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5α-Hydroxycostic acid

$560

  • Brand : BIOFRON

  • Catalogue Number : BD-P0706

  • Specification : 95.0%(HPLC)

  • CAS number : 132185-83-2

  • Formula : C15H22O3

  • Molecular Weight : 250.33

  • PUBCHEM ID : 14705651

  • Volume : 5mg

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Catalogue Number

BD-P0706

Analysis Method

HPLC,NMR,MS

Specification

95.0%(HPLC)

Storage

-20℃

Molecular Weight

250.33

Appearance

Powder

Botanical Source

Structure Type

Sesquiterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC12CCCC(=C)C1(CC(CC2)C(=C)C(=O)O)O

Synonyms

2-[(2R,4aR,8aR)-8a-Hydroxy-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid/2-Naphthaleneacetic acid, decahydro-8a-hydroxy-4a-methyl-α,8-bis(methylene)-, (2R,4aR,8aR)-

IUPAC Name

2-[(2R,4aR,8aR)-8a-hydroxy-4a-methyl-8-methylidene-2,3,4,5,6,7-hexahydro-1H-naphthalen-2-yl]prop-2-enoic acid

Applications

Density

1.1±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

213.8±23.3 °C

Boiling Point

406.4±38.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C35H52O9/c1-17(12-18(36)28-31(4,5)44-28)25-19(37)13-32(6)22-9-8-21-30(2,3)24(43-29-27(41)26(40)20(38)15-42-29)10-11-34(21)16-35(22,34)23(39)14-33(25,32)7/h9,17,20-21,23-29,38-41H,8,10-16H2,1-7H3/t17-,20-,21+,23+,24+,25+,26+,27-,28+,29+,32+,33-,34-,35+/m1/s1

InChl Key

UEQIFFFWXPAQCB-BPLDGKMQSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:132185-83-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

30356052

Abstract

Background
Higher body mass index (BMI) and low physical activity have been associated with increased prevalence of fecal incontinence (FI) in cross-sectional studies, but prospective studies examining the role of these factors are lacking. We sought to determine whether BMI and/or physical activity are associated with risk of FI among older women.

Methods
We prospectively examined the association between BMI and physical activity and risk of FI in the Nurses’ Health Study among 51,708 women who were free of FI in 2008. We defined FI as at ≥1 liquid or solid FI episode/month during the past year reported in 2010 or 2012. We used Cox proportional hazards models to calculate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for FI according to physical activity and BMI, adjusting for potential confounding factors.

Results
During more than 175,000 person-years of follow-up, we documented 5954 cases of incident FI. Compared with women in the lowest activity category (<3 metabolic equivalent of task (MET)-hrs/week), multivariable-adjusted HRs for FI were 0.86 (95% CI 0.80-0.93) for women doing 3-8 MET-hrs/week, 0.78 (95% CI 0.72-0.84) for 9-17 MET-hrs/week, 0.76 (95% CI 0.69-0.83) for 18-26 MET-hrs/week, and 0.75 (95% CI 0.70-0.81) for 27 + MET-hrs/week (Ptrend = <0.0001). There was no association between BMI and risk of FI. Conclusions Higher levels of physical activity were associated with a modest reduction (25%) in risk of incident FI among older women. These results support a potential role of ongoing physical activity in the neuromuscular health of the anorectal continence mechanism with aging. Translational impact These results support a potential role of ongoing physical activity in the neuromuscular health of the anorectal continence mechanism with aging.

Title

Physical Activity, BMI, and Risk of Fecal Incontinence in the Nurses’ Health Study

Author

Kyle Staller, MD, MPH,corresponding author1,2,3 Mingyang Song, MD, ScD,2 Francine Grodstein, ScD,4 Catherine A. Matthews, MD,5 William E. Whitehead, PhD,6 Braden Kuo, MD, MSc,1,3 Andrew T. Chan, MD, MSc,1,2,4 and Mary K. Townsend, ScD4

Publish date

2018 Oct;