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4-Hydroxyphenethyl alcohol

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-H3015

  • Specification : 98%

  • CAS number : 501-94-0

  • Formula : C8H10O2

  • Molecular Weight : 138.16

  • Volume : 100mg

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Catalogue Number

BF-H3015

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

138.16

Appearance

Botanical Source

Ligustrum lucidum,Rehmannia glutinosa,Apocynum venetum,Acacia catechu,Eleutherococcus senticosus

Structure Type

Phenolics

Category

SMILES

Synonyms

IUPAC Name

Density

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:501-94-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

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Description :

Tyrosol exerts a protective effect against dopaminergic neuronal cell death in in vitro model of Parkinson's disease. PUMID/DOI:23790897 Food Chem. 2013 Nov 15;141(2):1147-57. Experimental evidence suggests that tyrosol [2-(4-Hydroxyphenyl)ethanol] exhibits potent protective activities against several pathogeneses. In this study, we evaluated the protective effect of tyrosol against 1-methyl-4-phenylpyridinium (MPP(+))-induced CATH.a neuron cell death. Tyrosol dose-dependently protected CATH.a cells from MPP(+)-induced cell death and the protection was more apparent after prolong incubation (48h). The data showed that tyrosol treatment suppressed the reduction of phospho-tyrosine hydroxylase level in CATH.a cells. Further, the compound repressed MPP(+)-induced depletion of mitochondrial membrane potential (Δψm) and thereby maintained intracellular ATP production in the cell. The cellular signalling pathway studies revealed that tyrosol protected CATH.a cells from MPP(+)-induced apoptotic signalling, most likely via activation of PI3K/Akt signalling pathway along with up-regulation of anti-oxidative enzymes (SOD-1 and SOD-2) and DJ-1 protein in the cell. Collectively, present study demonstrates that tyrosol significantly protects dopaminergic neurons from MPP(+)-induced degradation, and reveals potential neuroprotective mechanism of tyrosol.