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4,4′-Bis(5-methyl-2-benzoxazolyl)stilbene

$125

  • Brand : BIOFRON

  • Catalogue Number : BN-O1094

  • Specification : 98%(HPLC)

  • CAS number : 2397-00-4

  • Formula : C30H22N2O2

  • Molecular Weight : 442.5

  • PUBCHEM ID : 6436901

  • Volume : 5mg

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Catalogue Number

BN-O1094

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

442.5

Appearance

Botanical Source

Structure Type

Category

SMILES

CC1=CC2=C(C=C1)OC(=N2)C3=CC=C(C=C3)C=CC4=CC=C(C=C4)C5=NC6=C(O5)C=CC(=C6)C

Synonyms

2,2'-(1,2-Ethenediyldi-4,1-phenylene)bis(5-methyl-1,3-benzoxazole)/bismethylbenzoxazolylstilbene/Benzoxazole, 2,2'-(1,2-ethenediyldi-4,1-phenylene)bis[5-methyl-/Optical Brightener OB-2/Fluorescent Brightener Agent OB-2/4,4'-Bis(5-Methyl-2-benzoxazolyl)stilbene/1,2-Bis(4-(5-methylbenzo[d]oxazol-2-yl)phenyl)ethene/2,2'-(Ethene-1,2-diyldi-4,1-phenylene)bis(5-methyl-1,3-benzoxazole)

IUPAC Name

5-methyl-2-[4-[(E)-2-[4-(5-methyl-1,3-benzoxazol-2-yl)phenyl]ethenyl]phenyl]-1,3-benzoxazole

Density

1.2±0.1 g/cm3

Solubility

Flash Point

296.7±21.0 °C

Boiling Point

590.9±39.0 °C at 760 mmHg

Melting Point

336-342°C

InChl

InChl Key

OKEZAUMKBWTTCR-AATRIKPKSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:2397-00-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30988142

Abstract

VL-2397, a novel, systemic antifungal agent, has potent in vitro and in vivo fungicidal activity against Aspergillus species. Plasma concentrations from a phase 1 study were used to construct a population pharmacokinetic (PPK) model for VL-2397. Healthy subjects aged 18 to 55 years received single doses of VL-2397, ranging from 3 to 1,200 mg, multiple daily doses of 300, 600, or 1,200 mg for 7 days, or 300 mg three times/day for 7 days followed by 600 mg daily for 21 days. Plasma samples were collected throughout the dosing intervals. Sixty-six subjects provided 1,908 concentrations. Drug concentrations over time were increased less than dose proportionally for doses above 30 mg. Dose-normalized concentrations plotted over time did not overlap. A 3-compartment nonlinear saturable binding model fit the data well. Clearance increased with dose, and mean values ranged from 0.4 liters/h at 3 mg to 8.5 liters/h at 1,200 mg. Mean volume in the central compartment ranged from 4.8 to 6.9 liters across doses. In the first 24 h, once-daily dosing results in a rapid decrease in concentrations by hour 16 to approximately 1 mg/liter, regardless of dose, with slow clearance over time. Administration of 300 mg every 8 h achieved concentrations above 1 mg/liter over an entire 24-h period. There was a significant relationship between body surface area and clearance. The data suggest that VL-2397 has nonlinear saturable binding kinetics. Protein binding is the likely primary source of the nonlinearity. The PPK model can now be used to optimize dosing by bridging the kinetics to efficacious pharmacodynamic targets.

KEYWORDS

VL-2397, aspergillosis, nonlinear kinetics, population pharmacokinetics, saturable binding kinetics

Title

Population Pharmacokinetic Modeling of VL-2397, a Novel Systemic Antifungal Agent: Analysis of a Single- and Multiple-Ascending-Dose Study in Healthy Subjects

Author

Laura L. Kovanda,corresponding authora Sean M. Sullivan,c Larry R. Smith,c Amit V. Desai,a Pete L. Bonate,a and William W. Hopeb

Publish date

2019 Jun;

PMID

25925799

Abstract

MicroRNA have been recently discovered in human milk signifying potentially important functions for both the lactating breast and the infant. Whilst human milk microRNA have started to be explored, little data exist on the evaluation of sample processing, and analysis to ensure that a full spectrum of microRNA can be obtained. Human milk comprises three main fractions: cells, skim milk, and lipids. Typically, the skim milk fraction has been measured in isolation despite evidence that the lipid fraction may contain more microRNA. This study aimed to standardize isolation of microRNA and total RNA from all three fractions of human milk to determine the most appropriate sampling and analysis procedure for future studies. Three different methods from eight commercially available kits were tested for their efficacy in extracting total RNA and microRNA from the lipid, skim, and cell fractions of human milk. Each fraction yielded different concentrations of RNA and microRNA, with the highest quantities found in the cell and lipid fractions, and the lowest in skim milk. The column‐based phenol‐free method was the most efficient extraction method for all three milk fractions. Two microRNAs were expressed and validated in the three milk fractions by qPCR using the three recommended extraction kits for each fraction. High expression levels were identified in the skim and lipid milk factions for these microRNAs. These results suggest that careful consideration of both the human milk sample preparation and extraction protocols should be made prior to embarking upon research in this area. J. Cell. Biochem. 116: 2397-2407, 2015. © 2015 The Authors. Journal of Cellular Biochemistry Published by Wiley Periodicals, Inc.

KEYWORDS

BREASTMILK, HUMAN MILK, RNA, microRNA, CELLS, LIPIDS, FAT, FAT GLOBULE, SKIM MILK, MILK FRACTIONS

Title

Human Milk MicroRNA and Total RNA Differ Depending on Milk Fractionation

Author

Mohammed Alsaweed, 1 , 2 Anna R. Hepworth, 1 Christophe Lefevre, 3 Peter E. Hartmann, 1 Donna T. Geddes, 1 and Foteini Hassiotoucorresponding author 1

Publish date

2015 Oct;

PMID

29137151

Abstract

In this study, the complete mitochondrial genome of Cryptocercus meridianus was sequenced. The circular mitochondrial genome is 15,322 bp in size and contains 13 protein-coding genes, two ribosomal RNA genes (12S rRNA and 16S rRNA), 22 transfer RNA genes, and one D-loop region. We compare the mitogenome of C. meridianus with that of C. relictus and C. kyebangensis. The base composition of the whole genome was 45.20%, 9.74%, 16.06%, and 29.00% for A, G, C, and T, respectively; it shows a high AT content (74.2%), similar to the mitogenomes of C. relictus and C. kyebangensis. The protein-coding genes are initiated with typical mitochondrial start codons except for cox1 with TTG. The gene order of the C. meridianus mitogenome differs from the typical insect pattern for the translocation of tRNA-SerAGN, while the mitogenomes of the other two Cryptocercus species, C. relictus and C. kyebangensis, are consistent with the typical insect pattern. There are two very long non-coding intergenic regions lying on both sides of the rearranged gene tRNA-SerAGN. The phylogenetic relationships were constructed based on the nucleotide sequence of 13 protein-coding genes and two ribosomal RNA genes. The mitogenome of C. meridianus is the first representative of the order Blattodea that demonstrates rearrangement, and it will contribute to the further study of the phylogeny and evolution of the genus Cryptocercus and related taxa.

KEYWORDS

Cryptocercus meridianus, Blattodea, mitogenome, gene, rearrangement, phylogenetic analysis

Title

The Complete Mitogenome of the Wood-Feeding Cockroach Cryptocercus meridianus (Blattodea: Cryptocercidae) and Its Phylogenetic Relationship among Cockroach Families

Author

Weijun Li, Zongqing Wang, and Yanli Che*

Publish date

2017 Nov;


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