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4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-3-[(4-methoxyphenyl)methyl]-, (R)-

$717

  • Brand : BIOFRON

  • Catalogue Number : BD-P0462

  • Specification : 98.0%(HPLC)

  • CAS number : 118204-64-1

  • Formula : C17H16O6

  • Molecular Weight : 316.305

  • PUBCHEM ID : 138857789

  • Volume : 10mg

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Catalogue Number

BD-P0462

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

316.305

Appearance

Powder

Botanical Source

Structure Type

Other Flavonoids

Category

SMILES

COC1=CC=C(C=C1)CC2(COC3=CC(=CC(=C3C2=O)O)O)O

Synonyms

(3R)-3,5,7-trihydroxy-3-[(4-methoxyphenyl)methyl]-2H-chromen-4-one

IUPAC Name

(3R)-3,5,7-trihydroxy-3-[(4-methoxyphenyl)methyl]-2H-chromen-4-one

Applications

Density

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

Boiling Point

Melting Point

InChl

InChI=1S/C17H16O6/c1-22-12-4-2-10(3-5-12)8-17(21)9-23-14-7-11(18)6-13(19)15(14)16(17)20/h2-7,18-19,21H,8-9H2,1H3/t17-/m1/s1

InChl Key

BLSFQQNRFOVLGQ-QGZVFWFLSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:118204-64-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

17184537

Abstract

Main results

Title

The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chicken

Author

Kazuyoshi Hosomichi,1 Takashi Shiina,1 Shingo Suzuki,2 Masayuki Tanaka,2 Sayoko Shimizu,1 Shigehisa Iwamoto,2 Hiromi Hara,2 Yutaka Yoshida,2 Jerzy K Kulski,1,3 Hidetoshi Inoko,corresponding author#1 and Kei Hanzawacorresponding author#2

Publish date

2006;

PMID

20339535

Abstract

Background
Influenza A viruses are major human and animal pathogens with huge economic and societal impact from illness, hospitalizations, and deaths. Virus-like particles (VLPs) of influenza virus have been suggested as a vaccine candidate offering improved safety and efficacy. To develop this concept further, we established a flexible platform to efficiently generate different subtypes of mammalian-expressed influenza VLPs. Here we demonstrate that these mammalian VLPs strongly resemble the authentic viruses in structure, particle size and composition of host factors, and even glycosylation of viral antigens.

Methodology/Principal Findings
In this study, a mammalian VLP system was established by stable co-expression of four influenza structural proteins (HA, NA, M1, and M2) in a Vero cell line. By replacing the surface glycoproteins of HA and NA, we converted the H3N2-VLP subtype to H5N1-VLP. After centrifugation purification of conditioned media, the particle morphologies, average sizes, and hemagglutination abilities of secreted VLPs were characterized, and the VLP constituents were identified by LC/MS/MS. Protease protection assays demonstrated that specific cellular proteins that co-purified with influenza virions were integrated into mammalian VLPs. The glycosylation profiles of mammalian VLPs as revealed by deglycosylation assays were similar to that of progeny viruses produced from Vero cells. Vaccination of mice with 2.5 µg and above of H5N1-VLP elicited H5-specific IgG1 antibodies and resulted in full protection against lethal infection with homologous virus. These results provide compelling evidence that mammalian VLPs closely emulate the exterior of authentic virus particles not only in antigen presentation but also in biological properties and should provide promising vaccine candidates.

Conclusions/Significance
This flexible mammalian influenza VLP system offers a superior alternative to the conventional reverse genetic vaccine platform without concerns over inadequate presentation of immune antigens or limitations imposed by the manipulation of real viruses.

Title

Mammalian Expression of Virus-Like Particles for Advanced Mimicry of Authentic Influenza Virus

Author

Chia-Ying Wu, 1 Yi-Chun Yeh, 1 Yu-Chih Yang, 1 Ching Chou, 1 Ming-Tsan Liu, 2 Ho-Sheng Wu, 2 Jia-Tsrong Chan, 3 and Pei-Wen Hsiao 1 , * Charlotte Hauser, Editor

Publish date

2010;

Title

Basic data

Publish date

1981 May