Colorless crystalline powder
Simple Phenolic Compounds
p-Hydroxybenzaldehyde/4-Hydroxy benzaldehyde/4-Hydroxybenzaldehyde/Bisoprolol Impurity 15
p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
246.6±13.0 °C at 760 mmHg
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:123-08-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
4-Hydroxybenzaldehyde (4-HBA) is a naturally occurring benzaldehyde and the major active constituent of Gastrodia elata. While recent studies have demonstrated metabolic effects of 4-HBA, little is known about the physiological role of 4-HBA in acute wound healing. Here, we investigated the effects and mechanisms of 4-HBA on acute wound healing. Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity. In addition, 4-HBA treatment also promoted wound healing and re-epithelialization in an in vivo excision wound animal model. Combination treatment with 4-HBA and platelet-derived growth factor subunit B homodimer showed synergistic effects in promoting wound healing. Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway. Therefore, 4-HBA could be a candidate therapeutic agent with the potential to promote acute wound healing.
4-Hydroxybenzaldehyde Accelerates Acute Wound Healing Through Activation of Focal Adhesion Signalling in Keratinocytes
Chan Woo Kang 1 2 , Ye Eon Han 1 2 , Jean Kim 1 2 , Joo Heon Oh 2 3 , Yoon Hee Cho 4 , Eun Jig Lee 5
2017 Oct 27
Bacterial metabolism modulated by environmental chemicals could alter antibiotic susceptibility. 4-Hydroxybenzaldehyde (4-HBA), which cannot support the growth of Acinetobacter baumannii, exhibited synergism only with amphenicol antibiotics including chloramphenicol (CAM) and thiamphenicol. Interestingly, this synergistic effect was not observed with other growth-supporting, structurally similar compounds such as 4-hydroxybenzoate. Transcriptomic analysis demonstrated that genes involved in protocatechuate metabolism (pca genes) and osmotic stress (bet genes) were significantly upregulated by 4-HBA and CAM treatment. The 14C-labeled CAM influx was lower in a pcaK1 (encoding a transporter of protocatechuate) deletion mutant and was higher in the pcaK1 overexpressing cells relative to that in the wild type upon 4-HBA treatment. Our kinetic data using 14C-labeled CAM clearly showed that CAM uptake is possibly through facilitated diffusion. Deletion of pcaK1 did not result in the elimination of CAM influx, indicating that CAM does not enter only through PcaK1. The amount of 4-HBA in the culture supernatant was, however, unaffected during the test conditions, validating that it was not metabolized by the bacteria. CAM resistant A. baumannii cells derived by serial passages through CAM-amended media exhibited lower level of pcaK1 gene expression. These results led us to conclude that the activation of PcaK1 transporter is probably linked to cellular CAM susceptibility. This is the first report showing a relationship between CAM influx and aromatic compound metabolism in A. baumannii.
4-Hydroxybenzaldehyde; Acinetobacter; Chloramphenicol; Phenolic compound; Plant extract; Synergism; Synergistic compound.
4-Hydroxybenzaldehyde Sensitizes Acinetobacter Baumannii to Amphenicols
Bora Shin 1 , Chulwoo Park 1 , James A Imlay 2 , Woojun Park 3
The α1β2γ2 subtype of GABAA receptors is the most commonly found GABAA receptor subtype in the mammalian cortex and hippocampus. It is expressed heterologously in the Xenopus laevis oocyte as a α1β2γ2S/L subtype for application as an in vitro model for the screening of compounds that modulate receptor activities. In fact, 4-hydroxybenzaldehyde (4-HB) has been identified as one of the major components in Dendrocalamus asper bamboo shoots in our previous study, and the current study showed that at 101.7 μM, 4-HB significantly reduced the GABA-induced chloride current of GABAA receptors expressed on Xenopus oocytes, indicating a possible GABAergic antagonistic effect at high concentrations.
GABAergic agents; Xenopus oocytes; bamboo shoot; electrophysiology; α1β2γ2 GABAA receptor.
The Effect of 4-hydroxybenzaldehyde on the γ-Aminobutyric Acid Type A Receptor
Jingli Zhang 1 , Habsah Mohamad 2 , Jia Hui Wong 1 , Muhammad Bilal 1 , Abdul Hadi Bin Ismail 2 , Amelia Jane Lloyd 3 1 , Abdul Aziz Mohamed Yusoff 3 1 , Hasnah Osman 4 , Kok Tong Wong 4 , Zamzuri Idris 3 1 5 , Jafri Malin Abdullah 3 1 5