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4-O-Methylhonokiol

$640

  • Brand : BIOFRON

  • Catalogue Number : BN-O1518

  • Specification : 98%(HPLC)

  • CAS number : 68592-15-4

  • Formula : C19H20O2

  • Molecular Weight : 280.4

  • PUBCHEM ID : 155160

  • Volume : 20mg

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Catalogue Number

BN-O1518

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

280.4

Appearance

Botanical Source

Structure Type

Category

SMILES

COC1=C(C=C(C=C1)C2=C(C=CC(=C2)CC=C)O)CC=C

Synonyms

3,5'-diallyl-2'-hydroxy-4-methoxy-1,1'-biphenyl/4'-O-Methylhonokiol/3,5'-diallyl-2'-hydroxy-4-methoxybiphenyl/METHYLHONOKIOL/methoxyhonokiol/4-methoxyhonokiol/4-O-Methyl honokiol

IUPAC Name

2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol

Density

1.054g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

176.2ºC

Boiling Point

396.5ºC at 760 mmHg

Melting Point

InChl

InChl Key

OQFHJKZVOALSPV-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:68592-15-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29068313

Abstract

Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites. We developed a membrane-permeant, photoactivatable PI(4,5)P2, which is loaded into cells in an inactive form and activated by light, allowing sub-second increases in PI(4,5)P2 levels. By combining this compound with electrophysiological measurements in mouse adrenal chromaffin cells, we show that PI(4,5)P2 uncaging potentiates exocytosis and identify synaptotagmin-1 (the Ca2+ sensor for exocytosis) and Munc13-2 (a vesicle priming protein) as the relevant effector proteins. PI(4,5)P2 activation of exocytosis did not depend on the PI(4,5)P2-binding CAPS-proteins, suggesting that PI(4,5)P2 uncaging may bypass CAPS-function. Finally, PI(4,5)P2 uncaging triggered the rapid fusion of a subset of readily-releasable vesicles, revealing a rapid role of PI(4,5)P2 in fusion triggering. Thus, optical uncaging of signaling lipids can uncover their rapid effects on cellular processes and identify lipid effectors.

Research organism: Mouse

Title

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

Author

Alexander M Walter,#1,2,† Rainer Muller,#3,† Bassam Tawfik,#1,† Keimpe DB Wierda,1 Paulo S Pinheiro,1 Andre Nadler,3,4 Anthony W McCarthy,2 Iwona Ziomkiewicz,1,5 Martin Kruse,6 Gregor Reither,3 Jens Rettig,7 Martin Lehmann,2 Volker Haucke,2 Bertil Hille,6 Carsten Schultz,3 and Jakob Balslev Sørensen1

Publish date

2017;

PMID

12324376

Abstract

Fifteen Fusarium species were analyzed by high-performance liquid chromatography for the production of six mycotoxins in corn grits cultures. Production of mycotoxins ranged from 66 to 2,500 μg/kg for fumonisin B1, 0.6 to 1,500 μg/g for moniliformin, 2.2 to 720 μg/g for beauvericin, and 12 to 130 μg/g for fusaproliferin. Fumonisin B2 (360 μg/kg) was produced by two species, fumonisin B3 was not detected in any of the 15 species examined, and Fusarium bulbicola produced none of the six mycotoxins that we analyzed.

Title

Production of Beauvericin, Moniliformin, Fusaproliferin, and Fumonisins B1, B2, and B3 by Fifteen Ex-Type Strains of Fusarium Species†

Author

Joseph Fotso,1 John F. Leslie,2 and J. Scott Smith1,*

Publish date

2002 Oct;

PMID

20663223

Abstract

Background
Intestinal schistosomiasis is often widespread among the populations living around Lake Victoria and on its islands. The Sesse Island group (containing some 84 islands), however, is typically assumed to be a low prevalence zone, with limited transmission, but has never been surveyed in detail. Here, we present a rapid mapping assessment, bringing together snail and parasite information, at 23 sites for the presence of intermediate host snails and at 61 sites for the prevalence of intestinal schistosomiasis in school-aged children (N = 905). Two different diagnostic tools were used and compared at 45 of these sites: Kato-Katz thick faecal smears and circulating cathodic antigen (CCA) urine dipsticks.

Results
Biomphalaria snails were found at 11 sites but in low numbers; none was found shedding schistosome cercariae. At 22 out of the 45 sites, local prevalence by urine and/or stool diagnostics was in excess of 50%, although mean prevalence of intestinal schistosomiasis overall was 34.6% (95% confidence intervals (CI) = 31.0-38.3%) by Kato-Katz and 46.5% (95% CI = 42.7-50.4%) by CCA if ‘trace’ reactions were considered infection-positive (if considered infection-negative, mean prevalence was 28.1% (95% CI = 24.7-31.7%)). Diagnostic congruence between CCA and Kato-Katz was poor and significant discordance in estimated prevalence by location was found, with each often inferring different mass drug administration regimes.

Conclusions
Accurate estimation of schistosome prevalence is important for determining present and future treatment needs with praziquantel; the wide range of schistosome prevalence across the Sesse Island group requires a treatment regime largely tailored to each island. In high prevalence locations, further malacological sampling is required to confirm the extent of local transmission, especially on the northern islands within the group. The observation that different diagnostic tests can provide varying results in terms of estimating prevalence by location, and hence change treatment recommendations, suggests that care must be taken in interpreting raw prevalence data. In particular, further research into the reasons for the differences in the poorer performance of the CCA test should be pursued.

Title

Epidemiology and control of intestinal schistosomiasis on the Sesse Islands, Uganda: integrating malacology and parasitology to tailor local treatment recommendations

Author

Claire J Standley,1,2 Moses Adriko,3 Moses Arinaitwe,3 Aaron Atuhaire,3 Francis Kazibwe,3 Alan Fenwick,4 Narcis B Kabatereine,3 and J Russell Stothardcorresponding author2

Publish date

2010;


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