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4,9,9′-Trihydroxy-3,3′-dimethoxy-8,4′-oxyneolignan

$1,024

  • Brand : BIOFRON

  • Catalogue Number : BN-B0111

  • Specification : 98%(HPLC)

  • CAS number : 53505-68-3

  • Formula : C20H26O6

  • Molecular Weight : 362.42

  • PUBCHEM ID : 76373116

  • Volume : 5mg

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Catalogue Number

BN-B0111

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

362.42

Appearance

Powder

Botanical Source

Structure Type

Phenylpropanoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C=CC(=C1)CCCO)OC(CC2=CC(=C(C=C2)O)OC)CO

Synonyms

Benzenepropanol, 4-hydroxy-β-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-3-methoxy-/1-(4-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-hydroxypropyl)phenoxy]propan-3-ol/4-{3-Hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]propyl}-2-methoxyphenol/3-(4-hydroxy-3-methoxy-phenyl)-2-[4-(3-hydroxy-propyl)-2-methoxy-phenoxy]-propan-1-ol/4,9,9'-Trihydroxy-3,3'- dimethoxy-8,4'-oxyneolignan

IUPAC Name

4-[3-hydroxy-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]propyl]-2-methoxyphenol

Applications

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

308.7±30.1 °C

Boiling Point

586.7±50.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

UAGBDLXEDIGWJU-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:53505-68-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

20433033

Title

Trends in Tuberculosis Mortality in the United States, 1990-2006: A Population-Based Case-Control Study

Author

Richard S. Jung, MPH,a,b Jonathan R. Bennion, MPH,c Frank Sorvillo, PhD,d and Amy Bellomy, PhD, MPH, RNe

Publish date

2010 May-Jun;

PMID

31061169

Abstract

Bacteria form complex multicellular structures on solid surfaces known as biofilms, which allow them to survive in harsh environments. A hallmark characteristic of mature biofilms is the high-level antibiotic tolerance (up to 1,000 times) compared with that of planktonic cells. Here, we report our new findings that biofilm cells are not always more tolerant to antibiotics than planktonic cells in the same culture. Specifically, Escherichia coli RP437 exhibited a dynamic change in antibiotic susceptibility during its early-stage biofilm formation. This phenomenon was not strain specific. Upon initial attachment, surface-associated cells became more sensitive to antibiotics than planktonic cells. By controlling the cell adhesion and cluster size using patterned E. coli biofilms, cells involved in the interaction between cell clusters during microcolony formation were found to be more susceptible to ampicillin than cells within clusters, suggesting a role of cell-cell interactions in biofilm-associated antibiotic tolerance. After this stage, biofilm cells became less susceptible to ampicillin and ofloxacin than planktonic cells. However, when the cells were detached by sonication, both antibiotics were more effective in killing the detached biofilm cells than the planktonic cells. Collectively, these results indicate that biofilm formation involves active cellular activities in adaption to the attached life form and interactions between cell clusters to build the complex structure of a biofilm, which can render these cells more susceptible to antibiotics. These findings shed new light on bacterial antibiotic susceptibility during biofilm formation and can guide the design of better antifouling surfaces, e.g., those with micron-scale topographic structures to interrupt cell-cell interactions.

IMPORTANCE Mature biofilms are known for their high-level tolerance to antibiotics; however, antibiotic susceptibility of sessile cells during early-stage biofilm formation is not well understood. In this study, we aim to fill this knowledge gap by following bacterial antibiotic susceptibility during early-stage biofilm formation. We found that the attached cells have a dynamic change in antibiotic susceptibility, and during certain phases, they can be more sensitive to antibiotics than planktonic counterparts in the same culture. Using surface chemistry-controlled patterned biofilm formation, cell-surface and cell-cell interactions were found to affect the antibiotic susceptibility of attached cells. Collectively, these findings provide new insights into biofilm physiology and reveal how adaptation to the attached life form may influence antibiotic susceptibility of bacterial cells.

KEYWORDS

antibiotic tolerance, biofilm, cell-cell interaction, cell-surface interaction, patterned biofilm

Title

Antibiotic Susceptibility of Escherichia coli Cells during Early-Stage Biofilm Formation

Author

Huan Gu,a,b Sang Won Lee,a,b Joseph Carnicelli,a,b Zhaowei Jiang,a,b and Dacheng Rencorresponding authora,b,c,d

Publish date

2019 Sep 15;

PMID

30873017

Abstract

Locomotor stability is challenged by internal perturbations, e.g., motor noise, and external perturbations, e.g., changes in surface compliance. One means to compensate for such perturbations is to employ motor synergies, defined here as co-variation among a set of elements that acts to stabilize, or provide similar trial-to-trial (or step-to-step) output, even in the presence of small variations in initial conditions. Whereas evidence exists that synergies related to the upper extremities can be trained, the extent to which lower limb synergies, such as those which may be needed to successfully locomote in complex environments, remains unknown. The purpose of this study was to evaluate if resistance training (RT) in unstable environments could promote coordination patterns associated with stronger synergies during gait. Sixty-eight participants between the age of 65 and 80 were randomly assigned to one of three different RT modalities: stable whole-limb machine-based RT (S-MRT), instability free-weight RT (I-FRT), and stable machine-based adductor/abductor RT (S-MRTHIP). Before and after RT, participants walked across an even lab floor and a more challenging uneven surface with and without holding a weighted bag. The uncontrolled manifold control analysis (UCM) was used to calculate the synergy index (i.e., strength of the kinematic synergy) related to stabilization of our performance variable, the mediolateral trajectory of the swing foot, under each condition. Regardless of RT group, there was no effect of RT on the synergy index when walking across the even lab floor. However, the synergy index during the two uneven surface conditions was stronger after I-FRT but was not affected by the other RT modalities. The stronger synergy index for the I-FRT group was due to improved coordination as quantified by an overall increase in variability in elemental variable space but a decrease in the variability that negatively affects performance. The unstable environment offered by I-FRT allows for exploration of motor solutions in a manner that appears to transfer to challenging locomotor tasks. Introducing tasks that promote, rather than limit, exploration of motor solutions seems to be a valuable exercise modality to strengthen kinematic synergies that cannot be achieved with traditional strengthening paradigms (e.g., S-MRT).

Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03017365.

KEYWORDS

irregular surface, unstable resistance training, uncontrolled manifold, motor redundancy, elderly, gait, perturbation

Title

Instability Resistance Training Decreases Motor Noise During Challenging Walking Tasks in Older Adults: A 10-Week Double-Blinded RCT

Author

Nils Eckardt1,2,* and Noah J. Rosenblatt3

Publish date

2019;