 1, Jackson R de Sousa 1, Luiz G F Lopes 1, Peter C Ford 3, Alda K M Holanda 4

Publish date





Interindividual variability of carbonyl reductase levels in human livers (N = 11) was examined by measuring reductase activity toward various substrates and by western blot analysis using anti-rat ovarian carbonyl reductase CR2 antibody. The carbonyl reductase activity toward p-nitrobenzaldehyde (PNBA) (58.1 +/- 5.4 nmol/mg protein/min, mean +/- SE) was highest among the substrates examined, followed by 4-benzoylpyridine (4BP) (14.4 +/- 2.0 nmol/mg protein/min) and p-nitroacetophenone (PNAP) (2.00 +/- 0.37 nmol/mg protein/min). The reductase activity (6.33 +/- 0.56 pmol/mg protein/min) toward 13,14-dihydro-15-keto-prostaglandin F2 alpha (15KD-PGF2 alpha), which is a diagnostic substrate for rat ovarian carbonyl reductases, was relatively high compared to that in other species. Western blot analysis revealed that each human liver contained several immunoreactive proteins to anti-CR2 antibody. The activities toward 15KD-PGF2 alpha (r = 0.85, P < 0.01) and 4BP (r = 0.84, P < 0.01), but not PNBA (r = 0.53, not significant) or PNAP (r = 0.52, not significant), were closely correlated with the relative amounts of the high molecular weight immunoreactive proteins determined with a densitometer. Thus, the major carbonyl reductases in human liver are similar to those of rat ovarian enzymes.


Interindividual Variability of Carbonyl Reductase Levels in Human Livers


N Iwata 1, N Inazu, S Hara, T Yanase, S Kano, T Endo, F Kuriiwa, Y Sato, T Satoh

Publish date

1993 Apr 22




Context and objective: The present study is to elucidate the comparative inhibition of tetrameric carbonyl reductase (TCBR) activity by alkyl 4-pyridyl ketones, and to characterize its substrate-binding domain.

Materials and methods: The inhibitory effects of alkyl 4-pyridyl ketones on the stereoselective reduction of 4-benzoylpyridine (4-BP) catalyzed by TCBR were examined in the cytosolic fraction of pig heart.

Results: Of alkyl 4-pyridyl ketones, 4-hexanoylpyridine, which has a straight-chain alkyl group of five carbon atoms, inhibited most potently TCBR activity and was a competitive inhibitor. Furthermore, cyclohexyl pentyl ketone, which is substituted by cyclohexyl group instead of phenyl group of hexanophenone, had much lower ability to be reduced than hexanophenone.

Discussion and conclusion: These results suggest that in addition to a hydrophobic cleft corresponding to a straight-chain alkyl group of five carbon atoms, a hydrophobic pocket with affinity for an aromatic group is located in the substrate-binding domain of TCBR.


4-Benzoylpyridine; 4-hexanoylpyridine; competitive inhibition; cyclohexyl pentyl ketone; stereoselective reduction.


Comparative Inhibition of Tetrameric Carbonyl Reductase Activity in Pig Heart Cytosol by Alkyl 4-pyridyl Ketones


Hideaki Shimada 1, Takahiro Tanigawa, Kazunori Matayoshi, Kazufumi Katakura, Ken Babazono, Hiroyuki Takayama, Tsuyoshi Murahashi, Hiroyuki Akita, Toshiyuki Higuchi, Masashi Eto, Yorishige Imamura

Publish date

2014 Jun

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