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4′-Prenyloxyresveratrol

$655

Brand : BIOFRON
Catalogue Number : AV-C90824
Specification : 98%
CAS number : 69065-16-3
Formula : C19H20O4
Molecular Weight : 312.4
PUBCHEM ID : 5281724
Volume : 10mg

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Catalogue Number

AV-C90824

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

312.4

Appearance

Powder

Botanical Source

Structure Type

Phenols

Category

Standards;Natural Pytochemical;API

SMILES

CC(=CCC1=C(C=C(C=C1O)C=CC2=C(C=C(C=C2)O)O)O)C

Synonyms

4'-Prenyloxyresveratrol

IUPAC Name

5-[(E)-2-(2,4-dihydroxyphenyl)ethenyl]-2-(3-methylbut-2-enyl)benzene-1,3-diol

Density

1.29g/cm3

Solubility

Helicobacter pylori, Microbial drug resistance, Clarithromycin, Fluoroquinolones, Molecular diagnostic techniques

Flash Point

264.1ºC

Boiling Point

560.5ºC at 760 mmHg

Melting Point

197-199℃

InChl

InChl Key

FEHGVKWVMWWVQZ-SNAWJCMRSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:69065-16-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

27672279

Abstract

AIM
To evaluate bacterial resistance to clarithromycin and fluoroquinolones in Brazil using molecular methods.

METHODS
The primary antibiotic resistance rates of Helicobacter pylori (H. pylori) were determined from November 2012 to March 2015 in the Southern, South-Eastern, Northern, North-Eastern, and Central-Western regions of Brazil. Four hundred ninety H. pylori patients [66% female, mean age 43 years (range: 18-79)] who had never been previously treated for this infection were enrolled. All patients underwent gastroscopy with antrum and corpus biopsies and molecular testing using GenoType HelicoDR (Hain Life Science, Germany). This test was performed to detect the presence of H. pylori and to identify point mutations in the genes responsible for clarithromycin and fluoroquinolone resistance. The molecular procedure was divided into three steps: DNA extraction from the biopsies, multiplex amplification, and reverse hybridization.

RESULTS
Clarithromycin resistance was found in 83 (16.9%) patients, and fluoroquinolone resistance was found in 66 (13.5%) patients. There was no statistical difference in resistance to either clarithromycin or fluoroquinolones (P = 0.55 and P = 0.06, respectively) among the different regions of Brazil. Dual resistance to clarithromycin and fluoroquinolones was found in 4.3% (21/490) of patients. The A2147G mutation was present in 90.4% (75/83), A2146G in 16.9% (14/83) and A2146C in 3.6% (3/83) of clarithromycin-resistant patients. In 10.8% (9/83) of clarithromycin-resistant samples, more than 01 mutation in the 23S rRNA gene was noticed. In fluoroquinolone-resistant samples, 37.9% (25/66) showed mutations not specified by the GenoType HelicoDR test. D91N mutation was observed in 34.8% (23/66), D91G in 18.1% (12/66), N87K in 16.6% (11/66) and D91Y in 13.6% (9/66) of cases. Among fluoroquinolone-resistant samples, 37.9% (25/66) showed mutations not specified by the GenoType HelicoDR test.

CONCLUSION
The H. pylori clarithromycin resistance rate in Brazil is at the borderline (15%-20%) for applying the standard triple therapy. The fluoroquinolone resistance rate (13.5%) is equally concerning.

KEYWORDS

Helicobacter pylori, Microbial drug resistance, Clarithromycin, Fluoroquinolones, Molecular diagnostic techniques

Title

Detection of Helicobacter pylori resistance to clarithromycin and fluoroquinolones in Brazil: A national survey

Author

Bruno Squarcio Sanches, Gustavo Miranda Martins, Karine Lima, Bianca Cota, Luciana Dias Moretzsohn, Laercio Tenorio Ribeiro, Helenice P Breyer, Ismael Maguilnik, Aline Bessa Maia, Joffre Rezende-Filho, Ana Carolina Meira, Henrique Pinto, Edson Alves, Ramiro Mascarenhas, Raissa Passos, Julia Duarte de Souza, Osmar Reni Trindade, Luiz Gonzaga Coelho

Publish date

2016 Sep 7;

PMID

30013995

Abstract

Introduction:
Medical schools face increasing challenges to accommodate new health care needs. However, little has changed regarding the students’ education. In addition, educators face the challenge of improving their teaching approach, making it suitable and effective for the new generation. The purpose of this work was to describe and contextualize the application of active pedagogical methodologies using the virtual learning environment (VLE) as a tool to improve the students’ performance.

Methods:
This research is a quantitative and qualitative case study, carried out in one faculty of medicine in the state of Amazonas. Given a total population of senior students in this faculty, the number of participants corresponds to a proportion of 75% in the period of two years. This work required a paradigm shift, by focusing on interactive and technological teaching, professionalism, mentoring, communication, and feedback. Courses using virtual learning environment (VLE) should be prone to interaction, dialogue, collaboration and, asynchronously, autonomy. One of the key aspects of VLE content production is to select appropriate subject matters and texts to be discussed. It is through the VLE contents that the mediation of knowledge construction process and the participants’ interaction takes place.

Results:
The improvement over the pre-test evaluation was evident, ranging between 12.59 and 50.9%, depending on the subject matter, to 81.31% in the final evaluation. In addition, the students expressed consistently positive opinions regarding the use of VLE.

Conclusion:
The use of VLE as a pedagogical tool, in an interactive format and appropriate to the transmission of information and knowledge construction, was adequate for an evident improvement in the cognitive performance of the senior students of medicine. In addition, the positive evaluation of the students regarding the pedagogical methodology used constitutes an added value of this approach.

KEYWORDS

Teaching , Education , Medical , User-computer interface

Title

Pedagogical mediation using the virtual learning environment and the new generation: A search for improved performance in medical education

Author

JOSE SEBASTIAO AFONSO, PEDRO SOUSA MARTINS, GERALDO FELIPE BARBOSA, LUIZ FERREIRA, MANOEL JOAO BATISTA CASTELLO GIRAO

Publish date

2018 Jul;

PMID

29593895

Abstract

Background
Fascioliasis is an important parasitic disease. In the northern region of Brazil, a human parasite infection has been reported through a coprological survey. Eggs of Fasciola hepatica were found in fecal samples of 11 individuals. Knowledge of the infection in animals or the presence of snails is necessary to address the possibility of the parasite cycle occurrence in that region. The aim of this study was to describe the transmission of human fascioliasis in Canutama, Amazonas, in Western Amazonia, Brazil.

Methods
Serological (ELISA and Western Blot, WB) and parasitological analyses were carried out in humans. In addition, the presence of the intermediate snail host within the community was examined.

Results
A total of 434 human samples were included in the study, of which 36 (8.3%) were reactive by ELISA and 8 (1.8%) were reactive by WB. Fasciola hepatica eggs were found in one human sample. The occurrence of the intermediated host was recorded and 31/43 specimens were identified as Lymnaea columella. Conclusion. Canutama constitutes a focus of transmission of human fascioliasis. This study describes the first serological survey for human fascioliasis, as well as its simultaneous occurrence in human hosts and possible intermediates performed in northern Brazil.

Title

Cross-Sectional Serological Survey of Human Fascioliasis in Canutama Municipality in Western Amazon, Brazil

Author

Marcel Goncalves Maciel, Walter dos Santos Lima, Francisco Lazaro Moreira de Almeida, Leila In?s Aguiar Raposo Camara Coelho, Guilherme Alfredo Novelino Ara?jo, Mariana Gomes Lima, Luiz Henrique Goncalves Maciel, Cintia Aparecida de Jesus Pereira, Thais Costa da Silva Maciel, Jorge Augusto de Oliveira Guerra, Rosa Amelia Goncalves Santana, Maria das Gracas Vale Barbosa Guerra

Publish date

2018;