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4-(Bromomethyl)-7-methoxy coumarin

$64

  • Brand : BIOFRON

  • Catalogue Number : BN-O1852

  • Specification : 98%(HPLC)

  • CAS number : 35231-44-8

  • Formula : C11H9BrO3

  • Molecular Weight : 269.09

  • PUBCHEM ID : 121894

  • Volume : 20mg

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Catalogue Number

BN-O1852

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

269.09

Appearance

Botanical Source

Structure Type

Category

SMILES

COC1=CC2=C(C=C1)C(=CC(=O)O2)CBr

Synonyms

IUPAC Name

4-(bromomethyl)-7-methoxychromen-2-one

Applications

Density

1.6±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

186.8±27.9 °C

Boiling Point

385.3±42.0 °C at 760 mmHg

Melting Point

213-215 °C(lit.)

InChl

InChl Key

CTENSLORRMFPDH-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:35231-44-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

18585211

Abstract

This paper reports a simple, rapid, and effective method for quantitative analysis of 6-methylcoumarin (6-MC) and 7-methoxycoumarin (7-MOC) in cosmetics using excitation-emission matrix (EEM) fluorescence coupled with second-order calibration. After simple pretreatments, the adopted calibration algorithms exploiting the second-order advantage, i.e., parallel factor analysis (PARAFAC) and self-weighted alternating tri-linear decomposition (SWATLD), could allow the individual concentrations of the analytes of interest to be predicted even in the presence of uncalibrated interferences. In the analysis of facial spray, with the external calibration method, the average recoveries attained from PARAFAC and SWATLD with the factor number of 3 (N=3) were 101.4+/-5.5 and 97.5+/-4.1% for 6-MC, and 103.3+/-1.7 and 101.7+/-1.8% for 7-MOC, respectively. Moreover, in the analysis of oil control nourishing toner, the standard addition method (SAM) was suggested to overcome the partial fluorescence quenching of 6-MC induced by the analyte-background interaction, which also yielded satisfactory prediction results. In addition, the accuracy of the two algorithms was also evaluated through elliptical joint confidence region (EJCR) tests as well as figures of merit (FOM), including sensitivity (SEN), selectivity (SEL) and limit of detection (LOD). It was found that both algorithms could give accurate results, only the performance of SWATLD was slightly better than that of PARAFAC in the cases suffering from matrix effects. The method proposed lights a new avenue to determine quantitatively 6-MC and 7-MOC in cosmetics, and may hold great potential to be extended as a promising alternative for more practical applications in cosmetic quality control, due to its advantages of easy sample pretreatment, non-toxic and non-destructive analysis, and accurate spectral resolution and concentration prediction.

Title

Simultaneous determination of 6-methylcoumarin and 7-methoxycoumarin in cosmetics using three-dimensional excitation-emission matrix fluorescence coupled with second-order calibration methods

Author

Jin-Fang Nie 1, Hai-Long Wu, Shao-Hua Zhu, Qing-Juan Han, Hai-Yan Fu, Shu-Fang Li, Ru-Qin Yu

Publish date

2008 Jun 15

PMID

17725866

Abstract

A high-performance liquid chromatography (HPLC) method with fluorescence detection is described for the determination of sodium monofluoroacetate (MFA-Na) in biological samples. 4-Bromomethyl-7-methoxycoumarin is used as a derivatization reagent and reacted with MFA-Na to form 7-methoxy-4-methylenecoumarin monofluoroacetate for HPLC analysis. Chromatographic separation is performed on a Hewlett Packard RP-18 column using methanol-water (60:40, v/v) as the mobile phase. A fluorescent detector is employed with the excitation and emission wavelengths as 319 nm and 390 nm, respectively. The novel method yields a good linear relationship when the concentration of MFA-Na is within 1 and 500 nmol/mL (r = 0.9996). The detection limit is 50 pmol/mL. The established method is applied to determine MFA-Na in biological samples. The recovery rates of MFA-Na are between 81% and 88%, and the relative standard deviations are less than 5%. The method shows good sensitivity and selectivity for the determination of MFA-Na in biological samples.

Title

Determination of sodium monofluoroacetate (1080) in biological samples as its 4-bromomethyl-7-methoxycoumarin derivative by RP-HPLC

Author

Zhenming Xie 1, Wenbing Shi, Lan Liu, Qinying Deng

Publish date

2007 Aug;

PMID

15974068

Abstract

A HPLC-fluorescence method for identification of drying oils from binding media or protective film used in pictorial works of art prior to conservation or restoration is proposed. Fluorescence derivatization of fatty acids released by hydrolysis of structural drying oils is studied. The derivatization reagent was 4-(bromomethyl)-7-methoxycoumarin with 18-crown-6 as catalyst. Mobile phase was programmed from methanol-water (90:10 v/v) to methanol-water (100:0 v/v) in 25 min. The excitation and emission wavelengths were 325 and 395 nm, respectively. Under these chromatographic conditions, coumarin derivatives of myristic, palmitic, oleic and stearic acids were satisfactorily resolved. The method shows good sensitivity, with a detection limit of 6.0 x 10(-8) mmol, and good linearity between 1.0 x 10(-7) and 1.8 x 10(-4) mmol of each analyte. Peak area ratios among fatty acids derivatives, especially the stearic acid/palmitic acid peak area ratio, are useful to identify the drying oils. The proposed method has been successfully applied to artistic samples from items of the cultural heritage of Valencia (Spain).

Title

Identification of lipid binders in old oil paintings by separation of 4-bromomethyl-7-methoxycoumarin derivatives of fatty acids by liquid chromatography with fluorescence detection

Author

J Peris Vicente 1, J V Gimeno Adelantado, M T Domenech Carbo, R Mateo Castro, F Bosch Reig

Publish date

2005 May 27